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| 1 | Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis显示文摘BACKGROUND For palliation of malignant biliary obstruction(MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography(ERCP)with the placement of metallic stents. Endoscopic ultrasound(EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure.Recently, however, there have been robust randomized clinical trials(RCTs)comparing EUS-guided drainage and ERCP as primary approaches to MBO.AIM To compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO.METHODS This was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment,Development and Evaluation criteria.RESULTS The database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients(112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96%n and 91.81%, respectively, with a risk difference(RD) of 0.00%(95%CI:-0.07, 0.07;P = 0.97; I^2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of-0.01%(95%CI:-0.12, 0.10; P = 0.90; I^2 =0%). The mean difference(MD) for the duration of the procedure was-0.12%(95%CI:-8.20, 7.97; P = 0.98; I^2 = 84%). In the EUS and ERCP groups, there were14 and 25 adverse events, respectively, with an RD of-0.06%(95%CI:-0.23, 0.12; P= 0.54; I^2 = 77%). The MD for stent patency was 9.32%(95%CI:-4.53, 23.18; P =0.19; I^2 = 44%). The stent dysfunction rate was significantly lower in the EUS t group(MD =-0.22%; 95 CI:-0.35,-0.08; P = 0.001; I^2 = 0%).CONCLUSION EUS represents an interesting alternative to ERCP for MBO drainage,demonstrating lower stent dysfunction rates compared with ERCP. Technical and clinical success, duration, adverse events and patency rates were similar. | Fernanda P Logiudice Wanderlei M Bernardo Facundo Galetti Vitor M Sagae Carolina O Matsubayashi Antonio C Madruga Neto Vitor O Brunaldi Diogo T H de Moura Tomazo Franzini Spencer Cheng Sergio E Matuguma Eduardo G H de Moura | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，4： | 6 |
| 2 | Mutation analysis of the RPGR gene reveals novel mutations in south European patients with X-linked retinitis pigmentosa显示文摘 | Miano MG Testa F Strazzullo M Trujillo M De Bernardo C Grammatico B | | 0，，： | 2 |
| 3 | Clinical significance of'anti-HBc alone'in human immunodeficiency virus-positive patients显示文摘AIM:To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection('anti-HBc alone')among human immunodeficiency virus(HIV) type-1 infected patients.Occult hepatitis B infection frequency was also evaluated. METHODS:Three hundred and forty eight histories from 2388 HIV-positive patients were randomly reviewed.Patients with serological markers of hepatitis B virus(HBV)infection were classified into three groups:past hepatitis,'anti-HBc alone'and chronic hepatitis.Determination of DNA from HBV,and RNA and genotype from hepatitis C virus(HCV)were performed on'anti-HBc alone'patients. RESULTS:One hundred and eighty seven(53.7%) HIV-positive patients had markers of HBV infection: 118 past infection(63.1%),14 chronic hepatitis (7.5%)and 55'anti-HBc alone'(29.4%).Younger age[2.3-fold higher per every 10 years younger;95% confidence intervals(CI)1.33-4.00]and antibodies to HCV infection[odds ratio(OR)2.87;95%CI 1.10-7.48]were factors independently associated with the'anti-HBc alone'pattern.No differences in liver disease frequency were detected between both groups. Serum levels of anti-HBs were not associated with HCV infection(nor viral replication or HCV genotype),or with HIV replication or CD4 level.No'anti-HBc alone' patient tested positive for HBV DNA. CONCLUSION:'Anti-HBc alone'prevalence in HIVpositive patients was similar to previously reported data and was associated with a younger age and with antibodies to HCV infection.In clinical practice,HBV DNA determination should be performed only in those patients with clinical or analytical signs of liver injury. | M~aTeresa Pérez-Rodríguez Bernardo Sopea Manuel Crespo Alberto Rivera Teresa González del Blanco Antonio Ocampo César Martínez-Vázquez | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 4 | A comparative analysis of alternative models to predict the tensile strength of untreated and surface oxidized carbon fibers显示文摘 | PAIVA M C BERNARDO C A EDIE D D | 2001 | Carbon2001，39，7： | 1 |
| 5 | Completeness guarantees for incomplete Ontology reasoners: theory and practice显示文摘 | Bernardo C Grau Boris Motik Giorgos Stoilos | 2012 | Journal of Artificial Intelligence Research2012，43，： | 1 |
| 6 | 显示文摘 | Tibbetts G G Bernardo C A Gorkiewicz D W | 1994 | Carbon1994，32，4： | 1 |
| 7 | Breastfeeding and school achievement in Brazilian adolescents显示文摘 | Cesar G Fernando C Bernardo L | 2005 | Acta Paediatr2005，94，： | 1 |
| 8 | Effectsof inflammatory cytokines on the release and cleavage ofthe endothelial cell-derived ultralarge vonWillebrand factormuhimers under flow显示文摘 | BERNARDO A BALL C NOLASCO L | | 0，，01： | 1 |
| 9 | Mechanical,surface and interfacial characterization of pitch and PAN-based carbon fibers显示文摘 | Paiva M C bernardo C A Nardin M | 2000 | Carbon2000，38，9： | 1 |
| 10 | lnsulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment显示文摘 | Angiolillo gJ Bernardo E Ramirez C | 2006 | Journal of the American College of Cardiology2006，48，： | 1 |
| 11 | ABEONA monitored traffic:VANET-assisted cooperative traffic congestion forecasting显示文摘 | Gramaglia M Calderon M Bernardos C J | 2014 | Vehicular Technology Magazine IEEE2014，9，2： | 1 |
| 12 | A comparative analysis of alternative models to predict the tensile strength of untreated and surface oxidized carbon fibers显示文摘 | PAIVA M C BERNARDO C A EDIE D D | 2001 | Carbon2001，，39： | 1 |
| 13 | Judicious resection and radio surgery for parasagittal meningiomas:outcome from amulticenter review显示文摘 | DOUGLAS K JOHN C F BERNARDO P | 1998 | Neurosurgery1998，43，2： | 1 |
| 14 | Subinhibitory quinupristin/dalfopristin attenuates virulence of Staphylococcus aureus 显示文摘 | Koszczol C Bernardo K Kronke M | 2006 | J Antimicrob Chemother2006，58，3： | 1 |
| 15 | Pellet: A practical OWL-DL reasoner显示文摘 | SIRIN E PARSIA B BERNARDO E C | 2007 | Web Semantics: Science Services and A- gents on the World Wide Web2007，5，2： | 1 |
| 16 | Design and Experimental Evaluation of a Route Optimisation So- lution for NEMO显示文摘 | CALDERON M BERNARDOS C BAGNULO M | 2006 | IEEE Journal on Selected Areas in Communications2006，24，9： | 1 |
| 17 | Genome-wide selection in oil palm: increasing selection gain per unit time and cost with small populations显示文摘 | Wong C K Bernardo R | 2008 | Theoretical and Applied Genetics2008，116，116： | 1 |
| 18 | Complex behavior in switching power converters显示文摘 | Tse C K Bernardo M D | 2002 | Proceedings of the IEEE2002，90，5： | 1 |
| 19 | Role of sulfur in the production of carbon fibers in the vapor phase显示文摘 | TIBBETTS G G BERNARDO C A GORKEWCOZ D W | 1994 | Carbon1994，32，4： | 1 |
| 20 | Diaphragmmatic eventration:long-term follow-up and results of open-chest plicature显示文摘 | Calvinho P Bastos C Bernardo JE | | 0，，05： | 1 |
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