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| 1 | Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats显示文摘AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU)to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats(median weight,235 g)were used in this study.The rats were fed with standard laboratory food and given tap water ad libitum.The animals were divided into three groups: Group 1:Control group(chemotherapy was not administered),Group 2:Intraperitoneally(IP)administered 5-FU group(chemotherapy was administered IP to animals at a dose of 20 mg/kg daily during the 5 d preceeding surgery),Group 3:Intravenously(IV)administered 5-FU group.Chemotherapy was administered via the penil vein,using the same dosing scheme and duration as the second group.After a 3-d rest to minimize the side effects of chemotherapy,both groups underwent surgery.One centimeter of colon was resected 2 cm proximally from the peritoneal reflection,thensutured intermittently and subsequently end-to-end anastomosed.In each group,half the animals were given anaesthesia on the 3rd postoperative(PO)day and the other half on the 7th PO day,for in vivo analytic procedures.The abdominal incisions in the rats were dissected,all the new and old anastomotic segments were clearly seen and bursting pressures of each anastomotic segment,tissue hydroxyproline levels and DNA content were determined to assess the histologic tissue repair process. RESULTS:When the IV group was compared with the IP group,bursting pressures of the anastomotic segments on the 3rd and 7th PO days,were found to be significantly decreased,hydroxyproline levels at the anastomotic segment on the 7th PO day were significantly decreased(P<0.01). CONCLUSION:In this study,we conclude that early preoperative 5-FU,administered IV,negatively affects wound healing.However,IP administered 5-FU does not negatively affect wound healing. | Leyla Ozel M Sefa Ozel Ahmet Burak Toros Melih Kara Kemal Sirri Ozkan Gurkan Tellioglu Osman Krand Meral Koyuturk Ibrahim Berber | 2009 | World Journal of Gastroenterology2009，15，33： | 7 |
| 2 | Qua- ternary ammonium compound as bacteri- cide in hide brine curing and presoaking processes 显示文摘 | Veyselova C Birbir M Berber D | 2012 | Journal of the American Leather Chemists Association2012，107，10： | 1 |
| 3 | Blind multiuser detector for chaos-based CDMA using support vetor machine显示文摘 | Kao J W Berber S M Kecmari V | 2010 | IEEE Transac2010，21，8： | 1 |
| 4 | Automatic generation of production scheduling models in single stage multi-product batch plants: Some examples显示文摘 | Berber R Yuceer M Ozdemir Z | 2007 | Mathematical and Computer Modelling2007，46，： | 1 |
| 5 | In Vitro Evaluation of the Antimicrobial Activity of Chlorhexidine and Sodium Hypochlorite显示文摘 | Vianna M E Gomes B Berber V B | 2004 | Oral Surg Oral Med Oral Pathol2004，97，： | 1 |
| 6 | Robotic posterior retroperitoneal adrenalectomy:operative technique显示文摘 | Berber E Mitchell J Milas M | 2010 | Archives of Surgery2010，145，8： | 1 |
| 7 | Efficacy and ton erability of vardenafil in men with mild depression and erectile dysfunction:the depression-related improvement with vardenafil {or erectile response study显示文摘 | ROSEN R SHABSIGH R BERBER M | 2006 | Am J Psychiatry2006，163，1： | 1 |
| 8 | The effect of vascular en- dothelial growth factor overexpression in experimental necrotizing ente- rocolitis显示文摘 | Karatepe HO Kilincaslan H Berber M | 2014 | Pediatr Surg Int2014，30，3： | 1 |
| 9 | Resection versus laparoscopic radiofrequency thermal ablation of solitary colorectal liver metastasis显示文摘 | Berber E Tsinberg M Tellioglu G | 2008 | J Gastrointest Surg2008，12，11： | 1 |
| 10 | An automated method for BER characteristics measurement显示文摘 | Berber S M | 2004 | IEEE Trans on Instrumentation and Measurement2004，53，2： | 1 |
| 11 | Laparoscopic radiof- requency ablation of neuroendocrine liver metastases: a lO-year experience evaluating predictors of survival 显示文摘 | Mazzaglia PJ Berber E Milas M | 2007 | Surgery2007，142，1： | 1 |
| 12 | Value of intraoperative parathyroid hormone monitoring显示文摘 | Sharma J Milas M Berber E | 2008 | Ann Surg Oncol2008，15，2： | 1 |
| 13 | Blind Multiuser Detector for Chaos-Based CDMA Using Support Vector Machine 显示文摘 | Kao J W Berber S M Kecman V | 2010 | IEEE Transactions on Neural Networks2010，21，8： | 1 |
| 14 | Nonconvulsive status epilepticus during childhood: clinical and electroencephalographic features显示文摘 | Yilmaz Y Onultan O Berber M | 2008 | Turk J Pediatr2008，50，5： | 1 |
| 15 | Interferon-gamma gene +874T-A polymorphism is associated with tuberculosis and gamma in- terferon response显示文摘 | Sallakci N Coskun M Berber Z | 2007 | Tuberculosis2007，87，3： | 1 |
| 16 | The effectof vascular endothelial growth factor overexpression in experimental necrotizing enterocolitis显示文摘 | Karatepe HO Kilincaslan H Berber M | 2014 | Pediatr Surg Int2014，30，3： | 1 |
| 17 | Resection versus laparoscopic radiofrequency thermal ablation of solitary colorectal liver metastasis显示文摘 | BERBER E TSINBERG M TELLIOGLU G | 2008 | J Gastrointest Surg2008，12，11： | 1 |
| 18 | Resection versus laparoscopic radiofrequency thermal ablation of solitary colorectal liver metastasie显示文摘 | Berber E Tsinberq M Tellioglu G | 2006 | J Gastrointest Surq2006，12，11： | 1 |
| 19 | Cloning and Nucleotide Se - quences of the Topisomerase Ⅳ par C and par E Genes of Mycoplasma hominis 显示文摘 | BERBER C M CHARRON A BOVE J M | 1998 | Antimicrob Agents and chemother1998，42，9： | 1 |
| 20 | Enhancement of platinum mass activity on the surface of Polymer-wrapped carbon nanotube-based fuel cell electrocatalysts显示文摘 | Hafez I H Berber M R Fujigaya T | 2014 | Scientific Reports2014，4，： | 1 |
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