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| 1 | QT prolongation is associated with increased mortality in end stage liver disease显示文摘AIM To determine the prevalence of QT prolongation in a large series of end stage liver disease(ESLD) patients and its association to clinical variables and mortality.METHODS The QT interval was measured and corrected for heart rate for each patient,with a prolonged QT cutoff defined as QT > 450 ms for males and QT > 470 ms for females.Multiple clinical variables were evaluated including sex,age,serum sodium,international normalized ratio,creatinine,total bilirubin,beta-blocker use,Model for EndStage Liver Disease(MELD),MELD-Na,and etiology of liver disease. RESULTS Among 406 ESLD patients analyzed,207(51.0%) had QT prolongation. The only clinical variable associated with QT prolongation was male gender(OR = 3.04,95%CI:2.01-4.60,P < 0.001). During the study period,187patients(46.1%) died. QT prolongation was a significant independent predictor of mortality(OR = 1.69,95%CI:1.03-2.77,P = 0.039). In addition,mortality was also associated with viral etiology of ESLD,elevated MELD score and its components(P < 0.05 for all). No significant reversibility in the QT interval was seen after liver transplantation. CONCLUSION QT prolongation was commonly encountered in an ESLD population,especially in males,and served as a strong independent marker for increased mortality in ESLD patients. | Sun Moon Kim Bennet George Diego Alcivar-Franco Charles L Campbell Richard Charnigo Brian Delisle Jonathan Hundley Yousef Darrat Gustavo Morales Samy-Claude Elayi Alison L Bailey | 2017 | World Journal of Cardiology2017，9，4： | 3 |
| 2 | 选择性头部降温对胎羊缺血性脑损伤纹状体神经元凋亡和星形胶质细胞增殖的影响显示文摘目的研究选择性头部降温对缺血性脑损伤胎羊纹状体神经元凋亡和星形胶质细胞增殖的影响。方法胎羊于妊娠117~124d时通过双侧颈动脉阻塞30min造成双侧脑缺血损伤,损伤后将胎羊随机分为:损伤组(n=10)、2h低温组(损伤后2h开始亚低温治疗,n=7)和6h低温组(损伤后6h开始亚低温治疗,n=8),另设正常对照组(n=5)。通过冷循环水进行选择性头部降温,取脑组织用免疫组化法检测胎羊纹状体caspase-3(半胱天冬氨酸酶-3),GFAP(胶质纤维酸性蛋白)和PCNA(增殖细胞核抗原)的表达。结果①纹状体神经元凋亡:正常对照组中,caspase-3表达极少(11.00±13.77),损伤组caspase-3免疫阳性细胞为177.70±48.69,明显增加(P=0.000),损伤后2h治疗组(54.14±39.44,P=0.000)和损伤后6h治疗组(122.43±52.36,P=0.017)均能减少caspase-3免疫阳性细胞。②纹状体星形胶质细胞增殖:与正常对照组(163.40±21.98)相比,缺血性脑损伤组的GFAP免疫阳性细胞明显增多(433.25±66.69,P=0.000),损伤后2h开始亚低温治疗(219.50±35.31,P=0.000)和损伤后6h开始亚低温治疗(272.50±86.20,P=0.000)均能减少GFAP免疫阳性细胞。③纹状体PCNA阳性细胞的表达:在正常对照组中,PCNA免疫阳性细胞较少,为153.40±12.46,缺血性脑损伤组的PCNA免疫阳性细胞明显增多(353.70±45.60,P=0.000),损伤后2h开始亚低温治疗(187.14±26.26,P=0.000)和损伤后6h开始亚低温治疗(230.25±67.46,P=0.000)均能减少PCNA免疫阳性细胞。结论亚低温可以抑制纹状体神经元的凋亡和星形胶质细胞的增殖,该作用可能为选择性头部降温的脑保护作用机制之一。 | 骆菲 曹云 Guan J Gunn AJ Bennet L George S Gluckman PD 杨毅 陈莲 | 2007 | 复旦学报(医学版)2007，34，4： | 2 |
| 3 | Mechanisms of hypotherrn neuroprotection显示文摘 | Drury PP Bennet L Gunn AJ | 2010 | Semin Fetal Neonatal Med2010，1，： | 1 |
| 4 | Effects of hypoxia on urinary organic acid and hypoxanthine excretion in fetal sheep显示文摘 | Walker V Bennet L Mills GA | 1996 | Pediatr Res1996，40，： | 1 |
| 5 | The processing of pseudorabies virus glycoprotein gX in infected cells and in an unifected cell line 显示文摘 | Bennet L M Timmins J G Thomsen D R | 1986 | Virology1986，155，2： | 1 |
| 6 | Neighborhood deprivation and ineq- uities in coronary heart disease among patients with diabetes mellitus : A multilevel study of 334,000 patients 显示文摘 | Chaikiat A Li X Bennet L | 2012 | Health Place2012，18，4： | 1 |
| 7 | Insulin like growth factor(IGF)-1 suppresses oligodendrocyte caspase-3 activation and increases glial proliferation after ischemia in near-term fetal sheep显示文摘 | Cao Y Gunn AJ Bennet L | 2003 | Cereb Blood Flow Metab2003，23，6： | 1 |
| 8 | Worse glycae- mic control in LADA patients than in those with type 2 diabetes, despite a longer time on insulin therapy 显示文摘 | Andersen CD Bennet L Nystrom L | 2013 | Dia- betologia2013，56，2： | 1 |
| 9 | Cerebral hypothermia is not neuro-protective when started after postischemic seizures in fetalsheep显示文摘 | GUNN AJ BENNET L | 2009 | Pediatr Res2009，4，6： | 1 |
| 10 | Insulin-like growth fac-tor(IGF)-1 suppresses oligodendrocyte caspase-3 activa-tion and increases glial proliferation after ischemia in near-term fetal sheep 显示文摘 | Cao Y Gunn AJ Bennet L | 2003 | J Cereb Blood Flow Metab2003，23，6： | 1 |
| 11 | Osteotomy for congenital elevation of the scapula (Sprengel' s deformity) 显示文摘 | McMurtry l Bennet GC Bradish C | 2003 | Bone Joint Surg Br2003，87，： | 1 |
| 12 | The effect of mild hypothermia on insulin-like growth factors after severe asphyxia in the preterm fetal sheep显示文摘 | Roelfsema V Gunn AJ Breier BH Quaedackers JS Bennet L | 2005 | J Soc Gynecol Invest2005，12，4： | 1 |
| 13 | DRASTIC:a standardized system for Evaluating ground water pollution potential using hydrological settings 显示文摘 | ALLER L BENNET T LEHR J H | 1987 | U S Environmental Protection Ada1987，37，13： | 1 |
| 14 | The effect of asphyxia on superior mesenteric artery blood flow in the premature sheep fetus显示文摘 | Bennet L Quaedackers JS Gunn A J | 2000 | JPediatr Surg2000，35，1： | 1 |
| 15 | Insulin-like growth factor-1and post-ischemic brain injury显示文摘 | Guan J Bennet L Gluckman PD | 2003 | Prog Neurobiol2003，70，6： | 1 |
| 16 | Atheroscleosis:An inflammatory disease显示文摘 | Weissberg P L Bennet! M R | 1999 | N Engl J Med1999，340，24： | 1 |
| 17 | Studying cancer-related fatigue: Report of the NCCN Scientific Research Committee 显示文摘 | MORTIblER J E BARSEVICK A M BENNET T C L | 2010 | J Natl Compr Cane Netw2010，8，12： | 1 |
| 18 | A Multilevel Analysis of Procedural Justice Context显示文摘 | Mnssholder K W Bennet N Martin C L | 1998 | Journal of Organizational Behaviour1998，，19： | 1 |
| 19 | Particulate characteristics and visual effects of the atmosphere at Research Triangle Park显示文摘 | Conner W D Bennet R L Weathers W S | 1991 | Journal of the Air and Waste Management Association1991，41，： | 1 |
| 20 | Cerebral hypothermia is not neuropretective when started after postisch- emic seizures in fetal sheep 显示文摘 | Gunn AJ Bennet L | 2009 | Pediatr Res2009，46，2： | 1 |
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