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5篇 您的检索式:作者名="BAYRAMOV A V"
    题名 作者 年代 出处 被引量
1Multiple noggins in vertebrate genome:cloning and expression of noggin2and noggin4 in Xenopus laevis显示文摘Eroshkin F M Ermakova G V Bayramov A V 2006Gene Expr Pattern2006,6,2:1
2Multiple noggins in vertebrate genome:cloning and expression of noggin2 and noggin4 in Xenopus laevis显示文摘Eroshkin F M Ermakova G V Bayramov A V 2006Gene Expr Pattern2006,6,2:1
3Vaginal vault leio- myoma: 25 years after total abdominal hysterectomy 显示文摘Yarci A Bayramov V Sukur Y E 2010J Minim Invasive Gynecol2010,17,1:1
4Multiple noggins in vertebrate genome: cloning and expression of noggin2 and noggin4 in Xenopus laevis 显示文摘EROSHKIN F M ERMAKOVA G V BAYRAMOV A V 2006Gene Expr Patterns2006,6,:1
5Effects of glucagon-like peptide 1 analogs in combination with insulin on myocardial infarct size in rats with type 2 diabetes mellitus显示文摘AIM To evaluate the effects of glucagon-like peptide-1 analogs(GLP-1 a) combined with insulin on myocardial ischemiareperfusion injury in diabetic rats.METHODS Type 2 diabetes mellitus(T2 DM) was induced in maleWistar rats with streptozotocin(65 mg/kg) and verified using an oral glucose tolerance test. After anesthesia, the left coronary artery was occluded for 40 min followed by 80 min reperfusion. Blood glucose level was measured during surgery. Rats were randomized into six groups as follows:(1) control rats;(2) insulin(0.1 U/kg) treated rats prior to ischemia;(3) insulin(0.1 U/kg) treated rats at reperfusion;(4) GLP-1 a(140 mg/kg) treated rats prior to ischemia;(5) GLP-1 a(140 mg/kg) treated rats at reperfusion; and(6) rats treated with GLP-1 a(140 mg/kg) prior to ischemia plus insulin(0.1 U/kg) at reperfusion. Myocardial area at risk and infarct size was measured planimetrically using Evans blue and triphenyltetrazolium chloride staining, respectively.RESULTS There was no significant difference in the myocardial area at risk among groups. Insulin treatment before ischemia resulted in a significant increase in infarct size(34.7% ± 3.4% vs 18.6% ± 3.1% in the control rats, P < 0.05). Post-ischemic administration of insulin or GLP-1 a had no effect on infarct size. However, pre-ischemic administration of GLP-1 a reduced infarct size to 12% ± 2.2%(P < 0.05). The maximal infarct size reduction was observed in the group treated with GLP-1 a prior to ischemia and insulin at reperfusion(8% ± 1.6%, P < 0.05 vs the control and GLP-1 a alone treated groups).CONCLUSION GLP-1 a pre-administration results in myocardial infarct size reduction in rats with T2 DM. These effects are maximal in rats treated with GLP-1 a pre-ischemia plus insulin at reperfusion.Vladislav A Zykov Taisiia P Tuchina Denis A Lebedev Irina B Krylova Alina Y Babenko Elvira V Kuleshova Elena N Grineva Alekber A Bayramov Michael M Galagudza 2018World Journal of Diabetes2018,9,9:1
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