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| 1 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 2 | Recombinant bovine somatotropin and clinical mastitis incidence, discarded milk following therapy and culling显示文摘 | JUDGE L J ERSKINE R J BARTLETT P C | 1997 | J Dairy Sci1997，80，： | 2 |
| 3 | Costs of clinical mastitis and mastitis prevention in dairy herds显示文摘 | Miller G Y Bartlett P C Lance S E | | 0，，： | 1 |
| 4 | Use of randomly amplified polymorphic DNA markers for the genetic analysis of relatedness and diversity in chickens and turkeys 显示文摘 | Smith E J Jones C P Bartlett J Nestor K E | 1996 | Poultry Sciences1996，75，2： | 1 |
| 5 | Linkage analysis of endogenous viral element 1, blue eggshell, and pea comb loci in chickens显示文摘 | Bartlett J R Jones C P Smith E J | 1996 | J Hered1996，87，1： | 1 |
| 6 | Linkage analysis of en- dogenous viral element 1, blue eggshell, and pea comb loci in chickens 显示文摘 | Bartlett J R Jones C P Smith E J | 1996 | J Hered1996，87，1： | 1 |
| 7 | Clinicalpresentation of hepatotoxicity-associated crizotinib inALK-positive(ALK+)advanced non-small cell lungcancer(NSCLC)显示文摘 | Schnell P Safferman A Z Bartlett C H | 2012 | J Clin Oncol2012，，： | 1 |
| 8 | Value of flow diagrams in reports of randomized controlled trials显示文摘 | Egger M Jüni P Bartlett C | 2001 | JAMA2001，285，15： | 1 |
| 9 | Localization and physical properties experiments conducted by Spirit at Gusev crater显示文摘 | Arvidson R E Anderson R C Bartlett P | 2004 | Science2004，305，5685： | 1 |
| 10 | Localization and physical property experiments conducted by Opportunity at Meridiani planum 显示文摘 | Arvidson R E Anderson R C Bartlett P | 2004 | Science2004，306，5702： | 1 |
| 11 | The fission yeast gene Pmtl+eneodes a DNA methyltransferase homologue显示文摘 | WILKINSON C R BARTLETT at NURSE P | 1995 | Nueleic Acids Res1995，23，2： | 1 |
| 12 | An electronic nose for the monitoring of the flavour of beers显示文摘 | Pearce T C Garner J W Friel S Bartlett P N Blair N | 1993 | Analyst1993，118，： | 1 |
| 13 | Metritis complex in Michigan Holstein-Friesian cattle: incidence, descriptive epidemiology and estimated economic impact显示文摘 | Bartlett P C Kirk J H Wilke M A | 1986 | Pre Vet Med1986，4，： | 1 |
| 14 | New Support Vector Algorithms显示文摘 | B Scholkopf R C Williamson P L Bartlett | 2000 | Neural Computation2000，12，5： | 1 |
| 15 | Economic comparison of the pyloro-omentopexy vs the roll-and-toggle procedure for treatment of left displacement of the abomasum in dairy cattle显示文摘 | Bartlett P C Kopcha M Coe P H | | 0，，08： | 1 |
| 16 | Effects of parenteral administration of vitamin E on health of periparturient dairy cows 显示文摘 | Erskine R J Bartlett P C Herdt T | 1997 | J Am Vet Med Assoc1997，211，： | 1 |
| 17 | Use of randomly amplified polymorphic DNA markers for the genetic analysis of relatedness and diversity in chickens and turkeys 显示文摘 | Smith E J Jones C P Bartlett J | 1996 | Poultry Science1996，75，： | 1 |
| 18 | Discovery of five conserved β-defensin gene clusters using a computational search strategy显示文摘 | Schutte B C Mitros J P Bartlett J A | 2002 | Proc Natl Acad Sci USA2002，99，4： | 1 |
| 19 | Elects of parental administration of vitamin E on health of periparturient dairy cows 显示文摘 | Erskine R J Bartlett P C Herdt T | 1997 | J AM Vet Med Assoc1997，211，4： | 1 |
| 20 | Structural risk minimization over data-dependent hierarchies显示文摘 | Shawe T J Bartlett P L Williamson R C | 1998 | IEEE Trans Inf Theory1998，44，： | 1 |
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