|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 3 | Application of machine learning in the fault diagnostics of air handling units显示文摘 | Najafi M Auslander D M Bartlett P L | 2012 | Applied Energy2012，96，： | 1 |
| 4 | Fault diagnostics of dynamic system operation using a fault tree based method显示文摘 | HURDLE E E BARTLETT L M ANDREWS J D | 2009 | Reliability Engineering and System Safety2009，94，9： | 1 |
| 5 | Fault diagnostics of dynamic system operation using a fault tree based method显示文摘 | HURDLE E E BARTLETT L M ANDREWS J D | 2009 | Reliability Engineering&System Safety2009，94，9： | 1 |
| 6 | An ordering heuristic to develop the binary decision diagram based on structural Importance显示文摘 | Bartlett L M Andrews J D | 2001 | Reliability Engineering and System Safety2001，72，： | 1 |
| 7 | Tissue expansion in children:a retrospective study of complications显示文摘 | ABRAMSON D L BARTLETT R A | 1997 | Ann Plast Surg1997，38，4： | 1 |
| 8 | Choosing a heuristic for the fault tree to binary decision diagram conversion using network显示文摘 | Bartlett L M Andrews J D | 2002 | IEEE on Reliability2002，51，3： | 1 |
| 9 | An ordering heuristic to develop the binary decision diagram based on structural importance显示文摘 | BARTLETT L M ANDREWS J D | 2001 | Reliability Engineering and System Safety2001，72，： | 1 |
| 10 | A Short-chain acyl-CoA dehydrogenase deficiency associated with a lipid-storage mvopathy and secondary carnitine deficiency显示文摘 | Turnbull D M Bartlett K Stevens D L | 1984 | New Eng J Med1984，311，： | 1 |
| 11 | Linking life-styles and energy use:A matter of time?显示文摘 | Schipper L Bartlett S Hawk A D | 2003 | Annual Review of Energy2003，14，1： | 1 |
| 12 | Choosing a heuristic for the 'fault tree to binary decision diagram' conversion, using neural networks显示文摘 | BARTLETT L M ANDREWS J D | 2002 | IEEE Transactions on Reliability2002，51，3： | 1 |
| 13 | An adenosine A(2A)agonistinjected in the nucleus of the solitary tract prolongs the laryngeal chemoreflex by a GABAergic mechanism in decerebrate piglets显示文摘 | DUY P M XIA L BARTLETT D JR | 2010 | Exp Physiol2010，95，7： | 1 |
| 14 | 显示文摘 | Comeau D L Bartlett R J | 1993 | Chem Phys Lett1993，，207： | 1 |
| 15 | Bilateral nephrectomy with concomitant renal graft transplantation for autosomal dominant polycystic kidney disease显示文摘 | Olassman D T Nipkow L Bartlett S T | 2000 | J Urol2000，164，31： | 1 |
| 16 | Linking life - styles and energy use: A matter of time? 显示文摘 | Sehipper L Bartlett S Hawk D Vine E | 1989 | Annual Review of Energy1989，14，： | 1 |
| 17 | A prospective analysis of plasma evdostatin levels in colorectal patients with liver metastases 显示文摘 | Feldman A L Alexander H R Jr Bartlett D L | 2001 | Ann Surg Oncol2001，8，9： | 1 |
| 18 | Recent advances in topical ophthalmic drug delivery with lipid- based nanocarriers 显示文摘 | Gan L Wang J Jiang M Bartlett H Ouyang D Eperjesi F | 2013 | Drug Discov Today2013，18，56： | 1 |
| 19 | Isolated hepatic perfusion with tumor necrosis factor and melphalan for unresectable cancers confined to the liver显示文摘 | ALEXANDER H R J R BARTLETT D L LIBUTTI S K | 1998 | J Clin Oncol1998，16，4： | 1 |
| 20 | A prospective analysis of plasma endostatin levels in eoloreetal cancer patients with liver metastases 显示文摘 | Feldman A L Alexander H R J r Bartlett D L | 2001 | Ann Surg Oncol2001，8，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员