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| 1 | Pathogenesis and management issues for non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease (NAFLD) has, although it is a very common disorder, only relatively recently gained broader interest among physicians and scientists. Fatty liver has been documented in up to 10 to 15 percent of normal individuals and 70 to 80 percent of obese individuals. Although the pathophysiology of NAFLD is still subject to intensive research, several players and mechanisms have been suggested based on the substantial evidence. Excessive hepatocyte triglyceride accumulation resulting from insulin resistance is the first step in the proposed 'two hit' model of the pathogenesis of NAFLD. Oxidative stress resulting from mitochondrial fatty acids oxidation, NF-κB-dependent inflammatory cytokine expression and adipocytokines are all considered to be the potential factors causing second hits which lead to hepatocyte injury, inflammation and fibrosis. Although it was initially believed that NAFLD is a completely benign disorder, histologic follow-up studies have showed that fibrosis progression occurs in about a third of patients. A small number of patients with NAFLD eventually ends up with end-stage liver disease and even hepatocellular carcinoma. Although liver biopsy is currently the only way to confirm the NAFLD diagnosis and distinguish between fatty liver alone and NASH, no guidelines or firm recommendations can still be made as for when and in whom it is necessary. Increased physical activity, gradual weight reduction and in selected cases bariatric surgery remain the mainstay of NAFLD therapy. Studies with pharmacologic agents are showing promising results, but available data are still insufficient to make specific recommendations; their use therefore remains highly individual. | Marko Duvnjak Ivan Leroti Neven Bari Vedran Tomai Lucija Virovi Juki Vedran Velagi | 2007 | World Journal of Gastroenterology2007，13，34： | 74 |
| 2 | Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease显示文摘High prevalence of non-alcoholic fatty liver disease (NAFLD) and very diverse outcomes that are related to disease form and severity at presentation have made the search for noninvasive diagnostic tools in NAFLD one of the areas with most intense development in hepatology today.Various methods have been investigated in the recent years,including imaging methods like ultrasound and magnetic resonance imaging,different forms of liver stiffness measurement,various biomarkers of necroinflammatory processes (acute phase reactants,cytokines,markers of apoptosis),hyaluronic acid and other biomarkers of liver fibrosis.Multicomponent tests,scoring systems and diagnostic panels were also developed with the purposes of differentiating non-alcoholic steatohepatitis from simple steatosis or discriminating between various fibrosis stages.In all of the cases,performance of noninvasive methods was compared with liver biopsy,which is still considered to be a gold standard in diagnosis,but is by itself far from a perfect comparative measure.We present here the overview of the published data on various noninvasive diagnostic tools,some of which appear to be very promising,and we address as well some of still unresolved issues in this interesting field. | Neven Bari Ivan Leroti Lea Smiri-Duvnjak Vedran Tomai Marko Duvnjak | 2012 | World Journal of Gastroenterology2012，18，30： | 7 |
| 3 | Genetic polymorphisms in non-alcoholic fatty liver disease:Clues to pathogenesis and disease progression显示文摘The spectrum of non-alcoholic fatty liver disease(NAFLD) ranges from simple steatosis through steatohepatitis to advanced f ibrosis and cirrhosis.Although the reason why only a minority of patients develop progressive forms of disease still remains largely unclear,recent research has identified genetic factors as a possible basis for this variation in disease presentation.Most of the studies have been focused on f inding associations between advanced disease forms and selected single nucleotide polymorphisms in genes encoding various proteins involved in disease pathogenesis.Although there are many limitations regarding the study design and interpretation of published data,further carefully planned studies together with implementation of new genetic technologies will likely bring new insights into disease pathogenesis and potential benefits to the management of patients with NAFLD. | Marko Duvnjak Neven Bari Vedran Tomai Ivan Leroti | 2009 | World Journal of Gastroenterology2009，15，48： | 4 |
| 4 | Induced re - generation of en- dometrium following curettage for aboion: a comparative study显示文摘 | Farhi J Bar - Hava I Homburg Pt | 1993 | Hum Reprod1993，8，7： | 1 |
| 5 | Immediate ambula- tion after embryo transfer: a prospective study 显示文摘 | Bar - Hava I Kerner R Yneli R | 2005 | Fertil Steri12005，83，3： | 1 |
| 6 | The effect of Ras inhibition on the proliferation,apoptosis and matrix metalloproteases activity in rat hepatic stellate cells显示文摘 | ZVIBEL I BAR ZOHAR D KLOOG Y | 2008 | Dig Dis Sci2008，53，4： | 1 |
| 7 | Unified Approach to Inertial Navigation System Error Modeling显示文摘 | Goshen Meskin D Bar Itzhack I Y | 1992 | Journal Guidance Control and Dynamics1992，15，3： | 1 |
| 8 | Immediate ambulation afterembryo transfer:a prospective study显示文摘 | Bar - Hava I Kemer R Yoeli R | 2005 | Fertil Steril2005，83，3： | 1 |
| 9 | Pharmacokinetics of the progesterone con- taining vaginal tablet and its use in assisted reproduction 显示文摘 | Levy T Yairi Y Bar Hava I | 2000 | Ster- oids2000，65，1011： | 1 |
| 10 | Perampanel Study 207: long-term open-label evaluation in patients with epilepsy 显示文摘 | Rektor I Krauss GL Bar M | 2012 | Acta NeurolScand2012，126，4： | 1 |
| 11 | Sodium and chloride requirements of the 7-9-week-old broiler显示文摘 | HURWITZ S COHEN I BAR A | 1974 | Poultry Science1974，53，1： | 1 |
| 12 | New flame retardant systems for styrenic plastics and method of preparation 显示文摘 | Finberg I Bar Yaakov Y Georlette P | 1999 | Polymer Degradation and Stability1999，64，3： | 1 |
| 13 | Bone morphogenetic protein-2 Induces the expression of cementum at tachment- protein in human periodontal ligament clones 显示文摘 | Pitaru S Pritzki A Bar Kana I | 2002 | Connect Tissue Res2002，43，23： | 1 |
| 14 | Congenital chylothorax : clini cal course and prognostic significance 显示文摘 | Ergaz Z Bar - Oz B Yatsiv I | 2009 | Pcdiatr Puhnonol2009，44，8： | 1 |
| 15 | Circulating autoantibodies to endothelial progenitor cells: binding characteristics and association with risk factors for atherosclerosis 显示文摘 | George J Matucci - Cerinie M Bar I | 2014 | PLoS One2014，9，97： | 1 |
| 16 | Inertial navigation system aided by aircraft dynamics显示文摘 | KOIFMAN M BAR ITZHACK I Y | 1999 | IEEE Transactions on Control Systems Technology1999，7，4： | 1 |
| 17 | New evidence of risk factors for community-acquired pneumonia: a population-based study显示文摘 | Almirall J Bol'bar I Serra-Prat M | 2008 | EurRespirJ2008，31，6： | 1 |
| 18 | Knockout mice reveal a role for P2Y6 receptor in macrophages, endothelial cells, and vascular smooth muscle cells 显示文摘 | Bar I Guns PJ Metallo J | 2008 | Mol Pharmacol2008，74，3： | 1 |
| 19 | Predictive value of transvaginal sonography performed before routine diabno stichystero scopy for evaluation of infertility显示文摘 | Shalev J Meizner I Bar Hava I | 2000 | Fertil Steril2000，73，2： | 1 |
| 20 | Predictive value of transvaginal sonography performed before routine diabnostic hysterocopy for evaluation of infertility显示文摘 | Shalev J Meizner I Bar Hava I | 2003 | Fertil Steril2003，73，2： | 1 |
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