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| 1 | 高血压患者肾素血管紧张素系统阻断的血浆分子标志:肾损害与初发蛋白尿的新预测指标显示文摘蛋白尿是一个与心血管病密切相关的危险因素,也是一般人群的首位死亡原因。虽然已经明确肾素血管紧张素系统(renin-angiotensin system,RAS)阻断剂能延缓高血压患者初发蛋白尿进展、减少蛋白尿排出,但仍不能忽视高血压患者发生初发蛋白尿的比例。 | Baldan-Martin M Mourino-Alvarez L Gonzalez-Calero L Moreno-Luna R Sastre-Oliva T Ruiz-Hurtado G Segura J Lopez JA Vazquez J Vivanco F Alvarez-Llamas G Ruilope LM de la Cuesta F Barderas MG 赵狄 练桂丽 | 2016 | 中华高血压杂志2016，24，6： | 2 |
| 2 | Image registration by compression 显示文摘 | Bardera A Feixas M Boada I | 2010 | Information Sciences2010，180，7： | 1 |
| 3 | High expression of IL-13 receptor alpha2 in colorectal canceris associated with invasion, liver metastasis,and poor prog-nosis显示文摘 | Barderas R Bartolome RA Fernandez-Acenero MJ | 2012 | Cancer Res2012，72，： | 1 |
| 4 | Automatic transfer functions based on informational divergence显示文摘 | Ruiz M Bardera A Boada I | 2011 | IEEE Transactions on Visualization and Computer Graphics2011，17，12： | 1 |
| 5 | Image segmentation using excess entropy 显示文摘 | Bardera A Boada I Feixas M | 2009 | Journal of Signal Processing Systems2009，54，13： | 1 |
| 6 | A fast mutagenesis procedure to recover soluble and functional scFv containing amber stop eodons from synthetic and semisynthetic antibody libraries显示文摘 | Barderas R Shochat S Martinez-Torrecuadrada J | 2006 | J Immunol Methods2006，312，12： | 1 |
| 7 | Peptide epitopes of the Taenia solium antigen Ts8B2 are immunodominant in human and porcine cysticercosis 显示文摘 | Ferret E Mart nez-Eseribano JA Barderas ME | 2009 | Mol Biochem Parasitol2009，168，2： | 1 |
| 8 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 9 | Serological autoantibody profiling using protein arrays distinguish bladder cancer patients from contrals显示文摘 | Drenes-Pinero E Barderas R Rico D | 2009 | J Urol2009，181，4： | 1 |
| 10 | Serodiagnosis of African swine fever using the recombinant protein p30 expressed in insect larvae 显示文摘 | Barderas M G Wigdorovitz A Merelo F | 2000 | J Virol Methods2000，89，12： | 1 |
| 11 | Image seg-menta tion using excess entropy显示文摘 | BARDERA A BOADA I FEIXAS M | | 0，，03： | 1 |
| 12 | Atorvastatin modifies the protein profile of circulating human monocytes after an acute coronary syndrome 显示文摘 | Barderas M G Tunon J Darde V M | 2009 | Proteomics2009，9，7： | 1 |
| 13 | Image segmentation using information bottleneck method显示文摘 | BARDERA Anton RIGAU Jaume | 2009 | IEEE Transactions on Image Processing2009，18，7： | 1 |
| 14 | Image segmenta- tion using excess entropy显示文摘 | Bardera A Boada I Feixas M Sbert M | 2009 | Journal of Signal Processing Systems2009，54，13： | 1 |
| 15 | Image segmentation using excess entropy显示文摘 | Bardera A Boada I Feixas M | 2009 | Journal of Signal Processing Systems2009，54，13： | 1 |
| 16 | Image Segmentation Using Excess Entropy显示文摘 | A. Bardera I. Boada M. Feixas M. Sbert | | 0，，： | 1 |
| 17 | Automatic transfer functions based on informational divergence显示文摘 | RUIZ M BARDERA A BOADA I | 2011 | IEEE Trans on Visualization and Computer Graphics2011，17，12： | 1 |
| 18 | Depletion of high-abundance proteins in plasma by immunoaffinity subtraction for two-dimensional difference gel electrophoresis analysis显示文摘 | DARDE V M BARDERAS M G VIVANCO F | 2007 | Methods Mol Biol2007，357，： | 1 |
| 19 | Image seg- mentation using excess entropy 显示文摘 | BARDERA A BOADA I FEIXAS M | 2009 | Journal of Signal Processing Systems2009，54，13： | 1 |
| 20 | High - Dimensional Normalized Mutual Information for Image Registration using Random Lines显示文摘 | A Bardera M Feixas I Boada and M Sbert | 2006 | Proceedings of the Third International Workshop on Biomedical Image Registration 2006 (LNCS 4057 ) Utrecht Netherlands2006，2006，： | 1 |
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