|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Obesity and weight loss could alter the properties of adipose stem cells?显示文摘The discovery that adipose tissue represents an interesting source of multipotent stem cells has led to many studies exploring the clinical potential of these cells in cell-based therapies. Recent advances in understanding the secretory capacity of adipose tissue and the role of adipokines in the development of obesity and associated disorders have added a new dimension to the study of adipose tissue biology in normal and diseased states. Subcutaneous adipose tissue forms the interface between the clinical application of regenerative medicine and the establishment of the pathological condition of obesity. These two facets of adipose tissue should be understood as potentially related phenomena. Because of the functional characteristics of adipose stem cells, these cells represent a fundamental tool for understanding how these two facets are interconnected and could be important for therapeutic applications. In fact, adipose tissue stem cells have multiple functions in obesity related to adipogenic, angiogenic and secretory capacities. In addition, we have also previously described a predominance of larger blood vessels and an adipogenic memory in the subcutaneous adipose tissue after massive weight loss subsequent to bariatric surgery(ex-obese patients). Understanding the reversibility of the behavior of adipose stem cells in obeses and in weight loss is relevant to both physiological studies and the potential use of these cells in regenerative medicine. | Leandra S Baptista Karina R Silva Radovan Borojevic | 2015 | World Journal of Stem Cells2015，7，1： | 4 |
| 2 | Starting glargine in insulin-nave type 2 diabetic patients based on body mass index is safe显示文摘AIM:To evaluate the safety of four insulin titration algorithms in a homogeneous population of insulin-na ve type 2 diabetic patients.METHODS:We conducted a 24-wk,open,single-center study with 92 insulin-na ve type 2 diabetes patients who failed treatment with one or two oral drugs.The patients were randomized to one of the four following algorithms:LANMET(n=26)and LANMET PLUS(n=22)algorithms,whose patients received a fixed initial insulin dose of 10 U,and DeGold(n=23)and DeGold PLUS(n=21)algorithms,whose patients’initial insulin dose was based on their body mass index(BMI).In addition,patients in the PLUS groups had their insulin titrated twice a week from 2 to 8 U.In the other two groups,the titration was also performed also twice a week,but in a fixed increments of 2 U.The target fasting glucose levels for both groups was 100 mg/dL.RESULTS:There was no significant difference in efficacy parameters.There was no significant difference when comparing moderate hypoglycemia events in algorithms starting with a 10 U fixed dose and algorithms based on BMI.However,there was a significant increase in moderate hypoglycemia events among the PLUS treated patients when the LANMET and DeGold algorithms were compared with the 2 fast-titration PLUS algorithms.We observed 12 hypoglycemia events in the first group,which corresponded to 0.94 events/patient per year,and we observed 42 events in the second group,which corresponded to 2.81 events/patient per year(P<0.037).No further significant differences were observed when other comparisons between the algorithms were carried out.CONCLUSION:Starting insulin glargine based on BMI is safe,but fast titration algorithms increase the risk of moderate hypoglycemia. | Denise R Franco Juliana Baptista Fatima RM Abreu Risoneide B Batista Freddy G Eliaschewitz | 2014 | World Journal of Diabetes2014，5，1： | 2 |
| 3 | Do firms in clusters innovate more 显示文摘 | BAPTISTA R SWANN P | 1998 | Research Policy1998，27，： | 1 |
| 4 | A three-dimensional model of tidal currents in the mouth of the Tagus estuary显示文摘 | FORTUNATO A B BAPTISTA A M and LUETTICH R A | 1997 | Continental Shelf Research1997，17，14： | 1 |
| 5 | Mechanical behaviour of polypropylene reinforced sugarcane bagasse fibers composites显示文摘 | Cerqueira E F Baptista C A R P Mulinari D R | 2011 | Procedia Engineering2011，10，： | 1 |
| 6 | Computer aided learning versus standard lecture for undergraduate education in urology显示文摘 | Seabra D Srougi M Baptista R | 2004 | Journal Urology2004，171，3： | 1 |
| 7 | , Geographical clusters and innovation diffusion显示文摘 | Baptista R | 2001 | Technological Forecasting and Social Change2001，66，1： | 1 |
| 8 | Do Innovations Diffuse Faster within Geographical Clusters? 显示文摘 | BAPTISTA R | 2000 | International Journal of Industrial Organization2000，18，51： | 1 |
| 9 | A fluorimetric method based on changes in membrane potential for screening paralytic shellfish toxins in mussels 显示文摘 | LOUZAO M C VIEYTES M R BAPTISTA D E | 2001 | Analy Biochem2001，289，： | 1 |
| 10 | Do Firms in Clusters Innovate More 显示文摘 | Baptista R Swann G M P | 1998 | Research policy1998，27，： | 1 |
| 11 | Three and five axes milling of sculptured surfaces显示文摘 | Baptista R Simoes JFA | 2000 | Journal of Materials Processing Technology2000，，103： | 1 |
| 12 | Do Firms in Clusters Innovate More? 显示文摘 | Baptista R Swann P | 1998 | Reseach Policy1998，，3： | 1 |
| 13 | Concentrations ofendotoxins in waters around the island of montreal,and treatmentoptions显示文摘 | Gehr R Yribe PU Baptista IFDS | 2008 | Water Qual Res J Can2008，43，4： | 1 |
| 14 | Low-frequency fatigue at maximal and submaximalmuscle contractions 显示文摘 | Baptista R R Scheeren E M Macintosh B R | 2009 | Brazilian Journal of Medicaland Biological Research2009，42，4： | 1 |
| 15 | Do firms in clusters innovate more?显示文摘 | Baptista R Swann P | 1998 | Research Policy1998，27，5： | 1 |
| 16 | The diffusion of process innovations:a selective review显示文摘 | Baptista R | 1999 | International Journal of the Economics of Business1999，6，1： | 1 |
| 17 | Free-radical scavenging capacity and reducing power of wild edible mushrooms from northeast Portugal: Indi-vidual cap and stipe activity显示文摘 | Ferreira I C F R Baptista P Vilas-Boas M | 2007 | Food Chemistry2007，100，15： | 1 |
| 18 | Do Firms in Clusters Innovate More?显示文摘 | BAPTISTA R SWANN P | 1998 | Research Policy1998，27，5： | 1 |
| 19 | Cutting forces and wear analysis of Si3 N4 diamond coated tools in high speed machi- ning 显示文摘 | MARTINHO R P SILVA F J G BAPTISTA A P M | 2008 | Vacuum2008，82，12： | 1 |
| 20 | Concentrations of endotoxins in waters around the island of montreal and treatment options显示文摘 | Gehr R Yribe P U Baptista I F D S | 2008 | Water Qual Res J Can2008，43，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员