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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Cytokine chemokine expression in contused rat spinal cord显示文摘 | Lee YL Shih K Bao P | 2000 | Neurochem Int2000，36，45： | 2 |
| 3 | 纳米光子结构软膜紫外光固化纳米压印(英文)显示文摘紫外光固化纳米压印是实现纳米结构批量复制的一种新技术.其特点是低成本和高分辨,而且可以达到极高的套刻精度.为了得到大面积图案的均匀复制,可用聚二甲基硅氧烷(PDMS)制备透光的压印软模板.其母版图案可由高分辨率电子束曝光和反应离子刻蚀的方法在硅片基底上获得,然后用浇注的方法将图案转移到PDMS上.本实验特别发展了紫外光固化纳米压印适用于软膜压印的双层膜图型转移技术.该双层膜由廉价的光胶和聚甲基丙烯酸甲脂(PMMA)构成.对光胶层的压印可用普通的光学曝光仪实现.然后再将图案用反应离子刻蚀的方法转移到PMMA层中.为了证明方案的可行性,在两种不同材料的半导体基片上压印了三角晶格的光子晶体和准晶结构的图案,并用剥离的方法将它们转移到金属薄膜上,最后成功地进行了硅片刻蚀实验.相信这一纳米制做方法对大面积纳米光子结构和光学集成芯片的制造是普遍适用的. | SHI J WANG Z M BAO K PEROZ C BELOTTI M XU L P LUO C X SUN M H ZHANG B JI H OUYANG Q CHEN Y | 2006 | 纳米技术与精密工程2006，4，3： | 2 |
| 4 | Robust mult-loop PID controller design-a successive semi-definite programming approach显示文摘 | BAO J FORBES J F MCLELLAN P J | 1999 | Ind Eng Chem Process Des Dev1999，38，： | 2 |
| 5 | GSK-3β inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation显示文摘 | Carmichael J Sugars K L Bao Y P | 2002 | J Biol Chem2002，277，33： | 1 |
| 6 | Keratinocyte growth factor induces Akt kinase activity and inhibits Fas-mediated apoptosis in A549 lung epithelial cells显示文摘 | Bao S Wang Y Sweeney P | 2005 | Am J Physiol Lung Cell Mol Physiol2005，288，1： | 1 |
| 7 | Alkaline syenites in eastern Cathaysia (South China): Link to Permian-Triassic transtension显示文摘 | Wang Q Li J W Jian P Zhao Z H Xiong X L Bao Z W Xu J F Li C F Ma J L | 2005 | Emth Planet Sci Lett2005，230，34： | 1 |
| 8 | A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis显示文摘 | Shao F Merritt P M Bao Z | 2002 | Cell2002，109，： | 1 |
| 9 | Pain - related emotionsmodulate experimental pain perception and autonomic re-sponses 显示文摘 | Rainville P Bao QVH Chretien P | 2005 | Pain2005，118，3： | 1 |
| 10 | The development of reliability modeling and analysis tool based on stochastic Petri nets显示文摘 | Wang W P Gao Z L Bao S Y | 2010 | Ad- vanced Materials Research2010，，118120： | 1 |
| 11 | Bilberry extract protect restraint stress-induced liver damage through attenuating mitochondrial dysfunction 显示文摘 | Bao L Abe K Tsang P | 2010 | Fitoterapia2010，81，8： | 1 |
| 12 | MicroRNA-34a overcomes HGFmediated gefitinib resistance in EGFR mutant lung cancer cells partly by targeting MET显示文摘 | Zhou JY Chen X Zhao J Bao Z Chen X Zhang P | 2014 | Cancer Lett2014，351，2： | 1 |
| 13 | Modelling of a chemisorption refrigeration and power cogeneration system 显示文摘 | BAO H S WANG Y D ROSKILLY A P | 2014 | Applied Energy2014，119，： | 1 |
| 14 | Nonparametric Detection of FM Signals Using Time-frequency Ridge Energy显示文摘 | Shui P L Bao Z Su H T | 2008 | IEEE Trans on SP2008，56，5： | 1 |
| 15 | Quadruple-step line generation 显示文摘 | Bao P G Rokne J G | 1989 | Computers & Graphics1989，13，2： | 1 |
| 16 | Denoising by spatial correlation thresholding 显示文摘 | Zhang L Bao P | 2003 | IEEE Transactions on Circuits and Systems for Video Technology2003，13，6： | 1 |
| 17 | Interactive effects of common beta2-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor function显示文摘 | Bao X Mills P J Rana B K | 2005 | Hypertension2005，46，2： | 1 |
| 18 | Endovascular graft exclusion for thoraoric dissections 显示文摘 | JING Z P FENG X BAO J M | 2000 | Journal of Medical Colleges of PLA2000，15，： | 1 |
| 19 | Threshold analysis in wavelet-based de-noising 显示文摘 | Zhang L Bao P Pan Q | 2001 | IEE Electronics Letters2001，37，24： | 1 |
| 20 | Gold nanoparticle-based detection of genomic DNA targets on microarrays using a novel optical detection system显示文摘 | Storhoff J J Marla S S Bao P | 2004 | Biosens Bioelectron2004，19，8： | 1 |
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