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| 1 | Preliminary results of Thymosin-a1 versus interferon-α treatment in patients with HBeAg negative and serum HBV DNA positive chronic hepatitis B显示文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . | Lin Zhuang Jing You Bao Zhang Tang Su Ying Ding Kui Hua Yan Dan Peng Yan Mei Zhang Lu Zhang ~1Department of Hepatology,Kunming Third Municipal Peoples Hospital,Kunming 650041,Yunnan Province,China ~2Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 22 |
| 2 | Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity显示文摘感觉神经原被不同发信号的网络和接受特征区分。因此,感觉神经原类型能被连接基于 transcriptome 的神经原与感觉显型打字定义。这里,我们分类老鼠的 somatosensory 神经原由高范围的单个房间的定序 RNA 的背面的根中心(DRG )(10 950 ±1 218 基因每神经原) 并且神经原基于尺寸的层次聚类。而且,对皮肤的刺激作出回应的单个 DRG 神经原被记录用一在里面 vivo 整个房间的补丁夹钳技术并且由神经原类型分类基因标记。小直径 DRG 神经原被分类进低阀值的 mechanoreceptor 的一种类型和 mechanoheat nociceptors (MHN ) 的五种类型。每 MHN 类型进一步被分成二种子类型。大 DRG 神经原被分成四种类型,包括表示联系 BAI1 的蛋白质 2-like 的 neurexophilin 1 快车 MHN 和机械 nociceptors (MN ) 1 (Baiap2l1 ) 。表示 trafficking 蛋白质粒子建筑群 3-like 和 Baiap2l1 显著的 MN 的 Mechanoreceptors 各被细分进二种子类型。这些结果为编目 somatosensory 神经原和他们的 transcriptome 数据库提供一个新系统。 | Chang-Lin Li Kai-Cheng Li Dan Wu Yan Chen Hao Luo Jing-Rong Zhao Sa-Shuang Wang Ming-Ming Sun Ying-Jin Lu Yan-Qing Zhong Xu-Ye Hu Rui Hou Bei-Bei Zhou Lan Bao Hua-Sheng Xiao Xu Zhang | 2016 | Cell Research2016，26，1： | 21 |
| 3 | Improved normalization method for ductile fracture toughness determination based on dimensionless load separation principle显示文摘This study successfully deals with the inhomogeneous dimension problem of load separation assumption, which is the theoretical basis of the normalization method. According to the dimensionless load separation principle, the normalization method has been improved by introducing a forcible blunting correction. With the improved normalization method, the J-resistance curves of five different metallic materials of CT and SEB specimens are estimated. The forcible blunting correction of initial crack size plays an important role in the J-resistance curve estimation, which is closely related to the strain hardening level of material. The higher level of strain hardening leads to a greater difference in JQ determined by different slopes of the blunting line.If the blunting line coefficient recommended by ASTM E1820-11 is used in the improved normalization method, it will lead to greater fracture resistance than that processed by the blunting line coefficient recommended by ISO 12135-2002. Therefore, the influence of the blunting line on the determination of JQ must be taken into full account in the fracture toughness assessment of metallic materials. | Chen Bao Lixun Cai Kaikai Shi Chen Dan Yao Yao | 2015 | Acta Mechanica Solida Sinica2015，28，2： | 10 |
| 4 | Generation of GGTA1 biallelic knockout pigs via zinc-finger nucleases and somatic cell nuclear transfer显示文摘Genetically modified pigs are valuable models of human disease and donors of xenotransplanted organs.Conventional gene targeting in pig somatic cells is extremely inefficient.Zinc-finger nuclease(ZFN)technology has been shown to be a powerful tool for efficiently inducing mutations in the genome.However,ZFN-mediated targeting in pigs has rarely been achieved.Here,we used ZFNs to knock out the porcineα-1,3-galactosyl-transferase(GGTA1)gene,which generates Gal epitopes that trigger hyperacute immune rejection in pig-to-human transplantation.Primary pig fibroblasts were transfected with ZFNs targeting the coding region of GGTA1.Eighteen mono-allelic and four biallelic knockout cell clones were obtained after drug selection with efficiencies of 23.4%and 5.2%,respectively.The biallelic cells were used to produce cloned pigs via somatic cell nuclear transfer(SCNT).Three GGTA1 null piglets were born,and one knockout primary fibroblast cell line was established from a cloned fetus.Gal epitopes on GGTA1 null pig cells were completely eliminated from the cell membrane.Functionally,GGTA1 knockout cells were protected from complement-mediated immune attacks when incubated with human serum.This study demonstrated that ZFN is an efficient tool in creating gene-modified pigs.GGTA1 null pigs and GGTA1 null fetal fibroblasts would benefit research and pig-to-human transplantation. | BAO Lei CHEN HaiDe JONG UiMyong RIM CholHo LI WenLing LIN XiJuan ZHANG Dan LUO Qiong CUI Chun HUANG HeFeng ZHANG Yan XIAO Lei FU ZhiXin | 2014 | Science China(Life Sciences)2014，57，2： | 9 |
| 5 | Cross-correlation matrix Root-MUSIC algorithm for bistatic multiple-input multiple-output radar显示文摘A novel Root-MUSIC algorithm based on cross-correlation matrix is proposed to estimate the direction of arrival(DOA) and direction of departure(DOD) for the bistatic multiple-input multiple-output(MIMO)radar. In the algorithm, the cross-correlation matrix is first constructed by using the received data which are arranged according to the transmit array and the receive array, respectively. And the DOAs and DODs are estimated independently employing cross-correlation Root-MUSIC algorithms without eigendecomposition,where the null spaces are constructed with a linear operation of the cross-correlation matrices. Secondly the pair-matching of DOAs and DODs is accomplished by solving an angle estimate optimization. The effectiveness of the proposed method is verified through numerical simulations, and it is shown that the proposed method can provide more accurate angle estimation with small computational complexity than conventional eigendecomposition algorithms. | QIN GuoDong BAO Dan LIU GaoGao LI Peng | 2015 | Science China(Information Sciences)2015，58，2： | 8 |
| 6 | Multi-shelled TiO2/Fe2TiO5 heterostructured hollow microspheres for enhanced solar water oxidation显示文摘 | Muhammad Waqas Yanze Wei Dan Mao Jian Qi Yu Yang Bao Wang Dan Wang | 2017 | Nano Research2017，10，11： | 6 |
| 7 | Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1显示文摘Caspase-11 is a key upstream modulator for activation of inflammatory response under pathological conditions. In this study, we investigated the roles of caspase-11 in the maturation of interleukin-1β (IL-1β) and development of renal interstitial fibrosis in vivo and in vitro. Mice were subjected to unilateral ureteral obstruction (UUO). The mice were treated with either caspase-11 inhibitor wedelolactone (Wed, 30 mg/kg/day, ig) for 7 days or caspase-11 siRNA (10 nmol/20 g body weight per day, iv) for 14 days. The mice were euthanized on day 14, their renal tissue and blood sample were collected. We found that the obstructed kidney had significantly higher caspase-11 levels and obvious tubular injury and interstitial fibrosis. Treatment with Wed or caspase-11 siRNA significantly mitigated renal fibrosis in UUO mice, evidenced by the improved histological changes. Furthermore, caspase-11 inhibition significantly blunted caspase-1 activation, IL-ip maturation, transforming growth factor-p (TGF-P), fibronectin, and collagen I expressions in the obstructed kidney. Renal tubular epithelial NRK-52E cells were treated in vitro with angiotensin (Ang, 1 pmol/L), which stimulated caspase-11 activation and IL-ip maturation. Treatment with IL-1β (20ng/ml) significantly increased the expression of TGF-β, fibronectin, and collagen I in the cells. Ang ll-induced expression of TGF-β, fibronectin, and collagen I were suppressed by caspase-11 siRNA or Wed. Finally, we revealed using co-immunoprecipitation that caspase-11 was able to interact with caspase-1 in NRK-52E cells. These results suggest that caspase-11 is involved in UUO-induced renal fibrosis. Elevation of caspase-11 in the obstructed kidney promotes renal fibrosis by stimulating caspase-1 activation and IL-1β maturation. | Nai-jun Miao Hong-yan Xie Dan Xu Jian-yong Yin Yan-zhe Wang Bao Wang Fan Yin Zhuan-li Zhou Qian Cheng Pan-pan Chen Li Zhou Hong Xue Wei Zhang Xiao-xia Wang Jun Liu Li-min Lu | 2019 | Acta Pharmacologica Sinica2019，40，6： | 5 |
| 8 | 青年型开角型青光眼的中国家系的新型Myocilin基因突变显示文摘目的:探讨某中国家系青年型开角型青光眼(JOAG)的致病基因。
方法:在一个青光眼家系中,三代人中患JOAG或高眼压。我们筛查了6位家族成员Myocilin(MYOC)和 optineurin(OPTN)的突变和apolipoprotein E的多态性,2位患有JOAG,2位患有高眼压,2位无症状。正常对照组包括200位与本家系无关联的受试者。用编码野生型或变异性 MYOC 互补 DNA 的表达载体转染cos-7细胞系。细胞内或分泌的MYOC蛋白用Western法进行检测。 | Bao Jian Fan Dexter Y. L Leung Dan Yi Wang Stéphane Vincent Raymond Pancy O. S. Tam Dennis S. C. Lam Chi Pui Pang 王婷(译) | 2006 | 美国医学会眼科杂志(中文版)2006，18，4： | 5 |
| 9 | Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain显示文摘Peripheral nerve injury could lead to chronic neuropathic pain.Understanding transcriptional changes induced by nerve injury could provide fundamental insights into the complex pathogenesis of neuropathic pain.Gene expression profiles of dorsal root ganglia(DRG)in neuropathic pain condition have been studied.However,little is known about transcriptomic changes in individual DRG neurons after peripheral nerve injury. | Kaikai Wang Sashuang Wang Yan Chen Dan Wu Xinyu Hu Yingjin Lu Liping Wang Lan Bao Changlin Li Xu Zhang | 2021 | Cell Research2021，31，8： | 5 |
| 10 | c-Myc promotes tubular cell apoptosis in ischemia-reperfusion-induced renal injury by negatively regulating c-FLIP and enhancing FasL/Fas-mediated apoptosis pathway显示文摘c-Myc plays an important role in cell proliferation, differentiation, and cell apoptosis. FasL/Fas pathway is a key regulator of cell apoptosis. This study was aimed to investigate the effects of c-Myc on the FasL/Fas pathway in ischemia-reperfusion (I/R)-induced renal injury. Rats were objected to bilateral renal ischemia for 60 min and reperfused for 24 or 48 h. NRK-52E cells were treated with hypoxia-reoxygenation (H/R) or FasL. Immunohistochemistry was used to identify the distribution of c-Myc. Cell apoptosis was assessed by TUNEL staining. Ad-c-Myc and recombinant pcDAN 3.0 were used to overexpress c-Myc and c-FLIP, respectively. ChIP assay and luciferase assay were used to detect the binding of c-Myc to c-FLIP promoter. In I/R rats, c-Myc was increased signi?cantly and mainly located in renal tubular epithelial cells;meanwhile, c-FLIP was decreased, cleaved caspase-8, cleaved caspase-3 and TUNEL-positive staining cells were increased. Treatment of I/R rats with c-Myc inhibitor 10058-F4 signi?cantly attenuated the decrease in c-FLIP, the increase in cleaved caspase-8, cleaved caspase-3, TUNEL-positive cells, Scr and BUN in I/R rats. In NRK-52E cells, hypoxia and reoxygen induced the increase in c-Myc and decrease in c-FLIP. ChIP and luciferase assay results indicated that c-Myc binds to the promoter region of c-FLIP gene. Overexpression of c-Myc markedly decreased c-FLIP. Overexpression of c-FLIP inhibited the increase in cleaved caspase-8 and caspase-3 induced by FasL. Data indicated that c-Myc is increased in kidneys of I/R rats and negatively regulates the expression of c-FLIP, then enhanced FasL-induced cell apoptosis in I/R stress. | Dan Xu Bao Wang Pan-pan Chen Yan-zhe Wang Nai-jun Miao Fan Yin Qian Cheng Zhuan-li Zhou Hong-yan Xie Li Zhou Jun Liu Xiao-xia Wang Hong Xue Wei Zhang Li-min Lu | 2019 | Acta Pharmacologica Sinica2019，40，8： | 4 |
| 11 | Effects of kanglaite capsules combined with transcatheter arterial chemoembolization (TACE) on patients with mid or late-stage primary hepatocellular carcinoma (HCC)显示文摘观察囊与 transcatheter 相结合的 kanglaite (KLT ) 的临床的效果的目的动脉的 chemoembolization (不作声) 在与中间或迟了阶段的主要肝细胞癌(HCC ) 对待病人。65 个盒子随机被划分成 2 个组,的方法在联合组的 32 个病人接受了 KLT 囊 + 的治疗不作声,在控制组的 33 个病人被对待与独自不作声。客观反应率(RR ) ,浆液高山哈 fetoprotein (法新社) ,外部血 T 淋巴细胞亚群(T-LS ) ,生命(QOL ) 的质量,前进(TTP ) 的时间和不利反应在 2 之间被遵守并且比较组。客观反应评估的结果和浆液高山哈 fetoprotein 层次没有在二个组之间的有效差量(P >
0.05 ) 。联合组是优异的在生命(QOL ) 的质量控制组,前进(TTP ) 的时间,外部血 T 淋巴细胞亚群(CD3+ , CD4+ , CD4+∖CD8 比率) 并且肝不利反应,与有效差量(P <
0.05 ) 。结论 KLT 囊与结合了不作声是到对待的一个有效方法失去了外科的治疗的机会的主要肝细胞癌(HCC ) 病人。 | Daojun Li Xinhua Xu Dan Bao Feng Xue Delan Dai | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，2： | 4 |
| 12 | Single Nucleotide Polymorphism of FSHβ Gene Associated with Reproductive Traits in Japanese Flounder (Paralichthys olivaceus)显示文摘Follicle stimulating hormone β (FSHβ) of Japanese flounder (Paralichthys olivaceus) plays a key role in the regulation of gonadal development.This study aimed to investigate molecular genetic characteristics of the FSHβ gene and elucidate the effects of single nucleotide polymorphisms (SNPs) of FSHβ on reproductive traits in Japanese flounder.We used polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) and sequencing of the FSHβ gene in 60 individuals.We identified only an SNP (T/C) in the coding region of exon3 of FSHβ.The SNP (T/C) did not lead to amino acid changes at the position 340 bp of FSHβ gene.Statistical analysis showed that the SNP was significantly associated with testosterone (T) level and gonadosomatic index (GSI) (P<0.05).Individuals with genotype TC of the SNP had significantly higher serum T levels and GSI (P<0.05) than that of genotype CC.Therefore, FSHβ gene could be a useful molecular marker in selection for prominent reproductive trait in Japanese Flounder. | HE Feng WEN Haishen YU Dahui LI Jifang SHI Bao CHEN Caifang ZHANG Jiaren JIN Guoxiong CHEN Xiaoyan Shi Dan Yang Yanping | 2010 | Journal of Ocean University of China2010，9，4： | 4 |
| 13 | Establishment of a new acute-on-chronic liver failure model显示文摘To establish an animal model of acute-on-chronic liver failure(ACLF) that would replicate the pathological process of ACLF in humans, rats were administered porcine serum(PS) for 11 weeks. Liver fibrosis was determined by pathological and biochemical assessments. The animals then were injected with D-galactosamine(D-gal) and lipopolysaccharide(LPS). The survival times of animals with cirrhosis and ACLF were determined over 48 h. Other animals were killed at 0, 4, 8 and 12 h after administration of D-gal/LPS. Liver injury was assessed by histopathological analysis and biochemical indices, and apoptosis was detected by Western blot and TUNEL analysis. After PS administration for 11 weeks the serum levels of hyaluronic acid and N-procollagen type III peptide increased significantly, and serious fibrosis and cirrhosis was observed at weeks 10 and 11. Cirrhotic rats were injected with D-gal/LPS to induced ACLF; the rate of mortality over 48 h was 80%. ALT and AST levels increased markedly at 4 h, but decreased significantly at8 and 12 h post-treatment. The total bilirubin, direct bilirubin, and total bile acids levels increased markedly at 8 and 12 h. Clotting times, TNF-α and IL-6 levels increased significantly, except for 12 h post-treatment.Apoptosis, inflammation and necrosis were elevated as determined by hematoxylin-eosin staining and TUNEL assays. BCL-2 levels decreased significantly, While BAX levels increased significantly.Cytochrome c expression peaked at 8 h postD-gal/LPS treatment. In conclusion, an ACLF model induced by PS and D-gal/LPS was established and the underlying mechanisms of ACLF development were explored. | Fangfang Li Luyang Miao Hua Sun Yuyang Zhang Xiuqi Bao Dan Zhang | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 4 |
| 14 | SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice显示文摘Background:Cardiovascular diseases(CVDs)and diabetes mellitus(DM)are top two chronic comorbidities that increase the severity and mortality of COVID-19.However,how SARS-CoV-2 alters the progression of chronic diseases remain unclear.Methods:We used adenovirus to deliver h-ACE2 to lung to enable SARS-CoV-2 infection in mice.SARS-CoV-2’s impacts on pathogenesis of chronic diseases were studied through histopathological,virologic and molecular biology analysis.Results:Pre-existing CVDs resulted in viral invasion,ROS elevation and activation of apoptosis pathways contribute myocardial injury during SARS-CoV-2 infection.Viral infection increased fasting blood glucose and reduced insulin response in DM model.Bone mineral density decreased shortly after infection,which associated with impaired PI3K/AKT/mTOR signaling.Conclusion:We established mouse models mimicked the complex pathological symptoms of COVID-19 patients with chronic diseases.Pre-existing diseases could impair the inflammatory responses to SARS-CoV-2 infection,which further aggravated the pre-existing diseases.This work provided valuable information to better understand the interplay between the primary diseases and SARS-CoV-2 infection. | Yuanwu Ma Dan Lu Linlin Bao Yajin Qu Jiangning Liu Xiaolong Qi Lei Yu Xu Zhang Feifei Qi Qi Lv Yunpeng Liu Xudong Shi Caixian Sun Jing Li Jie Wang Yunlin Han Kai Gao Wei Dong Ning Liu Shan Gao Jing Xue Qiang Wei Sidan Pan Hong Gao Lianfeng Zhang Chuan Qin | 2021 | Animal Models and Experimental Medicine2021，4，1： | 3 |
| 15 | Impact of Enterprise Ownership and Size on Registered Hematotoxicity in Benzene-exposed Workers显示文摘Benzene is a classified as a human carcinogen that can cause myelodysplastic syndrome and acute myelogenous leukemia[1]. This compound is also a potent toxin suppressing the bone marrow. Accordingly, benzene causes serious hematological adverse effects, such as pancytopenia and aplastic anemia. In the 1920s, the carcinogenicity of benzene was identified in humans, in which it was shown to cause acute myelocytic leukemia (AML)[2]. The reports highlighting the first cases of hematopoietic disease associated with benzene appeared in China in the late 1950s[3]. Moreover, benzene exposure is likely to result in AML, having been identified as a Group Ⅰ carcinogen by the International Agency for Research on Cancer (1987)[4]. A meta-analysis has determined the links existing between childhood leukemia and the numbers of latent benzene exposure metrics[5]. | WANG Bo Shen HAN Lei YANG Dan Dan ZHANG Juan YIN Li Hong ZHANG Meng Ying XU Kai XING Cai Hong ZHU Bao Li PU Yue Pu | 2018 | Biomedical and Environmental Sciences2018，31，12： | 3 |
| 16 | Gut microbiota mediates the absorption of FLZ,a new drug for Parkinson’s disease treatment显示文摘The gut microbiota plays an important role in regulating the pharmacokinetics and pharmacodynamics of many drugs.FLZ,a novel squamosamide derivative,has been shown to have neuroprotective effects on experimental Parkinson’s disease(PD)models.FLZ is under phase I clinical trial now,while the underlying mechanisms contributing to the absorption of FLZ are still not fully elucidated.Due to the main metabolite of FLZ was abundant in feces but rare in urine and bile of mice,we focused on the gut microbiota to address how FLZ was metabolized and absorbed.In vitro studies revealed that FLZ could be exclusively metabolized to its major metabolite M1 by the lanosterol 14 alpha-demethylase(CYP51)in the gut microbiota,but was almost not metabolized by any other metabolism-related organs,such as liver,kidney,and small intestine.M1 was quickly absorbed into the blood and then remethylated to FLZ by catechol O-methyltransferase(COMT).Notably,dysbacteriosis reduced the therapeutic efficacy of FLZ on the PD mouse model by inhibiting its absorption.The results show that the gut microbiota mediate the absorption of FLZ through a FLZ-M1-FLZ circulation.Our research elucidates the vital role of the gut microbiota in the absorption of FLZ and provides a theoretical basis for clinical pharmacokinetic studies and clinical application of FLZ in the treatment of PD. | Junmei Shang Shurong Ma Caixia Zang Xiuqi Bao Yan Wang Dan Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 3 |
| 17 | Effect of Eurycoma longifolia stem extract on uric acid excretion in hyperuricemia mice显示文摘OBJECTIVE Eurycoma longifolia is a tropical medicinal plant belonging to Simaroubaceae distributed in South East Asia.The aim of this study is to explore the effect and mechanism of E.longifolia stem 70%ethanol extract(EL)and its active com⁃poundson uric acid excretion.METHODS Potassium oxonate(PO)induced hyperuricemia rats and adenine-PO induced hyperuricemia mouse model were used to evaluate the effects of EL.Ultra Performance Liquid Chromatography was used to determine the levels of plasma or serum uric acid and creatinine.Hematoxylin-eosin staining was applied to observe kidney pathological changes,Western blot⁃ting was applied to detect protein expression levels of uric acid transporters.Effects of constituents on urate uptake were tested in hU⁃RAT1-expressing HEK293T cells.RESULTS EL significantly reduced serum and plasma uric acid levels at dosages of 100,200 and 400 mg·kg^-1 in hyperuricemia rats and mice,and increased the clearance rate of uric acid and creatinine,improved therenal pathological injury.The protein expression levels of urate reabsorption transporter 1(URAT1)and glucose transporter 9 were down-regulated while sodium-dependent phosphate transporter 1 and ATP-binding cassette transporter G2 were up-regulated in the kidney after EL treat⁃ment.The diterpenes(50μmol·L^-1)isolated from EL showed inhibitory effects on urate uptake in hURAT1-expressing HEK293T cells,and the effect of eurycomanol was further confirmed in vivo.CONCLUSION EL significantly reduced blood uric acid levels and prevented pathological changes of kidney in PO induced hyperuricemia animal model,improved renal urate transports.We partly clarified the mechanism was related to suppressing effect of URAT1 by diterpene in EL.This study is the first to demonstrate that EL plays a role in hyperuricemia by promoting renal uric acid excretion. | BAO Rui-xia LIU Meng-yang WANG Dan WEN Shao-shi YU Hai-yang ZHONG Yi LI Zheng ZHANG Yi WANG Tao | 2019 | 中国药理学与毒理学杂志2019，33，9： | 3 |
| 18 | EAST-Educational Adaptive-optics Solar Telescope显示文摘For the public having a better understanding of solar activities,the Educational Adaptive-optics Solar Telescope(EAST)was built in July 2021 and is located at the Shanghai Astronomy Museum.The EAST consists of a 65 cm aperture solar telescope with a 177-element adaptive optics system and two-channel high resolution imaging system at the Hαand TiO bands,in addition to three full disk solar telescopes at CaK,Hαand TiO bands equipped on the tube of the main telescope.In this paper,the configuration of the EAST is described.Its performance and on-sky observational results are presented.The EAST,to our knowledge,is the most advanced solar telescope for the popularization of science in the world.Due to its excellent performance,the data acquired by the EAST can also be used for research on solar physics and space weather prediction. | Changhui Rao Xuejun Rao Zhimao Du Hua Bao Cheng Li Jinlong Huang Youming Guo Libo Zhong Qing Lin Xin Ge Jinsheng Yang Xinlong Fan Yangyi Liu Dan Jia Xin Li Mei Li Ming Zhang Yuntao Cheng Jiahui Zhou Jiawen Yao Lanqiang Zhang Naiting Gu | 2022 | Research in Astronomy and Astrophysics2022，22，6： | 3 |
| 19 | Improving the Extreme Rainfall Forecast of Typhoon Morakot(2009) by Assimilating Radar Data from Taiwan Island and China's Mainland显示文摘This study examined the impact of an improved initial field through assimilating ground-based radar data from China's Mainland and Taiwan Island to simulate the long-lasting and extreme rainfall caused by Morakot(2009). The vortex location and the subsequent track analyzed through the radial velocity data assimilation(VDA) are generally consistent with the best track. The initial humidity within the radar detecting region and Morakot's northward translation speed can be significantly improved by the radar reflectivity data assimilation(ZDA). As a result, the heavy rainfall on both sides of Taiwan Strait can be reproduced with the joint application of VDA and ZDA. Based on sensitivity experiments, it was found that, without ZDA, the simulated storm underwent an unrealistic inward contraction after 12-h integration, due to underestimation of humidity in the global reanalysis, leading to underestimation of rainfall amount and coverage. Without the vortex relocation via VDA, the moister(drier) initial field with(without) ZDA will produce a more southward(northward) track, so that the rainfall location on both sides of Taiwan Strait will be affected. It was further found that the improvement in the humidity field of Morakot is mainly due to assimilation of high-value reflectivity(strong convection) observed by the radars in Taiwan Island, especially at Kenting station. By analysis of parcel trajectories and calculation of water vapor flux divergence, it was also found that the improved typhoon circulation through assimilating radar data can draw more water vapor from the environment during the subsequent simulation, eventually contributing to the extreme rainfall on both sides of Taiwan Strait. | Xuwei BAO Dan WU Xiaotu LEI Leiming MA Dongliang WANG Kun ZHAO Ben Jong-Dao JOU | 2017 | Journal of Meteorological Research2017，31，4： | 3 |
| 20 | Phloroglucinol derivative compound 21 attenuates cuprizoneinduced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation显示文摘Multiple sclerosis(MS) is a chronic autoimmune demyelinating disease in the central nervous system. The myelin loss is mainly caused by dysfunction of oligodendrocytes and inflammatory responses of microglia and astrocytes further aggravate the demyelination. Current therapies for MS focus on suppressing the overactivated immune response but cannot halt the disease progress, so effective drugs are urgently needed. Compound 21 is a phloroglucinol derivative that has been proved to have an outstanding anti-inflammatory effect. The purpose of the present study is to investigate whether this novel compound is effective in MS. The cuprizone-induced model was used in this study to mimic the pathological progress of MS. The results showed that Compound 21 significantly improved the neurological dysfunction and motor coordination impairment. Luxol Fast Blue staining and myelin basic protein immunostaining demonstrated that Compound 21 remarkably promoted remyelination. In addition,Compound 21 significantly promoted oligodendrocytes differentiation. Furthermore, we found that Compound 21 decreased microglia and astrocytes activities and the subsequent neuroinflammatory response, indicating that the anti-inflammatory effect of Compound 21 was also involved in its neuro-protection. All the data prove that Compound 21 exerts protective effect on MS through promoting remyelination and suppressing neuroinflammation, indicating that Compound 21 might be a potential drug candidate for MS treatment. | Zhe Zhao Xiu-qi Bao Zihong Zhang Hui Liu Dan Zhang | 2020 | Science China(Life Sciences)2020，63，6： | 3 |
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