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| 1 | Pathophysiology and biology of peritoneal carcinomatosis显示文摘Peritoneal carcinomatosis represents a devastating form of cancer progression with a very poor prognosis.Its complex pathogenesis is represented by a dynamic process comprising several steps.To the best of our knowledge pathogenesis can be partly explained by 3 major molecular pathways: (1) dissemination from the primary tumor;(2) primary tumor of peritoneum;and (3) independent origins of the primary tumor and peritoneal implants.These are not mutually exclusive and combinations of different mechanisms could occur inside a single case.There are still several aspects which need explanation by future studies.A comprehensive understanding of molecular events involved in peritoneal carcinomatosis is of paramount importance and should be systematically pursued not only to identify novel strategies for the prevention of the condition,but also to obtain therapeutic advances,through the identification of surrogate markers of prognosis and development of future molecular targeted therapies. | Shigeki Kusamura Dario Baratti Nadia Zaffaroni Raffaella Villa Barbara Laterza Maria Rosaria Balestra Marcello Deraco | 2010 | World Journal of Gastrointestinal Oncology2010，2，1： | 8 |
| 2 | Early and long-term postoperative management following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy显示文摘Peritoneal surface malignancies have been traditionally regarded as end-stage conditions amenable to merely palliative options. The combination of aggressive cytoreductive surgery (CRS), involving peritonectomy procedures and multivisceral resections, with intra-operative hyperthermic intra-peritoneal chemotherapy (HIPEC) and/or early postoperative intra-peritoneal chemotherapy (EPIC) to treat the microscopic residual tumor is a new concept. In recent years, promising results have been reported for peritoneal mesothelioma and carcinomatosis of gastrointestinal and gynaecologic origin treated by this combined protocol. However, CRS with HIPEC and/or EPIC is a complex procedure associated with high rates of potentially life-threatening complications. Furthermore, disease progression following comprehensive treatment is not uncommon and represents a relevant cause of treatment failure. The present paper reviews the available information on early postoperative management and long-term follow-up in patients treated with CRS and intraperitoneal chemotherapy. The peculiar clinical and biological alterations that can be expected during an uncomplicated postoperative course, as compared to standard digestive surgery, are discussed. Early recognition and appropriate management of the most common adverse events are addressed, in order to minimize the impact of treatment-related morbidity on survival and quality of life results. Since re-operative surgery with additional HIPEC, has proven to be useful in selected patients with recurrent disease, long-term surveillance aiming at early detection of postoperative disease progression has become a relevant issue. Current results on follow-up investigations are presented. | Dario Baratti Shigeki Kusamura Barbara Laterza Maria Rosaria Balestra Marcello Deraco | 2010 | World Journal of Gastrointestinal Oncology2010，2，1： | 4 |
| 3 | Experience with peritoneal mesothelioma at the Milan National Cancer Institute显示文摘Diffuse malignant peritoneal mesothelioma (DMPM) is an uncommon and rapidly fatal tumor.Therapeutic options have traditionally been limited and ineffective.The biologic and molecular events correlated with poor responsiveness to therapy are still poorly understood.In recent years,an innovative treatment approach involving aggressive cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy has reportedly resulted in improved outcome,as compared to historical controls.Since 1995,at the National Cancer Institute (NCI) of Milan (Italy),patients with DMPM have been treated with CRS and hyperthermic intraperitoneal chemotherapy (HIPEC).In the present paper,clinical experiences and basic science investigations on DMPM at Milan NCI are reviewed.Perioperative and long-term outcome results with CRS and HIPEC are presented.Clinico-pathological prognostic factors were investigated by multivariate analysis.The pathologic features and immunohistochemical markers related to DMPM biologic behavior were assessed in a large case-series uniformly treated at our institution.The prevalence and prognostic role of telomere maintenance mechanisms,which account for the limitless cell replicative potential of many malignancies,were studied.The dysregulation of the apoptotic pathways may play a role in the relative chemo-resistance of DMPM and a better understanding of apoptosis-related mechanisms could result in novel targeted therapeutic strategies.On this basis,the expression of survivin and other IAP family members (IAP-1,IAP-2,and X-IAP),the pro-apoptotic protein Smac/DIABLO,and antigens associated with cell proliferation (Ki-67) and apoptosis (caspase-cleaved cytokeratin-18) were analyzed.Finally,analyses of EGFR,PDGFRA and PDGFRB were performed to ascertain if deregulation of RTK could offer useful alternative therapeutic targets. | Marcello Deraco Dario Baratti Antonello Domenico Cabras Nadia Zaffaroni Federica Perrone Raffaella Villa Jenny Jocollè Maria Rosaria Balestra Shigeki Kusamura Barbara Laterza Silvana Pilotti | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 3 |
| 4 | Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates显示文摘 | Calio R N Villani E Balestra F | 1994 | Antivir Res1994，23，1： | 1 |
| 5 | Effects of esomeprazole on glutathione levels and mitochondrial oxidative phosphorylation in the gastric mucosa of rats treated with indomethacin显示文摘 | O. Pastoris M. Verri F. Boschi O. Kastsiuchenka B. Balestra F. Pace M. Tonini G. Natale | 2008 | Naunyn-Schmiedeberg’s Archives of Pharmacology2008，，4： | 1 |
| 6 | Aging society, health and the environment显示文摘 | Carlotta Balestra Davide Dottori | 2012 | Journal of Population Economics2012，，3： | 1 |
| 7 | A critical review of physiological bubble formation in hyperbaric decompression显示文摘 | Papadopoulou V Eckersley RJ Balestra C | 2013 | Adv Colloid Interface Sci2013，19，： | 1 |
| 8 | Functional and neurochemical changes of the gastrointestinal tract in a rodent model of Parkinson’s disease显示文摘 | Blandini F Balestra B Levandis G | 2009 | Neurosci Letters2009，467，3： | 1 |
| 9 | Efficacy of cancer chemotherapy in relation to synchronization of cortisol rhythm, immune status and psychospiritual profile in metastatic non-small cell lung cancer显示文摘 | Lissoni P Messina G Balestra A | 2008 | In Vivo2008，22，： | 1 |
| 10 | Double-gate silicon-on-insulator transistor with volume inversion:a new device with greatly enhanced performances显示文摘 | Balestra F Cristoloveanu S Benachir M | 1987 | IEEE Elec Dev Lett1987，8，3： | 1 |
| 11 | Time-frequency analysis of surface myoelectric signals during athletic movement显示文摘 | Balestra C Frassinelli S | 2001 | IEEE Engineering in Medicine and Biology Magazine2001，20，6： | 1 |
| 12 | Pelvic recurrence of rectal cancer:our experience显示文摘 | Di Bartolomeo N Balestra M R Liddo G | 2005 | Suppl Tumori2005，4，3： | 1 |
| 13 | Antibodies against neuronal nicotinic receptor subtypes in neurological disorder 显示文摘 | Balestra B Moretti M Longhi R | 2002 | J Neuroimmunol2002，102，1： | 1 |
| 14 | Pooling Cross-Section and Time-Series Data in the Estimation of a Dynamic Economic Model: The Demand for Natural Gas 显示文摘 | Balestra P M Nerlove | 1966 | Econometric1966，，34： | 1 |
| 15 | Effect of the Gelation Process on the Production of Alginate Microbeads by Microfluidic Chip Technology显示文摘 | Capretto L Mazzitelli S Balestra C | 2008 | Lab on a Chip2008，8，： | 1 |
| 16 | Microcirculation and mitochondria in sepsis: getting out of breath 显示文摘 | Balestra GM Legrand M Ince C | 2009 | Curr Opin Anaesthesiol2009，22，2： | 1 |
| 17 | Time-frequency analysis of surface myoelectric sig- nals duringathletic movement 显示文摘 | Balestra G Frassinelli S Knaflitz M Molinari F | 2001 | IEEE Engineer- ing in Medicine and Biology Magazine2001，20，6： | 1 |
| 18 | Autogenous platelet-rich plasma in combination with bovine-derived hydroxyapatite xenograft for treatmenl of a cystic lesion of the jaw显示文摘 | BELLI E LONGO B BALESTRA F M | 2005 | J Craniofac Surg2005，16，6： | 1 |
| 19 | Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors 显示文摘 | Qian X Balestra ME Yamanaka S | 1998 | At-terioscler Thromb Vasc Biol1998，18，6： | 1 |
| 20 | Pelvic recurrence of rectal cancer: our experience 显示文摘 | Di Bartolomeo N Balestra MR Liddo G | 2005 | Suppl Tumori2005，4，： | 1 |
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