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| 1 | Semaglutide降低2型糖尿病患者的心脑血管事件风险显示文摘心血管疾病是2型糖尿病患者发生并发症和死亡的主要原因。最近的一些临床试验报告,一种钠-葡萄糖协同转运蛋白-2抑制剂(依帕列净)和一种胰高血糖素样肽-1(GLP-1)类似物(利拉鲁肽),能够改善心血管高风险的2型糖尿病患者的心血管结局。Semaglutide是GLP-1的一种类似物,半衰期长达约1周,可以一周一次皮下注射,但是尚不清楚其对2型糖尿病患者的心血管效应;由于Semaglutide目前处于开发阶段,尚未被批准用于治疗2型糖尿病。 | Marso SP Bain SC Consoli A 王建中 | 2016 | 中华肾病研究电子杂志2016，5，5： | 141 |
| 2 | Model for end-stage liver disease score versus Child score in predicting the outcome of surgical procedures in patients with cirrhosis显示文摘AIM:To determine factors affecting the outcome of patients with cirrhosis undergoing surgery and to compare the capacities of the Child-Turcotte-Pugh(CTP) and model for end-stage liver disease(MELD)score to predict that outcome. METHODS:We reviewed the charts of 195 patients with cirrhosis who underwent surgery at two teaching hospitals over a five-year period.The combined endpoint of death or hepatic decompensation was considered to be the primary endpoint. RESULTS:Patients who reached the endpoint had a higher MELD score,a higher CTP score and were more likely to have undergone an urgent procedure.Among patients undergoing elective surgical procedures,no statistically significant difference was noted in the mean MELD(12.8±3.9 vs 12.6±4.7,P=0.9)or in the mean CTP(7.6±1.2 vs 7.7±1.7,P=0.8)between patients who reached the endpoint and those who did not.Both mean scores were higher in the patients reaching the endpoint in the case of urgent procedures(MELD:22.4± 8.7 vs 15.2±6.4,P=0.0007;CTP:9.9±1.8 vs 8.5±1.8, P=0.008).The performances of the MELD and CTP scores in predicting the outcome of urgent surgery were only fair,without a significant difference between them (AUC=0.755±0.066 for MELD vs AUC=0.696±0.070 for CTP,P=0.3). CONCLUSION:The CTP and MELD scores performedequally,but only fairly in predicting the outcome of urgent surgical procedures.Larger studies are needed to better define the factors capable of predicting the outcome of elective surgical procedures in patients with cirrhosis. | Maarouf A Hoteit Amaar H Ghazale Andrew J Bain Eli S Rosenberg Kirk A Easley Frank A Anania Robin E Rutherford | 2008 | World Journal of Gastroenterology2008，14，11： | 16 |
| 3 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 4 | Human host defence peptide LL -37 prevents bacterial biofilm formation 显示文摘 | OVERHAGE J CAMPISANO A BAINS M | 2008 | hd''eet Immun2008，76，9： | 1 |
| 5 | Cardiac device im plantation in the United States from 1997 through 2004:a pop- ulation-based analysis显示文摘 | Zhan C Baine WB Sedrakyan A | 2008 | J Gen Intern Med2008，23，1： | 1 |
| 6 | A ret- rospective review assessing the efficacy and safety of nitrofurantoin in renal impairment 显示文摘 | Bains A Buna D Hoag NA | 2009 | Can Pharm J2009，142，5： | 1 |
| 7 | Construction of a whole-cell gene reporter for the fluorescent bioassay of nitrate 显示文摘 | Taylor C J Bain L A Richardson D J | 2004 | Anal Biochem2004，328，1： | 1 |
| 8 | Construction of a whole-cell gene reporter for the fluorescent bioassay of nitrate显示文摘 | Taylor C J Bain L A Richardson DJ | 2004 | Anal Biochem2004，328，1： | 1 |
| 9 | Decreased thin filament density and length in human atrophic soleus muscle fibers after spaceflight显示文摘 | Riley D A Bain J L Thompson J L | 2000 | J Appl Physiol2000，88，2： | 1 |
| 10 | Establishment of primary and continuous cultures of epithelial cells from larval lepidopteran midguts显示文摘 | Baines D Brownwright A Schwartz J L | 1994 | Insect Phyiol1994，40，4： | 1 |
| 11 | Variations in weathering processes and rates with time in a chronosequence of soils from Glen Feshie, Scotland显示文摘 | Bain D C Mellor A Robertson-Rintoul M S E | 1993 | Geoderma1993，57，： | 1 |
| 12 | FLT3 and NPM1 mutations in myelodysplastic syndromes,Frequency and potential value for predicting progression to acute myeloid leukemia显示文摘 | Bains A Luthra R Medeiros LJ | | 0，，： | 1 |
| 13 | Foreign-body aspira- tion in the adult:presentation and management显示文摘 | Bain A Barthos A Hoffstein V | 2013 | Can Respir J2013，20，： | 1 |
| 14 | Spectrin and ankyrin-based path- ways: metazoan inventions for integrating cells into tissues 显示文摘 | BENNETT V BAINES A J | 2001 | Physiological Reviews2001，81，3： | 1 |
| 15 | Diamagnetic corrections and pascal's constants显示文摘 | BAIN G A BERRY J F | | 0，，04： | 1 |
| 16 | Glutamine reduces bacterial translation after small bowl transplantation in cyclosporing treated rat显示文摘 | Zhang W Frnkel W L Bain A | 1995 | J Surg Res1995，58，2： | 1 |
| 17 | Variation in antibiotic inhibitory abilities among streptomycetes from south Texas agrieultural soils显示文摘 | Blaneo E M Little C R Baines A L D | 2007 | Soil Biology & Biochemistry2007，39，： | 1 |
| 18 | Aquatic ecosystem protection and restoration:advances in methods for assessment and evaluation显示文摘 | Bain M B Harig A L Loucks D P | 2000 | Environmental Science & Policy2000，，3： | 1 |
| 19 | Current status of molecular markers for early detection of sporadic pancreatic cancer 显示文摘 | CHAKRABORTY S BAINE M J SASSON A R | 2011 | Biochem Biophys Acta2011，1815，1： | 1 |
| 20 | Breast reconstruc- tion显示文摘 | Ahmed S Snelling A Bains M | 2005 | BMJ2005，330，23： | 1 |
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