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| 1 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 2 | Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats显示文摘AIM:To investigate oxidative stress(OS)-mediated damage and the behavior of extracellular matrices in various rat models because shear stress with portal hypertension and cold ischemia/warm reperfusion injury trigger the liver regeneration cascade after surgery. These injuries also cause fatal liver damage.METHODS: Rats were divided into four groups according to the surgery performed: control; hepatectomy with 40% liver remnant(60% hepatectomy); orthotopic liver transplantation(OLT) with whole liver graft(100% OLT); and split OLT(SOLT) with 40% graft(40% SOLT). Survival was evaluated. Blood and liver samples were collected at 6 h after surgery. Biochemical and histopathological examinations were performed. OSinduced damage, 4-hydroxynonenal, ataxia-telangiectasia mutated kinase, histone H2AX, phosphatidylinositol 3-kinase(PI3K) and Akt were evaluated by western blotting. Behavior of extracellular matrices, matrix metalloproteinase(MMP)-9, MMP-2, tissue inhibitor of metalloproteinase(TIMP)-1 and TIMP-2 were also evaluated by western blotting and zymography. RESULTS: Although 100% OLT survived, 60% hepatectomy and 40% SOLT showed poor survival. Histopathological, immunohistological, biochemical and protein assays revealed that 60% hepatectomy, 100% OLT and 40% SOLT showed liver damage. PI3K and Akt were decreased in 60% hepatectomy and 40% SOLT. For protein expression, 40% SOLT showed differences in MMP-9, MMP-2 and TIMP-2. TIMP-1 showed differences in 60% hepatectomy and 40% SOLT. For protein activity, MMP-9 demonstrated significant differences in 60% hepatectomy, 100% OLT and 40% SOLT. CONCLUSION: Under conditions with an insufficient liver remnant, prevention of OS-induced damage via the Akt/PI3K pathway may be key to improve the postoperative course. MMP-9 may be also a therapeutic target after surgery. | Tomohide Hori Shinji Uemoto Feng Chen Lindsay B Gardner Ann-Marie T Baine Toshiyuki Hata Takayuki Kogure Justin H Nguyen | 2014 | World Journal of Hepatology2014，6，2： | 7 |
| 3 | Simple and reproducible hepatectomy in the mouse using the clip technique显示文摘AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data. | Tomohide Hori Norifumi Ohashi Feng Chen Ann-Marie T Baine Lindsay B Gardner Toshiyuki Hata Shinji Uemoto Justin H Nguyen | 2012 | World Journal of Gastroenterology2012，18，22： | 4 |
| 4 | Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction显示文摘 | Bain G Mtlller T Wang X | 2003 | Bio- chem Biophys Res Commun2003，301，1： | 1 |
| 5 | Changes in atherosclerotic plaquesinduced by inhalation of diesel exhaust 显示文摘 | BAIN KIDO T SUZUKI H | 2011 | Atherosclerosis2011，216，2： | 1 |
| 6 | An arginine ladder in OprP mediates phosphate-specific transfer across the outer membrane显示文摘 | Moraes T F Bains M Hancock R g | 2007 | Nat Struct Mol Biol2007，14，1： | 1 |
| 7 | Clinical-practice recom- mendations for the management of bowel obstruction in patients with end-stage cancer 显示文摘 | Ripamonti C Twycross T Baines M | 2001 | Support Care Cancer2001，9，： | 1 |
| 8 | Canadian National Breast Screening Study-2:13-year results of a randomized trial in women aged 50-59 years显示文摘 | Miller AB To T Baines CJ | | 0，，18： | 1 |
| 9 | Regulation of epithelial cell mi- gration and tumor formation by beta - catenin signaling 显示文摘 | Muller T Bain G Wang X | 2002 | Exp Cell Rer2002，280，1： | 1 |
| 10 | The Canadian National Breast Screening Study-1:breast cancer mortality after 11 to 16 yeara of follow-up:a randomized screening trial of mammograpby in women age 40 to 49 years显示文摘 | Miller AB To T Baines CJ | | 0，，5： | 1 |
| 11 | Cell biology of ischemia/ reperfusion injury显示文摘 | Kaloqeris T Baines CP Krenz M | 2012 | Int Rev Cell Mol Biol2012，298，： | 1 |
| 12 | Randomised trial of interferon a2b plus ribavirin for 48 weeks or for 24 weeks versus interferon a2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus显示文摘 | Poynard T Mareellln P Lee SS Minuk GS Ideo G Bain V Heathcote J Zeuzem S Trepo C Albrecht J | | 0，，： | 1 |
| 13 | State-of-the-art in product-service systems 显示文摘 | Baines T S Lightfoot H W Evans S | 2007 | Journal of Engineering Manufacture2007，221，10： | 1 |
| 14 | Activated beta-eatenin inducesosteoblast differentiation of C3H10 T1/2 cells and participates in BMP2 mediated signal transduction 显示文摘 | Bain G Mailer T Wang X | 2003 | Biochem Biophys Res Commun2003，301，1： | 1 |
| 15 | Humans:the missing link in manufacturing simulation显示文摘 | BAINES T MASON S SIEBERS P | 2004 | Simulation Modelling Practice and Theory2004，12，3： | 1 |
| 16 | Adsorption of thiocyanate on polyerystalline silver and gold electrodes studied in situ by sum-frequency spectroscopy显示文摘 | Ong T H Davies P B Bain C D | 1993 | The Journal of Physical Chemistry1993，97，12： | 1 |
| 17 | Cell biology of ischemia reperfusion injury显示文摘 | KAIOGERIS T BAINES C P KRENZM et a1 | 2012 | Int Rev Cell Mol Biol2012，298，： | 1 |
| 18 | Formation of monolayer films by the spontaneous assembly of organic thiols from solution onto gold显示文摘 | BAIN C D TROUGHTON E B TAO Y T | 1989 | J Am Chem Soe1989，111，1： | 1 |
| 19 | Genetics of fertility restoring of‘wild abortive’cytoplasmic male sterility in rice (Oryza sativa L)显示文摘 | Bharaj T S Bains S S Gagneja M R | 1991 | Euphytica1991，56，： | 1 |
| 20 | Activated beta - eatenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction显示文摘 | Bain G Mtiller T Wang X | 2003 | Bio- chem Biophys Res Commun2003，301，1： | 1 |
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