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| 1 | Hepatitis B virus molecular biology and pathogenesis显示文摘As obligate intracellular parasites,viruses need a host cell to provide a milieu favorable to viral replication.Consequently,viruses often adopt mechanisms to subvert host cellular signaling processes.While beneficial for the viral replication cycle,virus-induced deregulation of host cellular signaling processes can be detrimental to host cell physiology and can lead to virus-associated pathogenesis,including,for oncogenic viruses,cell transformation and cancer progression.Included among these oncogenic viruses is the hepatitis B virus(HBV).Despite the availability of an HBV vaccine,350-500 million people worldwide are chronically infected with HBV,and a significant number of these chronically infected individuals will develop hepatocellular carcinoma(HCC).Epidemiological studies indicate that chronic infection with HBV is the leading risk factor for the development of HCC.Globally,HCC is the second highest cause of cancer-associated deaths,underscoring the need for understanding mechanisms that regulate HBV replication and the development of HBV-associated HCC.HBV is the prototype member of the Hepadnaviridae family;members of this family of viruses have a narrow host range and predominately infect hepatocytes in their respective hosts.The extremely small and compact hepadnaviral genome,the unique arrangement of open reading frames,and a replication strategy utilizing reverse transcription of an RNA intermediate to generate the DNA genome are distinguishing features of the Hepadnaviridae.In this review,the authors provide a comprehensive description of HBV biology,summarize the model systems used for studying HBV infections,and highlight potential mechanisms that link a chronic HBV-infection to the development of HCC.For example,the HBV X protein(HBx),a key regulatory HBV protein that is important for HBV replication,is thought to play a cofactor role in the development of HBV-induced HCC,and the authors highlight the functions of HBx that may contribute to the development of HBV-associated HCC. | R.Jason Lamontagne Sumedha Bagga Michael J.Bouchard | 2016 | Hepatoma Research2016，2，1： | 19 |
| 2 | Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy显示文摘Colorectal cancer(CRC)is a predominant life-threatening cancer,with liver and peritoneal metastases as the primary causes of death.Intestinal inflammation,a known CRC risk factor,nurtures a local inflammatory environment enriched with tumor cells,endothelial cells,immune cells,cancer-associated fibroblasts,immunosuppressive cells,and secretory growth factors.The complex interactions of aberrantly expressed cytokines,chemokines,growth factors,and matrix-remodeling enzymes promote CRC pathogenesis and evoke systemic responses that affect disease outcomes.Mounting evidence suggests that these cytokines and chemokines play a role in the progression of CRC through immunosuppression and modulation of the tumor microenvironment,which is partly achieved by the recruitment of immunosuppressive cells.These cells impart features such as cancer stem cell-like properties,drug resistance,invasion,and formation of the premetastatic niche in distant organs,promoting metastasis and aggressive CRC growth.A deeper understanding of the cytokineand chemokine-mediated signaling networks that link tumor progression and metastasis will provide insights into the mechanistic details of disease aggressiveness and facilitate the development of novel therapeutics for CRC.Here,we summarized the current knowledge of cytokine-and chemokine-mediated crosstalk in the inflammatory tumor microenvironment,which drives immunosuppression,resistance to therapeutics,and metastasis during CRC progression.We also outlined the potential of this crosstalk as a novel therapeutic target for CRC.The major cytokine/chemokine pathways involved in cancer immunotherapy are also discussed in this review. | Ajaz A.Bhat Sabah Nisar Mayank Singh Bazella Ashraf Tariq Masoodi Chandra P.Prasad Atul Sharma Selma Maacha Thasni Karedath Sheema Hashem Syed Besina Yasin Puneet Bagga Ravinder Reddy Michael P.Frennaux Shahab Uddin Punita Dhawan Mohammad Haris Muzafar A.Macha | 2022 | Cancer Communications2022，42，8： | 8 |
| 3 | Nephrotic Syndrome显示文摘 | Aditi Sinha Arvind Bagga | 2012 | The Indian Journal of Pediatrics2012，，8： | 2 |
| 4 | Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee显示文摘 | Bagga H Burkhardt D Sambrook P | | Journal of Rheumatology0，，： | 2 |
| 5 | Nephrotic syndrome in children显示文摘 | Bagga A Mantan M | 2005 | Indian J Med Res2005，122，1： | 1 |
| 6 | Enalapril dosage in steroid-resistant nephrotic syndrome显示文摘 | Bagga A Mudgoudar BD Hari P | 2004 | Pediatr Nephrol2004，19，1： | 1 |
| 7 | Two-machine flowshop with separated sequence-independent setup times:Mean completion time criterion显示文摘 | Bagga P C Khurana K | 1986 | Indian Journal of Management and Systems1986，2，： | 1 |
| 8 | Evalua- tion of iron chemical coagulation and electrocoagulation pretreatment for sur- face water microfiltration 显示文摘 | Bagga A Chellam S Clifford D | 2008 | J Membr Sci2008，309，12： | 1 |
| 9 | Short-term efficacy of rituximab versus tacrolimus in steroid-dependent nephrotic syndrome 显示文摘 | Sinha A Bagga A Gulati A | 2012 | Pedi- atr Nephrol2012，27，2： | 1 |
| 10 | Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation显示文摘 | Bagga S Bracht J Hunter S | 2005 | Cell2005，122，4： | 1 |
| 11 | Risk factors for early onset severe pre-eclampsia and eclampsia among north Indian women显示文摘 | Nanjundan P Bagga R Kalra J K | 2011 | Journal of Obstetrics and Gynaecology2011，31，5： | 1 |
| 12 | Assessment of lexical semantic judgment abilities in alcohol-dependent subjects: an fMRI study显示文摘 | Bagga D Singh N Modi S | 2013 | J Biosci2013，38，5： | 1 |
| 13 | Mycophenolate Mofetil and Prednisonlone Therapy in Children with Steroid-depedent tephrotic syndrome显示文摘 | BAGGA A HARI P MOUDGIL A | 2003 | Am J kidney Dis2003，42，6： | 1 |
| 14 | Peripheral gangrene in children with atypical hemolytic uremic syndrome 显示文摘 | Malina M Gulati A Bagga A | 2013 | Pediat- rics2013，131，1： | 1 |
| 15 | Preadipocytes stimulate breast cancer cellgrowth显示文摘 | Chamras H1 Bagga D Elstner E | 1998 | Nutr Cancer1998，52，2： | 1 |
| 16 | Evaluation of renal tubular acidosis 显示文摘 | Bagga A Sinha A | 2007 | Indian J Pediatr2007，74，7： | 1 |
| 17 | Adenosarcoma of the uterine cervix with heterologous elements:a case report and review of literature显示文摘 | Bagga R Keepanasseril A Srinivasan R | 2010 | Arch Gynecol Obstet2010，281，4： | 1 |
| 18 | Pure laparoscopic radical nephrectomy with level II vena caval thrombectomy显示文摘 | Romero F R Muntener M Bagga H S | 2006 | Urology2006，68，： | 1 |
| 19 | Behavior problems in nephrotie syndrome 显示文摘 | MEHTA M BAGGA A PANDE P | 1995 | Indian Pediatr1995，32，12： | 1 |
| 20 | Nephrotic syndrome in children显示文摘 | Bagga A Mantan M | 2005 | Indian J Med Res2005，122，1： | 1 |
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