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| 1 | Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes显示文摘In neonates, persistent hyperinsulinemic hypoglycemia (PHH) is associated with nesidioblastosis. In adults, PHH is usually caused by solitary benign insulinomas. We report on an adult patient who suffered from insulin-de- pendent diabetes mellitus, and subsequently developed PHH caused by diffuse nesidioblastosis. Mutations of the MEN1 and Mody 2/3 genes were ruled out. Preoperative diagnostic procedures, the histopathological criteria and the surgical treatment options of adult nesidioblastosis are discussed. So far only one similar case of adult nesidioblastosis subsequent to diabetes mellitus Ⅱ has been reported in the literature. In case of conversion of diabetes into hyperinsulinemic hypoglycemia syndrome, nesidioblastosis in addition to insulinoma should be con- sidered. | A Raffel M Anlauf SB Hosch M Krausch T Henopp J Bauersfeld R Klofat D Bach CF Eisenberger G Klppel WT Knoefel | 2006 | World Journal of Gastroenterology2006，12，44： | 3 |
| 2 | PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation显示文摘AIM:To investigate the in vivo effect of atrial natriureticpeptide(ANP)and its signaling pathway during ortho-topic rat liver transplantation.METHODS:Rats were infused with NaCl,ANP(5 μg/kg),wortmannin(WM,16 μg/kg),or a combination ofboth for 20 min.Livers were stored in UW solution(4°C)for 24 h,transplanted and reperfused.Apoptosis wasexamined by caspase-3 activity and TUNEL staining.Phosphorylation of Akt and Bad was visualized by West-ern blotting and phospho-Akt-localization by confocalmicroscopy.RESULTS:ANP-pretreatment decreased caspase-3activity and TUNEL-positive cells after cold ischemia,indicating antiapoptotic effects of ANP in vivo.The an-tiapoptotic signaling of ANP was most likely caused byphosphorylation of Akt and Bad,since pretreatment withPI 3-kinase inhibitor WM abrogated the ANP-inducedreduction of caspase-3 activity.Interestingly,analysis ofliver tissue by confocal microscopy showed translocationof phosphorylated Akt to the plasma membrane of hepa-tocytes evoked by ANP.CONCLUSION:ANP activates the PI-3-kinase pathwayin the liver in vivo leading to phosphorylation of Bad, an event triggering antiapoptotic signaling cascade inischemic liver. | Uwe Grutzner Melanie Keller Michael Bach Alexandra K Kiemer Herbert Meissner Manfred Bilzer Stefan Zahler Alexander L Gerbes Angelika M Vollmar | 2006 | World Journal of Gastroenterology2006，12，7： | 3 |
| 3 | Expression of Brassica juncea 3-hydroxy-3-methylglutaryl-CoA synthase is developmentally regulated and stress-responsive显示文摘 | Alex D Bach T J Chye M L | 2000 | Plant J2000，22，5： | 1 |
| 4 | Kernel independent component analysis显示文摘 | Jordan M I | 2002 | Journal of Machine Learning Research2002，，3： | 1 |
| 5 | Knockdown of survivin expression by small interfering RNA reduce the clonogenic survival of human sarcoma cell lines independently of P53显示文摘 | Bache M Baterl F | 2004 | Cancer Gene Ther2004，11，3： | 1 |
| 6 | Electrochemical sodium insertion into MnCo oxide显示文摘 | BACH S MILLET M PERIERA-RAMOS J P | 1999 | Electrochemical and Solid-State Letters1999，2，： | 1 |
| 7 | Solid-state dye-sensitized mesoporous TiO2 solar cells with high photon-to-electron conversion efficiencies显示文摘 | Bach U Lupo D Comte P Moser J E Weiss(o)rtel F Salbeck J Spreitzer H Gr(a)tzel M | | 0，，： | 1 |
| 8 | Geochemistry of abyssal peridotites (Mid-Atlantic Ridge, 15° 20' N, ODP Leg 209): implications for fluid/rock interaction in slow spreading environments 显示文摘 | Paulick H Bach W Godard M | 2006 | Chemical Geology2006，234，3： | 1 |
| 9 | Stormwater pollutant runoff: A stochastic approach 显示文摘 | Daly Edoardo Bach Peter M Deletic Aria | 2014 | Advances in Water Resources2014，74，9： | 1 |
| 10 | The IFN gamma receptor: a paradigm for cytokine receptor signaling 显示文摘 | BACH E A AGUET M SCHREIBER R D | 1997 | Annu Rev Immunol1997，15，： | 1 |
| 11 | Hemorrhage into a brain abscess显示文摘 | Bach D Goldenberg M H | 1983 | J Compu Assist Tomogr1983，7，6： | 1 |
| 12 | Oxidation of amines and sulfides with hydrogen peroxide and alkyl hydrogen peroxide, the nature of the oxygen transfer step 显示文摘 | Bach R D Der Su M Schlegel H B | 1994 | Journal of the American Chemical Society1994，116，12： | 1 |
| 13 | Redefining the stormwater first flush phenomenon 显示文摘 | BACH P M MCCARTHY D T DELETIC A | 2010 | Water Research2010，44，8： | 1 |
| 14 | Current evi- dence for transurethral laser therapy of non-muscle in- vasive bladder cancer显示文摘 | Kramer M W Bach T Wolters M | 2011 | World J Urol2011，29，4： | 1 |
| 15 | Easy and rapid method of zygosity determination in transgenic mice by SYBR?Green real-time quantitative PCR with a simple data analysis显示文摘 | HaurognéK Bach J M Lieubeau B | 2007 | Transgenic Res2007，16，1： | 1 |
| 16 | Thermodynamic Con- straints on Hydrogen Generation During Serpentiniza- tion of Ultramafic Roeks显示文摘 | MCCOLLOM T M BACH W | 2009 | Geoehimica et Cosmo- chimica Acta2009，73，3： | 1 |
| 17 | Single-Step and Multistep Mechanisms of Aromatic Nucleophilic Substitution of Halobenzenes and Halonitrobenzenes with Halide Anions: Ab Initio Computational Study Int 显示文摘 | Glukhovtsev M Bach R D Laiter S etal | 1997 | Qrg Chem1997，62，： | 1 |
| 18 | Predictive value of alexithymia: a prospective study in somatizing patients显示文摘 | Bach M Bach D | 1995 | Psychother Psychosom1995，64，： | 1 |
| 19 | Measure of testability as a basis for quality assurance 显示文摘 | Bache R Mullerburg M | 1990 | Software Engineering Journal1990，5，2： | 1 |
| 20 | Solid - state dye - sensitized mesoporous TiO2 solar cells with high photon - to - electron conversion efficiencies显示文摘 | Bach U Lupo D Graetzel M | 1998 | Nature1998，395，6702： | 1 |
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