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| 1 | 根治性手术与短程放疗后行经肛门内镜显微手术(TEM)保留器官治疗早期直肠癌(TREC):一项随机、开放标签的可行性研究显示文摘背景:基于全直肠系膜切除(total mesorectal excision,TME)的根治性手术可能不是早期直肠癌的最佳一线治疗。选择性TME保留器官的策略可以减少治疗的不良反应,又不会显著影响肿瘤结果。该临床随机研究通过与TME比较,探讨器官保留策略的可行性。方法:TREC是一项在英国21个三级转诊中心进行的随机、开放标签的可行性研究。符合条件的受试者年龄≥18岁,分期为T2期或更早,最大直径不超过30 mm;排除淋巴结受累或转移的患者。患者按计算机随机分配(1:1)接受短程放疗保留器官,8~10周后行经肛门内镜显微手术(transanal endo⁃scopic microsurgery,TEM)或TME术。当TEM标本组织病理学特征提示局部复发风险增加时,患者被考虑计划早期转为TME。一项非随机前瞻性登记收集了认为不适合随机化的患者,因为每例患者都是按临床指征治疗的。主要终点为12、18和24个月的累积随机分组。次要结局为应用欧洲癌症研究与治疗组织(EORTC)QLQ C30和CR29量表对意向治疗人群的安全性、有效性和健康相关生活质量进行了评价。该研究已在ISRCTN注册中心注册,ISRCTN14422743。 | 佟伟华 BACH S P GILBERT A BROCK K | 2021 | 结直肠肛门外科2021，27，3： | 9 |
| 2 | PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation显示文摘AIM:To investigate the in vivo effect of atrial natriureticpeptide(ANP)and its signaling pathway during ortho-topic rat liver transplantation.METHODS:Rats were infused with NaCl,ANP(5 μg/kg),wortmannin(WM,16 μg/kg),or a combination ofboth for 20 min.Livers were stored in UW solution(4°C)for 24 h,transplanted and reperfused.Apoptosis wasexamined by caspase-3 activity and TUNEL staining.Phosphorylation of Akt and Bad was visualized by West-ern blotting and phospho-Akt-localization by confocalmicroscopy.RESULTS:ANP-pretreatment decreased caspase-3activity and TUNEL-positive cells after cold ischemia,indicating antiapoptotic effects of ANP in vivo.The an-tiapoptotic signaling of ANP was most likely caused byphosphorylation of Akt and Bad,since pretreatment withPI 3-kinase inhibitor WM abrogated the ANP-inducedreduction of caspase-3 activity.Interestingly,analysis ofliver tissue by confocal microscopy showed translocationof phosphorylated Akt to the plasma membrane of hepa-tocytes evoked by ANP.CONCLUSION:ANP activates the PI-3-kinase pathwayin the liver in vivo leading to phosphorylation of Bad, an event triggering antiapoptotic signaling cascade inischemic liver. | Uwe Grutzner Melanie Keller Michael Bach Alexandra K Kiemer Herbert Meissner Manfred Bilzer Stefan Zahler Alexander L Gerbes Angelika M Vollmar | 2006 | World Journal of Gastroenterology2006，12，7： | 3 |
| 3 | 带双质量飞轮的动力传动系统各种工况的仿真显示文摘节约实车试验和减少开发周期和成本的一个必不可少的工具是通过各种行驶条件下的仿真来确定双质量飞轮(DMF)的最优参数。另外,仿真还能确定应用于当前设计的新方法的效能。 | Hartmut Bach Wolfgang Kücks Michael Triebel ZF Sachs AG Schweinfurt | 2008 | 传动技术2008，22，3： | 3 |
| 4 | Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway 显示文摘 | Melero 1 Bach N Hellstrom K E | 1998 | Eur J Immunol1998，28，3： | 1 |
| 5 | Conversational Impliciture 显示文摘 | Bach K | 1994 | Mind and Lan- guage1994，，9： | 1 |
| 6 | Biphoton-indueed refractive index change in 4-amino-4' -nitroazobenzene/polycarbonate 显示文摘 | BACH H ANDERLE K FUHRMANN T | 1996 | J Phys Chem1996，100，： | 1 |
| 7 | Default reasoning: Jumping to conclusions and knowing when to think twice显示文摘 | Bach K | 1984 | Pacific Philosophical Quarterly1984，，65： | 1 |
| 8 | A Tumor-Associated Mutation of FYVE-CENT Prevents Its Interaction with Beclin 1 and Interferes with Cytokinesis显示文摘 | Sagona A P Nezis I P Bache K G | | 0，，03： | 1 |
| 9 | Easy and rapid method of zygosity determination in transgenic mice by SYBR?Green real-time quantitative PCR with a simple data analysis显示文摘 | HaurognéK Bach J M Lieubeau B | 2007 | Transgenic Res2007，16，1： | 1 |
| 10 | Carbohydrate and lignin contents of plant materials used in animal feeding 显示文摘 | Bach Knudsen K E | 1997 | Anim Feed Sci Technol1997，67，： | 1 |
| 11 | The nutritional significance of dietary 'fibre'analysis显示文摘 | BACH KNUDSEN K E | 2001 | Animal Feed Science and Technology2001，90，： | 1 |
| 12 | Inhibition by mevinolin of plant growth, sterol formation and pigment accumulation 显示文摘 | BACH T J LICHTENTHALER H K | 1983 | Physiologia Plantarum1983，59，1： | 1 |
| 13 | Roles of insulin-like growth factor (IGF) receptors and IGF-binding proteins in IOF-II-induced proliferation and differentiation of L6AI rat myoblasts 显示文摘 | Bach L A Salerni IL Leeding K S | 1995 | Endocrinology1995，136，： | 1 |
| 14 | Medium- chain triglycerides: an update显示文摘 | BACH A C BABAYAN V K | 1982 | Am J Clin Nutr1982，36，5： | 1 |
| 15 | Carbohydrate and lignin contents of plant materials used in animal feeding 显示文摘 | BACH KNUDSEN K E | 1997 | Animal Feed Science and Technology1997，67，： | 1 |
| 16 | Towards Knowledge Networking显示文摘 | Andreas Seufert G v K Andrea Bach | | 0，，03： | 1 |
| 17 | Resistant starch for weaning pigs-effect on concentration of short chain fatty acids in digesta and intestinal morphology显示文摘 | Hedemaun M S Bach Knudsen K E | 2007 | Livestock Science2007，108，： | 1 |
| 18 | Amplification of tumor immunity lay gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway显示文摘 | Melero I Bach N Hellsmm K E | 1998 | Eur J Immunol1998，28，： | 1 |
| 19 | Corrosion fatigue of a 12%Cr lowpressure turbine blade steel in simulated service environments显示文摘 | Perkins K M Bache M R | 2005 | International Journal of Fatigue2005，27，1020： | 1 |
| 20 | Ligand binding by PDZ domains显示文摘 | CHIC N BACH A STR?MGAARD K | 2012 | Biofactors2012，38，5： | 1 |
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