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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | Anti-microbial principles of selected remedial plants from Southern India显示文摘Objective:To examine the anti-bacterial activity of leaf extracts of Morus alba L.(Moraceae)and Piper betel L.(Piperaceae),and seed extracts of Bombax ceiba L.(Borabacaceae).Methods:We have partially purified plant extracts by solvent extraction method,and evaluated the effect of individual fractions on bacterial growth using Escherichia coli(E.coli),Pseudomonas aeruginosa(P.aeruginosa) and Staphylococcus aureus(S.aureus) bacterial strains.Results:Compared with Morus and Bombax fractions,Piper fractions showed significant growth inhibition on all the three types of bacteria studied.The EtOAc-hexane fractions of Piper leaves exhibited significant antibacterial activity with minimum inhibitory concentrations(MIC) of 50 μg/mL culture against both gram-positive and gram-negative bacteria.The EtOAc-fractions Ⅰ,Ⅱ,and Ⅳ inhibited bacterial colony formation on soft agar in addition to growth inhibition.A combination treatment of piper fractions with ampicillin resulted in significant growth inhibition in E.coli and P.aeruginosa,and combination with anticancer drug geldanamycin(2 μg/mL) showed selective growth inhibition against P.aeruginosa and S.aureus.Three major compounds,i.e.,eugenol,3-hexene-ol and stigmasterol,were primarily identified from Piper betel leaf extractions.Among the individual compounds,eugenol treatment showed improved growth inhibition compared with stigmasterol and 3-hexene-ol.Conclusions:We are reporting potential anti-bacterial compounds from Piper betel against both gram-positive and gram-negative bacteria either alone or in combination with drug treatment. | Tirupathi Rao G Suresh Babu K J Ujwal Kumar Sujana P A Veerabhadr Raoa Sreedhar AS | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 5 |
| 3 | Immuohistochemical localization of bursin in epithelial cell of the avian bursa of Fabricius显示文摘 | Viamonts G T Audhya T K Babu U | 1989 | The Journal of Histochemistry and Cytochemistry1989，37，6： | 2 |
| 4 | Bursin localization in mammailianbone marrow and epithelial ceel is of intrahepatic bile ducts Scarld 显示文摘 | Audhya T Viamontes G Babu U | 1990 | Jmmunol1990，31，： | 2 |
| 5 | Effect of thermal cycling on friction stir welds of 2195 aluminum alloy显示文摘 | S S Babu S A David E A Kenik | 2001 | Welding journal2001，80，3： | 1 |
| 6 | Switched bias proportional navigation for homing guidance against highly maneuvering target 显示文摘 | K R Babu J G Sarmah K N Swamy | 1994 | Journal of Guidance Control and Dynamics1994，17，6： | 1 |
| 7 | Production and structural characterization of crystalline silver nanoparticles from Bacillus cereus isolate显示文摘 | Babu M M G Gunasekaran P | 2009 | Colloids and Surfaces B: Biointerfaces2009，74，1： | 1 |
| 8 | Gastroprotective flavonoid constituents from Oroxylum indicum Vent显示文摘 | Had Babu T Manjulatha K Suresh Kumar G | 2010 | Bioorg Med Chem Lett2010，20，1： | 1 |
| 9 | Identification and molec- ular characterization of two naturally occurring soybean mosaic vi- rus isolates that are closely related but differ in their ability to o- vercome Rsv4 resistance显示文摘 | Gagarinova A G Babu M Poysa V | 2008 | Virus Research2008，138，12： | 1 |
| 10 | Peri-procedural myocardial injury during percutaneous coronary intervention: an important target for cardio- protection显示文摘 | BABU G G WALKER J M YELLON D M | 2011 | Eur HeartJ2011，32，： | 1 |
| 11 | Attenuation of ischemia and/or reperfurion injury during myocardial infarction using mild hypothermia in rats: an immunohistochemical study of bcl- 2, bax, Bak and TUNEL显示文摘 | Babu PP Suzuki G Ono Y | 2004 | Pathol Int2004，54，12： | 1 |
| 12 | Case-based, team-based learning: a novel method for teaching orofacial syn- dromology to dental undergraduate students 显示文摘 | SHETFY S R BABU G S CASTELINO R | 2015 | Educ Health (Abingdon)2015，28，1： | 1 |
| 13 | Investigation on Laser Dressing of Grinding Wheels-Part: Preliminary Study显示文摘 | RAMESH BABU N RADHAKRISHNAN V MURTI Y V G S | 1989 | Transaction of ASME Journal of Engineering for Industry1989，111，： | 1 |
| 14 | Characterization of volatile components of Kangra orthodox black tea by gas chromatography-mass spectrometry显示文摘 | Rawat R Gulati A Kiran Babu G D | 2007 | Food Chemisty2007，107，： | 1 |
| 15 | Evaluation of shear strength functions based on soil water characteristic curves显示文摘 | BABU G L S RAO R S PETER J | | 0，，06： | 1 |
| 16 | Characterization of volatile components of Kangra orthodox blacktea by gas chromatography-mass spectrometry显示文摘 | Rawat R Gulati A Babu G K | 2007 | Food Chemistry2007，105，1： | 1 |
| 17 | Tropical clays II : Engineering behavior显示文摘 | PANDIAN N S NAGARAJ T S SIVAKUMAR BABU G L | 1993 | Journal of Geotechnieai Engineering1993，119，： | 1 |
| 18 | Face recognition based on Eigen features of multi scaled face components and an artificial neural network显示文摘 | Reddy K R L Babu G R Kishore L | 2010 | Procedia computer science2010，2，3： | 1 |
| 19 | Attenuation of ischemia and/or reperfusion injury during myocardial infarction using mild hypothermia in rats: an immunohistochemical study of Bcl-2, Bax, Bak and TUNEL显示文摘 | Babu PP Suzuki G Ono Y | 2004 | Pathol Int2004，54，12： | 1 |
| 20 | Effect of thermal cycling on friction stir welds of 2195 aluminum alloy 显示文摘 | Oertelt G Babu S S David S A | 2001 | Welding Journal2001，80，3： | 1 |
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