|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MicroRNAs:Role in hepatitis C virus pathogenesis显示文摘Hepatitis C virus(HCV)is a global health burden with an estimated 170e200 million peoples chronically infected worldwide.HCV infection remains as an independent risk factor for chronic hepatitis,liver cirrhosis,hepatocellular carcinoma,and a major reason for liver transplantation.Discovery of direct acting antiviral(DAA)drugs have shown promising results with more than 90%success rate in clearing the HCV RNA in patients,although long-term consequences remain to be evaluated.microRNAs(miRNAs)are important players in establishment of HCV infection and target crucial host cellular factors needed for productive HCV replication and augmented cell growth.Altered expression of miRNAs is involved in the pathogenesis associated with HCV infection by controlling signaling pathways such as immune response,proliferation and apoptosis.miRNA is emerging as a means of communication between various cell types inside the liver.There is likely possibility of developing circulating miRNAs as biomarkers of disease progression and can also serve as diagnostic tool with potential of early therapeutic intervention in HCV associated end stage liver disease.This review focuses on recent studies highlighting the contribution of miRNAs in HCV life cycle and their coordinated regulation in HCV mediated liver disease progression. | Shubham Shrivastava Robert Steele Ranjit Ray Ratna B.Ray | 2015 | Genes & Diseases2015，2，1： | 6 |
| 2 | The origin of lunar crater rays显示文摘 | B.Ray Hawke D.T. Blewett P.G. Lucey G.A. Smith J.F. Bell B.A. Campbell M.S. Robinson | 2004 | Icarus2004，，1： | 2 |
| 3 | Thymocytes, Pre‐B Cells, and Organ Changes in a Mouse Model of Chronic Ethanol Ingestion—Absence of Subset‐Specific Glucocorticoid‐Induced Immune Cell Loss显示文摘 | Robert T.Cook Annette J.Schlueter Ruth A.Coleman LorraineTygrett Zuhair K.Ballas Thomas R.Jerrells Marcus B.Nashelsky Nancy B.Ray Thomas H.Haugen Thomas J.Waldschmidt | 2007 | Alcoholism: Clinical and Experimental Research2007，，10： | 1 |
| 4 | Oblique Drop Impact on Deep and Shallow Liquid显示文摘Numerical simulations using CLSVOF(coupled level set and volume of fluid)method are performed to investigate the coalescence and splashing regimes when a spherical water drop hits on the water surface with an impingement angle.Impingement angle is the angle between the velocity vector of primary drop and the normal vector to water surface.The effect of impingement angle,impact velocity and the height of target liquid are carried out.The impingement angle is varied from 0o to 90o showing the gradual change in phenomena.The formation of ship pro like shape,liquid sheet,secondary drops and crater are seen.Crater height,crater displacement,crown height and crown angle are calculated and the change in the parameters with change in impingement angle is noted. | B.Ray G.Biswas A.Sharma | 2012 | Communications in Computational Physics2012，11，4： | 1 |
| 5 | Rotational asymmetry of reactant concentration and its evolution in a circulating fluidized bed riser显示文摘Rotational asymmetric distribution of reactant (ozone) concentration and its evolution along with the gas-solid reactive flow were studied in a 76 mm i.d., 10.2 m high circulating fluidized bed (CFB) riser reactor. The superficial gas velocity ranged from 3 to 5 m/s and the solids circulation rates were 50 and 100 kg/(m2 s). Experimental results show that the asymmetry of reactant distribution can extend to a height close to the length of flow developing zone of the CFB riser reactor and then disappears. Based on the hydrodynamics of the gas and solid phases in the solids entrance region, this asymmetry can be attributed to the effect of the solids entrance structure. | Ajay K.Ray Madhumita B.Ray Jesse Zhu | 2012 | Particuology2012，10，5： | 1 |
| 6 | Diverse roles of bitter melon(Momordica charantia)in prevention of oral cancer显示文摘Oral squamous cell carcinoma(OSCC)is one of the common lethal malignancies which is increasing rapidly in the world.Increasing risks from alcohol and tobacco habits,lack of early detection markers,lack of effective chemotherapeutic agents,recurrence and distant metastasis make the disease more complicated to manage.Laboratory-based studies and epidemiological studies indicate important roles of nutraceuticals to manage different cancers.The plant bitter melon(Momordica charantia)is a good source of nutrients and bio-active phytochemicals such as triterpenoids,triterpene glycosides,phenolic acids,flavonoids,lectins,sterols and proteins.The plant is widely grown in Asia,Africa,and South America.Bitter melon has traditionally been used as a folk medicine and Ayurvedic medicine in Asian culture to treat diseases such as diabetes,since ancient times.The crude extract and some of the isolated pure compounds of bitter melon show potential anticancer effects against different cancers.In this review,we shed light on its effect on OSCC.Bitter melon extract has been found to inhibit cell proliferation and metabolism,induce cell death and enhance the immune defense system in the prevention of OSCC in vitro and in vivo.Thus,bitter melon may be used as an attractive chemopreventive agent in progression towards OSCC clinical study. | Subhayan Sur Ratna B.Ray | 2021 | Journal of Cancer Metastasis and Treatment2021，7，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员