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| 1 | Effect of minor amounts of β-calcium pyrophosphate and hydroxyapatite on the physico-chemical properties and osteoclastic resorption of β-tricalcium phosphate cylinders显示文摘β-Tricalcium Phosphate(β-TCP),one of the most used bone graft substitutes,may contain up to 5 wt%foreign phase according to standards.Typical foreign phases includeβ-calcium pyrophosphate(β-CPP)and hydroxyapatite(HA).Currently,the effect of small amounts of impurities on β-TCP resorption is unknown.This is surprising since pyrophosphate is a very potent osteoclast inhibitor.The main aim of this study was to assess the effect of small β-CPP fractions(<1 wt%)on the in vitro osteoclastic resorption of β-TCP.A minor aim was to examine the effect of β-CPP and HA impurities on the physico-chemical properties of β-TCP powders and sintered cylinders.Twenty-six batches of β-TCP powder were produced with a Ca/P molar ratio varying between 1.440 and 1.550.Fifteen were further processed to obtain dense and polished β-TCP cylinders.Finally,six of them,with a Ca/P molar ratio varying between 1.496(1 wt% β-CPP)and 1.502(1 wt% HA),were incubated in the presence of osteoclasts.Resorption was quantified by white-light interferometry.Osteoclastic resorption was significantly inhibited by β-CPP fraction in a linear manner.The presence of 1% β-CPP reduced β-TCP resorption by 40%,which underlines the importance of controllingβ-CPP content when assessing β-TCP biological performance. | B.Le Gars Santoni L.Niggli S.Dolder O.Loeffel G.A.Sblendorio R.Heuberger | 2022 | Bioactive Materials2022，7，4： | 3 |
| 2 | Transient elastography and biomarkers for liver fibrosis assessment and follow‐up of inactive hepatitis B carriers显示文摘 | L.Castéra P.‐H.Bernard B.Le Bail J.Foucher P.Trimoulet W.Merrouche P.Couzigou V.de Lédinghen | 2011 | Alimentary Pharmacology & Therapeutics2011，，4： | 2 |
| 3 | A new version of the two hybrid assay for detection of protein-protein interactions显示文摘 | B.Le Douarin eta1 | | 0，，05： | 1 |
| 4 | A full vectorial mapping of nanophotonic light fields显示文摘Light is a union of electric and magnetic fields,and nowhere is the complex relationship between these fields more evident than in the near fields of nanophotonic structures.There,complicated electric and magnetic fields varying over subwavelength scales are generally present,which results in photonic phenomena such as extraordinary optical momentum,superchiral fields,and a complex spatial evolution of optical singularities.An understanding of such phenomena requires nanoscale measurements of the complete optical field vector.Although the sensitivity of nearfield scanning optical microscopy to the complete electromagnetic field was recently demonstrated,a separation of different components required a priori knowledge of the sample.Here,we introduce a robust algorithm that can disentangle all six electric and magnetic field components from a single near-field measurement without any numerical modeling of the structure.As examples,we unravel the fields of two prototypical nanophotonic structures:a photonic crystal waveguide and a plasmonic nanowire.These results pave the way for new studies of complex photonic phenomena at the nanoscale and for the design of structures that optimize their optical behavior. | B.le Feber J.E.Sipe M.Wulf L.Kuipers N.Rotenberg | 2019 | Light(Science & Applications)2019，8，1： | 0 |
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