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| 1 | Promoting remyelination for the treatment of multiple sclerosis:opportunities and challenges显示文摘Multiple sclerosis (MS) is a chronic and devastating autoimmune demyelinating disease of the central nervous system. With the increased understanding of the pathophysiology of this disease in the past two decades, many disease-modifying therapies that primarily target adaptive immunity have been shown to prevent exacerbations and new lesions in patients with relapsing-remitting MS. However, these therapies only have limited efficacy on the progression of disability. Increasing evidence has pointed to innate immunity, axonal damage and neuronal loss as important contributors to disease progression. Remyelination of denuded axons is considered an effective way to protect neurons from damage and to restore neuronal function. The identification of several key molecules and pathways controlling the differentiation of oligodendrocyte progenitor cells and myelination has yielded clues for the development of drug candidates that directly target remyelination and neuroprotection. The long-term efficacy of this strategy remains to be evaluated in clinical trials. Here, we provide an overview of current and emerging therapeutic concepts, with a focus on the opportunities and challenges for the remyelination approach to the treatment of MS. | Yueting Zhang Taylor B.Guo Hongtao Lu | 2013 | Neuroscience Bulletin2013，29，2： | 6 |
| 2 | A quantitative microplasticity-based approach to rationalize the poor strengthening response of polycrystalline Mg alloys显示文摘This work aims to understand the inefficiency of nanoprecipitates to strengthen a weakly textured,polycrystalline Mg-Gd-Y-Zr alloy.An experimental micromechanical approach consisting on micropillar compression combined with analytical electron microscopy is put in place to analyze the effect of nanoprecipitation on soft and hard basal slip and twinning in individual grains with different orientations.This study shows that,in grains that are favorably oriented for basal slip(“soft”basal slip),aging leads to extreme localization due to the ability of basal dislocations to shear the nanoparticles,resulting overall in the softening of basal systems.Additionally,in grains in which the c-axis is almost perpendicular to the compression axis,prismatic slip dominates deformation in the solid solution state and nanoprecipitation favors twinning due to the concomitant lattice solute depletion.Finally,in grains oriented with their c-axis making an angle of about 5-7°with respect to the compression axis,which deform mainly by“hard”basal slip,precipitation leads to the strengthening of basal systems in the absence of obvious localization.This work reveals that the poor hardening response of the polycrystalline alloy is related to the capability of basal dislocations to shear the nanoparticles,in the absence of Orowan looping events,and to the associated basal slip localization. | X.Z.Jin W.C.Xu D.B.Shan B.Guo B.Jin M.T.Pérez-Prado | 2023 | Journal of Magnesium and Alloys2023，11，5： | 1 |
| 3 | QTL analysis of seed storability in rice显示文摘 | D. L.Zeng L. B.Guo Y. B.Xu K.Yasukumi L. H.Zhu Q.Qian | 2006 | Plant Breeding2006，，1： | 1 |
| 4 | Dissection of component QTL expression in yield formation in rice显示文摘 | L. B.Guo Y. Z.Xing H. W.Mei C. G.Xu C. H.Shi P.Wu L. J.Luo | 2008 | Plant Breeding2008，，2： | 1 |
| 5 | 查看详情显示文摘 | Li X Choy W.C Huo L Xie F.Sha W.E.Ding B.Guo X.Li Y.Hou J.You J | | 0，，： | 1 |
| 6 | 天然裂缝性斯普拉伯雷走向带油藏渗吸注水开发的综合研究显示文摘为了掌握斯普拉伯雷走向带低渗透、天然裂缝性油藏的水驱动态,开展了渗吸注水开发综合研究。该项研究中,根据控制传质的速率法則,采用数学方法分析了天然裂缝性油藏渗吸注水期间的原油产量。并已开发出基于吸渗理论的产量递减曲线分析的分析模型。在实验和油藏条件下,利用油藏原油、合成油藏盐水和低渗透油藏岩心进行了渗吸和毛细管压力实验。从中观察到试验结果与采用试验数据增大标度和拟合油藏动态的结果一致。并从中发现注水过程中,水缓慢渗吸进入弱亲水基质岩决是限制采收率的主要因素。该研究提出:高效益的注水开发应寻找那些基质渗透率高,裂缝强度大和高含油饱和度的区域。 | B.Guo 曾中立 乔向阳 | 1999 | 吐哈油气1999，0，1： | 0 |
| 7 | 利用IPR方程预测长裂缝油藏水平井及直井产量显示文摘 | B.GUO 许房燕 张永昭 | 2001 | 特种油气藏2001，8，2： | 0 |
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