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| 1 | Reversibility of minimal hepatic encephalopathy following liver transplantation in Egyptian cirrhotic patients显示文摘AIM To evaluate the reversibility of minimal hepatic encephalopathy(MHE) following liver transplantation(LT) in Egyptian cirrhotic patients. METHODS This prospective study included twenty patients with biopsy-proven liver cirrhosis listed for LT and twenty ageand sex-matched healthy control subjects. All underwent neuro-psychiatric examination, laboratory investigations, radiological studies and psychometric tests including trail making test A(TMT A), TMT B, digit symbol test and serial dotting test. The psychometric hepatic encephalopathy score(PHES) was calculated for patients to diagnose MHE. Psychometric tests were repeated six months following LT in the cirrhotic patient group. RESULTS Before LT, psychometric tests showed highly significant deficits in cirrhotic patients in comparison to controls(P < 0.001). There was a statistically significant improvement in test values in the patient group after LT; however, their values were still significantly worse than those of the controls(P < 0.001). The PHES detected MHE in 16 patients(80%) before LT with a median value of -7 ± 3.5. The median PHES value was significantly improved following LT, reaching-4.5 ± 5(P < 0.001), and the number of patients with MHE decreased to 11(55%). The pre-transplant model for end-stage liver disease(MELD) score ≥ 15 was significantly related to the presence of post-transplant MHE(P = 0.005). More patients in whom reversal of MHE was observed had a pre-transplant MELD score < 15.CONCLUSION Reversal of MHE in cirrhotic patients could be achieved by LT, especially in those with a MELD score < 15. | Mahmoud A Osman Moataz M Sayed Khaled A Mansour Shereen A Saleh Wesam A Ibrahim Sara M Abdelhakam Mohamed Bahaa Wael A Yousry Hosam S Elbaz Reginia N Mikhail Azza M Hassan Ehab H Elsayed Dalia A Mahmoud | 2016 | World Journal of Hepatology2016，8，30： | 11 |
| 2 | Biochemical changes in phenols,flavonoids,tannins,vitamin E,β-carotene and antioxidant activity during soaking of three white sorghum varieties显示文摘Objective:To investigate the changes in total phenols,flavonoids,tannins,vitamin E, β-carotene and antioxidant activity during soaking of three white sorghum varieties.Methods: The changes in total phenols,total ilavonoids,tannins,phenolic acids compounds,flavonoid components,vitamin E,P-carotene and antioxidant activity during soaking of sorghum grains were determined.Results:Total phenols,total flavonoids,tannins,vitamin E,P-carotene and antioxidant activity in raw sorghum were ranged from 109.21 to 116.70,45.91 to 54.69,1.39 to 21.79 mg/100 g,1.74 to 5.25,0.54 to 1.19 mg/kg and 21.72%to 27.69%and 25.29%to 31.97%,respectively. The above measured compounds were significantly decreased after soaking.p-Hydroxybenzoic acid,vanillic acid,syringic acid and cinnamic acid represent the major phenolic acids in Dorado variety.While ferulic acid,p-coumaric acid,gallic acid and caffeic acid represent the major phenolic acids in Shandaweel-6.On the other hand,protocatechuic acid represents the major phenolic acids in Giza-15.Regarding flavonoids components,Dorado was the highest variety in kampferol and naringenin while Shandaweel-6 was the highest variety in luteolin, apigenin,hypersoid,quercelin and christen.Finally,Giza-15 was the highest variety in catechin. Phenolic acids,flavonoid compounds and antioxidant activities were decreased after soaking. Conclusions:Sorghum varieties have moderate quantities from total phenols,total flavonoids, tannins,phenolic acids compounds,flavonoid components,vitamin E,P-carotene and antioxidant activity which decreased after soaking. | Abd El-Moneim MR Afify Hossam S El-Beltagi Samiha M Abd El-Salam Azza A Omran | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，3： | 7 |
| 3 | Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma显示文摘AIM:To investigate cell cycle proteins in chronic hepatitis C virus infection in order to analyze their role in the process of hepatocyte transformation and to characterize their prognostic properties. METHODS:Subjects of the current study included 50 cases of chronic hepatitis C(CHC) without cirrhosis,30 cases of CHC with liver cirrhosis(LC) ,and 30 cases of hepatitis C-related hepatocellular carcinoma(HCC) admitted to the Department of Hepato-Gastroenterology,Theodor Bilharz Research Institute(TBRI) ,Giza,Egypt.Fifteen wedge liver biopsies,taken during laparoscopic cholecystectomy,were also included as normal controls.Laboratory investigations including urine and stool analysis,liver function tests and prothrombin concentration;serologic markers for viral hepatitis and ultrasonography were done for all cases of the study together with immunohistochemical analysis using primary antibodies against Cyclin D1,Cyclin E,p21,p27 and Rb/p105 proteins. RESULTS:Normal wedge liver biopsies didn't express Cyclin E or Rb/p105 immunostaining but show positive staining for Cyclin D1,p21 and p27.Cyclin D1 expressed nuclear staining that was sequentially increased from CHC to LC(P<0.01) to HCC(P<0.001) cases;meanwhile,Cyclin E revealed nuclear positivity only in the case of HCCs patients that was directly correlated to Rb/p105 immuno-reactivity.The expression of p21 and p27 was significantly increased in CHC and LC cases compared to normal controls and HCCs with no significant difference between well-and poorlydifferentiated tumors.p21 showed only a nuclear pattern of staining,while,p27 presented with either cytoplasmic and/or nuclear reactivity in all studied cases.Correlation analysis revealed a direct relation between Cyclin D1 and p21 in CHC cases(P<0.001) ,between Cyclin D1 and Cyclin E in HCCs(P<0.01);however,an inverserelationship was detected between Cyclin D1 and p21 or p27(P<0.001) and between p21 and Rb/p105(P<0.05) in HCCs. CONCLUSION:Upregulation of Cyclin D1 in CHC plays a vital role in the development and differentiation of HCC;while,Cyclin E may be a useful marker for monitoring tumor behavior.p21 and p27 can be used as predictive markers for HCC.Furthermore,higher expression of Rb/p105 as well as inverse relation with p21 and histologic grades suggests its important role in hepatic carcinogenesis. | Azza E El Bassiouny Mona M Nosseir Mona K Zoheiry Noha A Ameen Ahmed M Abdel-Hadi Ibrahim M Ibrahim Suher Zada Abdel-Hakeem Saad El-Deen Nora E El-Bassiouni | 2010 | World Journal of Hepatology2010，2，1： | 3 |
| 4 | Vitamin D status and viral response to therapy in hepatitis C infected children显示文摘AIM: To study the frequency of vitamin D deficiency in patients with hepatitis C virus(HCV) infection and to evaluate the role of vitamin D supplementation in improving antiviral therapy.METHODS: Sixty-six children aged from 7-14 years(mean ± SD, 11.17 ± 2.293) diagnosed with HCV infection were matched to 28 healthy controls. Serum levels of 25(OH) D3, calcium, phosphorus, alkaline phosphatase and plasma level of parathormone were measured. Quantitative PCR for HCV was performed Bone density was determined by dual energy X-ray absorptiometry. All cases received conventional therapy, and only 33 patients received vitamin D supplementation.RESULTS: Children with HCV showed significantly increased levels of HCV RNA(P < 0.001), parathormone(P < 0.01) and decreased vitamin D levels(P < 0.05)(33.3% deficient and 43.3% insufficient) compared with controls. Abnormal bone status(Z score-1.98 ± 0.75) was found in ribs, L-spine, pelvis and total body. Cases treated with vitamin D showed significant higher early(P < 0.04) and sustained(P < 0.05) virological response. There was a high frequency of vitamin D deficiency among the Egyptian HCV children, with significant decrease in bone density. The vitamin D level should be assessed before the start of antiviral treatment with the correction of any detected deficiency. CONCLUSION: Adding vitamin D to conventional Peg/RBV therapy significantly improved the virological response and helped to prevent the risk of emerging bone fragility. | Azza A Eltayeb Madleen Adel A Abdou Amal M Abdel-aal Mostafa H Othman | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 5 | Comprehensive risk assessment of heavy metals in surface sediments along the Egyp- tian Red Sea coast显示文摘 | Dalia M S A S Azza K Ahmed E N | 2014 | The Egyptian Journal of Aquatic Research2014，40，4： | 1 |
| 6 | Nanobacteria are mineralofetuin complexes显示文摘 | Raoult D Drancourt M Azza S | 2008 | PLoS Pathog2008，4，2： | 1 |
| 7 | Nanobacteria are mineralo fetuin complexes 显示文摘 | RAOULT D DRANCOURT M AZZA S | 2008 | PloS Pathog2008，4，2： | 1 |
| 8 | Effects of obstructive sleep ap- nea on cognitive function on: acomparison between younger and old er OSAS patients显示文摘 | M athieu A M azza S D eary A | 2008 | Sleep Med2008，9，2： | 1 |
| 9 | Control of fusarium moulds and fumonisin B1 in seeds by gammairradiation 显示文摘 | Nagy H Aziz Ferial M El-Far Azza A M Shahin | 2007 | Food Control2007，18，： | 1 |
| 10 | Spectrophotometric Methods for the Determination of Lansoprazole and Pantoprazole Sodium Sesquihydrate显示文摘 | AZZA A M M | 2000 | Journal of Pharmaceutical and Biomedical Analysis(S0371-7085)2000，22，1： | 1 |
| 11 | Spectrophotometric Determination of Omeprazole,Lansoprazole and Pantoprazole in Pharmaceutical Formulations显示文摘 | ABDEL-Aziz M W OMAYMA A R AZZA A G | 2002 | Journal of Pharmaceutical and Biomedical Analysis(S0371-7085)2002，30，4： | 1 |
| 12 | UV-Spectrophotometric Stability Indicating Methods for the Quantitative Determination of Cimetidine,Famotidine,and Ranitidine Hydrochloride in the Presence of their Oxidative Derivatives显示文摘 | Khadiga M Kelani Azza M Aziz Maha A | 2002 | Analytical Letters2002，35，6： | 1 |
| 13 | Application of infrared spectros- copy in the study of polymorphism of hydrogenated canola oil显示文摘 | AZZA N M DEMAN J M | 1985 | J Am Oil Chem Soc1985，62，10： | 1 |
| 14 | Pneumoslide-M tech- nique for rapid detection of atypical pathogens in critically ill chil- dren with lower respiratory tract infections显示文摘 | Sally A F Azza M O Eman A E | 2006 | J Med Sci2006，6，5： | 1 |
| 15 | GAD Effect of pumpkin-seed oil on the level of free radical scav-engers induced during adjuvant-arthritis in rays显示文摘 | Fahim amal A Abd-el Fattah azza M Agha | 2000 | Pharmaco-logical Research2000，，41： | 1 |
| 16 | Polymorphism of hydrogenated canola oil 显示文摘 | AZZA N M DEMAN J M | 1985 | J Am Oil Chem Soc1985，62，4： | 1 |
| 17 | Polymorphism of hydrogenated canola oil 显示文摘 | AZZA N M DEMAN J M | 1985 | J Am Oil Chem Soc1985，62，4： | 1 |
| 18 | Characterization of some bacteria isolated from Oreochromis niloticus and their potential use as probiotics 显示文摘 | Salah M A Azza M A George J | 2008 | Aquaculture2008，277，： | 1 |
| 19 | A comprehensive characterization of corn stalk and study of carbonized corn stalk in dye and gas oil sorption 显示文摘 | Husseien M Amer A A EI-Maghraby Azza | 2009 | Journal of Analytical and Applied Pyrolysis2009，86，2： | 1 |
| 20 | Control of Fusarlum moulds and fumonisin B1 in seeds by gammairradiation显示文摘 | Nagy H Aziz Ferial M El-Far Azza A M Shahin Souzan M Roushy | 2007 | Food Control2007，18，： | 1 |
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