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172篇 您的检索式：作者名="Aziz O"

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	题名	作者	年代	出处	被引量
1	IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients显示文摘AIM:To test whether the status of positive cytomegalovirus(CMV) DNA detection adds to the predictive value of IL28B and to further categorize C/T allele carriers.METHODS:This study included 166 chronic hepatitis C(CHC) patients who received combined interferon and ribavirin therapy for 48 wk,84 spontaneous hepatitis C virus(HCV) resolvers who were positive for IgG anti-HCV antibody and negative for HCV RNA,and 100 healthy subjects who were negative for both HCV antibodies and RNA as controls.Genomic DNA from peripheral blood was used for IL28B rs.12979860 single nucleotide polymorphism(SNP) and CMV DNA detection.A 139 bp fragment containing IL28B SNP was amplified in all subjects by polymerase chain reaction using a specifically designed primer.Then the IL28B rs.12979860 SNP was detected by restriction fragment length polymorphism(RFLP) genotyping.The presence of CMV DNA was tested by amplification of the gB1 gene using nested polymerase chain reaction.The role of CMV and IL28B rs.12979860 SNP genotypes in determining the response rate to combined interferon therapy and clinical status of patients were statistically analyzed.RESULTS:Current data showed that 67% of patients carrying the IL28B 12979860 C/C allele had a sustained viral response(SVR) while the genotypes C/T and TT were associated with lower SVR rates,50% and 48%,respectively.SVR rates for the C/C allele were lower than other HCV genotypes and/or other populations.Genotype CC was associated with the response to interferon(P = 0.025).Genotype C/C was reduced from 48% in controls to 14% in CHC patients suggesting its protective role against progression to chronicity.The majority of spontaneously cleared subjects(86%) were C/C,confirming its protective role.The C/T allele was present in 71% of CHC patients compared with 38% of controls,so the use of IL28B SNP genotyping only in these patients may be of little value as a predictor of response.CMV reactivation occurred in 40% of CHC patients.Co-infection with CMV seriously diminished the response to interferon(IFN) therapy,with SVR rates in C/C genotypes 87.5% in CMV-negative patients and 12.5% in CMV-positive patients(P < 0.0001).SVR rates among C/T carriers were reduced to < 50% in patients with positive CMV DNA while the non-response rate doubled.These data indicate that a supplemental assay for CMV viremia adds to the prognostic value of IL28B genotyping.CONCLUSION:The results suggest that both genetic(i.e.,spontaneous) and therapeutic(IFN-based therapy) arms are complementary in the battle against HCV.CMV DNA testing may be of value to better predict the response to IFN,particularly in IL28B C/T carriers.	Mostafa K El Awady Noha G Bader El Din Ashraf Tabll Yaser El Hosary Ashraf O Abdel Aziz Hesham El Khayat Mohsen Salama Tawfeek H Abdelhafez	2013	World Journal of Gastroenterology2013，19，2：	8
2	Laparoscopic versus open surgery for rectal cancer:a meta-analysis显示文摘	Aziz O Constantinides V Tekkis PP	2006	Ann Surg Oncol2006，13，3：	1
3	Laparoscopic resection for colorectal cancer: evidence to date显示文摘	Aziz O Darzi AW	2008	Surg Oncol Clin N Am2008，17，3：	1
4	Can depth of tumour invasion predict lymph node positivity in patients undergoing resection for early rectal cancer? A comparative study between T1 and T2 cancers显示文摘	Rasheed S Bowley DM Aziz O	2008	Colorectal Dis2008，10，3：	1
5	Single-incision laparoscopic surgery for cholecystectomy:a retrospective comparison with 4-port laparoscopic cholecystectomy 显示文摘	Chow A Purkayastha S Aziz O	2010	Arch Surg2010，145，12：	1
6	Does mini- mally invasive vein harvesting technique affect the quali- ty of the conduit for coronary revascularization? 显示文摘	Aziz O Athanasiou T Panesar S S	2005	Ann Thorac Surg2005，80，6：	1
7	Laparoseopic versus open surgery for rectal eaneer:a meta-analysis 显示文摘	Aziz O Constantinides V Tekkis PP	2006	Ann Surg On- col2006，3，13：	1
8	Evaluating operative risk in colorectal cancer surgery: ASA and POSSUM-based predictive models 显示文摘	Al-Homoud S Purkayastha S Aziz O	2004	SurgOncol2004，13，23：	1
9	Laparoscopic versus open surgery for rectal cancer : a meta-analysis 显示文摘	Aziz O Constantinides V Tekkis PP	2006	An Surg Oncol2006，13，3：	1
10	Laparoscopic versus open surgery for rectal cancer: a meta-analysis 显示文摘	Aziz O Constantinides V Tekkis PP	2006	Ann Surg Oncol2006，13，3：	1
11	Laparoscopic versus open surgery for rectal cancer:a mata-analysis显示文摘	Aziz O Constantinides V Tekkis PP	2006	Ann Surg Oncol2006，3，13：	1
12	The mammalian TRPC cat-ion channels显示文摘	VAZQUEZ G WEDEL B J AZIZ O	2004	Biochim Biophys Acta2004，1742，123：	1
13	Ingestion rate of postlarvae Peneeus monodon fed Apocyclops dengizicus and Artemia 显示文摘	Farhadian O Yusoff F M Aziz A	2007	Aquacuhure2007，269，：	1
14	Laparoscopic versus open surgery for rectal cancer:a meta-analysis显示文摘	AZIZ O CONSTANTINIDES V TEKKIS P P	2006	Ann Surg Oncol2006，13，3：	1
15	Laparoscopic versus open surgery for rectal cancer:a meta-analysis显示文摘	Aziz O Constantinides V Tekkis PP	2006	Ann Surg Oncol2006，13，3：	1
16	Laparoscopic surgery for colon can- cer显示文摘	Paraskeva PA Aziz O Darzi A	2005	Surg Clin North Am2005，85，1：	1
17	Evaluating operative risk in colorectal cancer surgery: ASA and POSSUM-based predictive models显示文摘	Al-Homoud S Purkayastha S Aziz O etal	2004	Surg Oneol2004，13，23：	1
18	Management of jejuna pouch dysfunction following total gastrectomy and Roux-en-Y reconstruction for gastric cancer:a case report显示文摘	Morar P Aziz O Holme TC	2012	Ann R Coll Surg Engl2012，94，3：	1
19	Laparoscopic versus open appendectomy in children:a meta-analysis显示文摘	Aziz O Athanasiou T Tekkis PP	2006	Ann Surg2006，243，1：	1
20	Single incision laparoscopic surgery for acute appendicitis:feasibility in pediatric patients 显示文摘	Chow A Aziz O Purkayastha S	2010	Diagn Ther Endosc2010，2010，29：	1

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