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| 1 | 胃癌预防亚太地区共识指南显示文摘背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽门螺杆菌(H.pylori)感染是非贲门胃腺癌必要但非充分的致病因子。盐的高摄入与胃癌强烈相关。新鲜果蔬对胃癌具有预防作用,但维生素和其他饮食补充并不能预防胃癌。H.pylori感染中的宿主-细菌相互作用导致不同类型的胃炎和胃酸分泌,从而决定疾病结局。胃癌阳性家族史是一个重要的危险因素。低血清胃蛋白酶原反映胃萎缩程度,可作为检出胃癌高危人群的标志物。H.pylori筛查和治疗被推荐作为减少高危人群胃癌危险性的一种策略,该策略在萎缩性胃炎发生前实施最为有效,但并不排除对胃癌高危人群的内镜监测。对胃癌低危人群不推荐行H.pylori筛查。H.pylori感染的一线治疗应遵循国家治疗指南。结论:高危人群中H.pylori筛查和根除策略可能会减少胃癌的发生率,本共识根据现有证据予以推荐。 | Kwong Ming Fock Nick Talley Paul Moayyedi Richard Hunt Takeshi Azuma Kentaro Sugano Shu Dong Xiao Shiu Kum Lam Khean Lee Goh Tsutomu Chiba Naomi Uemura Jae G Kim Nayoung Kim Tiing Leong Ang Varocha Mahachai Hazel Mitchell Abdul Aziz Rani Jyh Ming Liou Ratha-korn Vilaichone Jose Sollanor 钱本余 | 2008 | 胃肠病学2008，13，4： | 37 |
| 2 | IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients显示文摘AIM:To test whether the status of positive cytomegalovirus(CMV) DNA detection adds to the predictive value of IL28B and to further categorize C/T allele carriers.METHODS:This study included 166 chronic hepatitis C(CHC) patients who received combined interferon and ribavirin therapy for 48 wk,84 spontaneous hepatitis C virus(HCV) resolvers who were positive for IgG anti-HCV antibody and negative for HCV RNA,and 100 healthy subjects who were negative for both HCV antibodies and RNA as controls.Genomic DNA from peripheral blood was used for IL28B rs.12979860 single nucleotide polymorphism(SNP) and CMV DNA detection.A 139 bp fragment containing IL28B SNP was amplified in all subjects by polymerase chain reaction using a specifically designed primer.Then the IL28B rs.12979860 SNP was detected by restriction fragment length polymorphism(RFLP) genotyping.The presence of CMV DNA was tested by amplification of the gB1 gene using nested polymerase chain reaction.The role of CMV and IL28B rs.12979860 SNP genotypes in determining the response rate to combined interferon therapy and clinical status of patients were statistically analyzed.RESULTS:Current data showed that 67% of patients carrying the IL28B 12979860 C/C allele had a sustained viral response(SVR) while the genotypes C/T and TT were associated with lower SVR rates,50% and 48%,respectively.SVR rates for the C/C allele were lower than other HCV genotypes and/or other populations.Genotype CC was associated with the response to interferon(P = 0.025).Genotype C/C was reduced from 48% in controls to 14% in CHC patients suggesting its protective role against progression to chronicity.The majority of spontaneously cleared subjects(86%) were C/C,confirming its protective role.The C/T allele was present in 71% of CHC patients compared with 38% of controls,so the use of IL28B SNP genotyping only in these patients may be of little value as a predictor of response.CMV reactivation occurred in 40% of CHC patients.Co-infection with CMV seriously diminished the response to interferon(IFN) therapy,with SVR rates in C/C genotypes 87.5% in CMV-negative patients and 12.5% in CMV-positive patients(P < 0.0001).SVR rates among C/T carriers were reduced to < 50% in patients with positive CMV DNA while the non-response rate doubled.These data indicate that a supplemental assay for CMV viremia adds to the prognostic value of IL28B genotyping.CONCLUSION:The results suggest that both genetic(i.e.,spontaneous) and therapeutic(IFN-based therapy) arms are complementary in the battle against HCV.CMV DNA testing may be of value to better predict the response to IFN,particularly in IL28B C/T carriers. | Mostafa K El Awady Noha G Bader El Din Ashraf Tabll Yaser El Hosary Ashraf O Abdel Aziz Hesham El Khayat Mohsen Salama Tawfeek H Abdelhafez | 2013 | World Journal of Gastroenterology2013，19，2： | 8 |
| 3 | Bank predication:an investigation of cash flow based models 显示文摘 | Aziz Emanuel A D Lawson G | 1998 | Journal of Management Studies1998，，25： | 1 |
| 4 | A genetic epidemiological study of primary fallopian tube carcinoma显示文摘 | Aziz S Kuperstein G Rosen B | 2001 | Gynecol Oncol2001，80，3： | 1 |
| 5 | Bank prediction:an investigation of cash flow based models显示文摘 | EMANUEL D LAWSON G | 1988 | Journal of Management Studies1988，，25： | 1 |
| 6 | Exendin-4, a GLP-1 receptor agonist, interacts with proteins and their products of digestion to suppress food intake in rats 显示文摘 | Aziz A Anderson G H | 2003 | Nutritional Neurosciences Bull Exp Biol Med2003，135，6： | 1 |
| 7 | Optimizing the Performance of a Plug Flow System显示文摘 | Aziz Z B Klinzing G E | 1990 | Powder Technology1990，62，1： | 1 |
| 8 | c - Met is a prognos- tic markerand potential therapeutic target in clear cell renal cell carcinoma显示文摘 | GIBNEY G T AZIZ S A CAMP R L | 2013 | Ann Oncol2013，24，2： | 1 |
| 9 | Brain gut axis in health and disease显示文摘 | Aziz Q Thompson W G | 2004 | Gastroenterology2004，114，3： | 1 |
| 10 | Plug flow transport of cohesive coal:Horizontal and inclined flows 显示文摘 | Aziz Z B Klinzing G E | 1988 | Powder Technology1988，55，2： | 1 |
| 11 | Bank prediction:an investigation of cash flow based models显示文摘 | Aziz A D Emanuel G Lawson | 1988 | Journal of ManagementStudies1988，25，5： | 1 |
| 12 | The mammalian TRPC cat-ion channels显示文摘 | VAZQUEZ G WEDEL B J AZIZ O | 2004 | Biochim Biophys Acta2004，1742，123： | 1 |
| 13 | Pseudophacocoele following blunt? ocular? trauma显示文摘 | Aziz S Asokumaran T Intan G | 2011 | Med J Malaysia2011，66，1： | 1 |
| 14 | Incorporation of aminemoieties onto ultra-high molecular weight polyethylene(UHMWPE) surface via plasma and UV polymerizationof allylamine显示文摘 | Aziz G De Geyter N Declercq H | 2015 | Surf Coat Technol2015，15，： | 1 |
| 15 | Dense Phase Plug Flow Transfer: the 1-inch Horizontal Flow显示文摘 | Aziz Z B Klinzing G E | 1990 | Powder Technol1990，61，2： | 1 |
| 16 | EFNS guidelines on neurostimulation therapy for neuropathic pain显示文摘 | Cruccu G Aziz TZ Garcia-Larrea L | | 0，，09： | 1 |
| 17 | Pressure drop in wells producing oil and gas显示文摘 | Aziz K Govier G W Fogarasi M | 1972 | Journal of Canadian Petroleum Technology1972，11，3： | 1 |
| 18 | A genetic epidemiological study of carcinoma of the fallopian tube显示文摘 | Aziz S Kuperstein G Rosen B | 2001 | Gynecol 0ncol2001，80，3： | 1 |
| 19 | Comparison of robot-assisted versus conventional laparoscopic trans peritoneal pyeloplasty for patients with ureteropelvicJunction obstruction: a single-center study显示文摘 | Bird V G Leveillee RJ Eldefrawy A BrachoJ Aziz M S | 2011 | Urology2011，77，： | 1 |
| 20 | Pressure Drop in Wells Producing Oil and Gas显示文摘 | Aziz K Govier G W Fogarasi M | 1972 | JCPT1972，，： | 1 |
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