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您的检索式：作者名="Azali Azlan"
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| 1 | Argonaute:The executor of small RNA function显示文摘The discovery ot small non-coding RNAs- microRNA(miRNA),short interfering RNA(siRNA) and PIWIinteracting RNA(piRNA)- represents one of the most exciting frontiers in biology specifically on the mechanism of gene regulation.In order to execute their functions,these small RNAs require physical interactions with their protein partners,the Argonaute(AGO) family proteins.Over the years,numerous studies have made tremendous progress on understanding the roles of AGO in gene silencing in various organisms.In this review,we summarize recent progress of AGO-mediated gene silencing and other cellular processes in which AGO proteins have been implicated with a particular focus on progress made in flies,humans and other model organisms as compliment. | Azali Azlan Najat Dzaki Ghows Azzam | 2016 | Journal of Genetics and Genomics2016，43，8： | 10 |
| 2 | Identification and characterization of long noncoding RNAs and their association with acquisition of blood meal in Culex quinquefasciatus显示文摘The Southern house mosquito,Culex quinquefasciatus(Cx.quinquefasciatus)is an important vector that transmit multiple diseases including West Nile encephalitis,Japanese encephalitis,St.Louis encephalitis and lymphatic filariasis.Long noncoding RNAs(lncRNAs)involve in many biological processes such as development,infection,and virus–host interaction.However,there is no systematic identification and characterization of lncRNAs in Cx.quinquefasciatus.Here,we report the first lncRNA identification in Cx.quinquefasciatus.By using 31 public RNA-seq datasets,a total of 4763 novel lncRNA transcripts were identified,of which 3591,569,and 603 were intergenic,intronic,and antisense respectively.Examination of genomic features revealed that Cx.quinquefasciatus shared similar characteristics with other species such as short in length,low GC content,low sequence conservation,and low coding potential.Furthermore,compared to protein-coding genes,Cx.quinquefasciatus lncRNAs had lower expression values,and tended to be expressed in temporally specific fashion.In addition,weighted correlation network and functional annotation analyses showed that lncRNAs may have roles in blood meal acquisition of adult female Cx.quinquefasciatus mosquitoes.This study presents the first systematic identification and analysis of Cx.quinquefasciatus lncRNAs and their association with blood feeding.Results generated from this study will facilitate future investigation on the function of Cx.quinquefasciatus lncRNAs. | Azali Azlan Mardani Abdul Halim Faisal Mohamad Ghows Azzam | 2021 | Insect Science2021，28，4： | 0 |
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