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| 1 | 特级初榨橄榄油中酚类化合物不同提取方法对比研究显示文摘采用液液萃取法(LLE)、固相萃取法(SPE)和液液微萃取法(LLME)分别对特级初榨橄榄油中酚类成分进行提取,应用超高效液相色谱-高分辨质谱法(UPLC-HRMS)及Folin-Ciocalteus比色法分别进行酚类化合物组成研究和总酚含量测定,比较3种方法的提取效率。结果表明:特级初榨橄榄油中共检测到40种酚类化合物,其中液液萃取样品检出33种,固相萃取样品检出20种,液液微萃取样品检出15种,液液萃取法提取酚类化合物种类显著多于其他两种方法;液液萃取法提取的总酚含量分别为固相萃取法及液液微萃取法的2. 9倍和3. 7倍,液液萃取法对酚类化合物的提取效率明显优于其他两种方法;但从实验过程角度考量,液液微萃取法具有操作简单、省时省力、有机溶剂用量少、对实验人员伤害小、环境污染小等优点,具有进一步优化的潜力。 | 李雪 张玉 王君虹 朱作艺 李利 章国祥 关荣发 Ayton Jamie 李文 王伟 刘军 | 2020 | 中国油脂2020，45，1： | 5 |
| 2 | Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion显示文摘Ischemic stroke represents a significant danger to human beings,especially the elderly.Interventions are only available to remove the clot,and the mechanism of neuronal death during ischemic stroke is still in debate.Ferroptosis is increasingly appreciated as a mechanism of cell death after ischemia in various organs. | Qing-zhang Tuo Yu Liu Zheng Xiang Hong-Fa Yan Ting Zou Yang Shu Xu-long Ding Jin-jun Zou Shuo Xu Fei Tang Yan-qiu Gong Xiao-lan Li Yu-jie Guo Zhao-yue Zheng Ai-ping Deng Zhang-zhong Yang Wen-jing Li Shu-ting Zhang Scott Ayton Ashley I.Bush Heng Xu Lunzhi Dai Biao Dong Peng Lei | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 3 | Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis显示文摘While many drugs are effective at reducing the relapse frequency of multiple sclerosis (MS), there is an unmet need for treatments that slow neurodegeneration resulting from secondary disease progression. The mechanism of neurodegeneration in MS has not yet been established. Here, we discovered a potential pathogenetic role of ferroptosis, an iron-dependent regulated cell death mechanism, in MS. We found that critical ferroptosis proteins (acyl-CoA synthetase long-chain family member 4, ACSL4) were altered in an existing genomic database of MS patients, and biochemical features of ferroptosis, including lipid reactive oxygen species (ROS) accumulation and mitochondrial shrinkage, were observed in the experimental autoimmune encephalitis (EAE) mouse model. Targeting ferroptosis with ferroptosis inhibitors or reducing ACSL4 expression improved the behavioral phenotypes of EAE mice, reduced neuroinflammation, and prevented neuronal death. We found that ferroptosis was an early event in EAE, which may promote T-cell activation through T-cell receptor (TCR) signaling in vitro and in vivo. These data indicate that ferroptosis may be a potential target for treating MS. | Jinyuan Luoqian Wenyong Yang Xulong Ding Qing-zhang Tuo Zheng Xiang Zhaoyue Zheng Yu-jie Guo Li Li Pengbo Guan Scott Ayton Biao Dong Huiyuan Zhang Hongbo Hu Peng Lei | 2022 | Cellular & Molecular Immunology2022，19，8： | 2 |
| 4 | Endometrial and vaginal effects of low-dose estradiol delivered by vaginal ring or vaginal tablet 显示文摘 | Weisberg E Ayton R Darlin G | 2005 | Climacteric2005，8，1： | 1 |
| 5 | CPPA oxygen delignifieation survey 显示文摘 | Reid D W Ayton J Mullen T | 1998 | Pulp and Paper Canada1998，99，11： | 1 |
| 6 | Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins显示文摘 | Ayton P M Cleary M L | 2001 | Oncogene2001，20，40： | 1 |
| 7 | The role of intravenous contrast enhancement in magnetic resonance imaging of prostatic carcinoma显示文摘 | Brown G Macvicar DA Ayton V | 1995 | Clin Radiol1995，50，9： | 1 |
| 8 | Developmental eye movement test What is it Really Measuring? 显示文摘 | Ayton LN Abel LA Fricke TR | 2009 | Optom Vis Sci2009，86，： | 1 |
| 9 | Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins 显示文摘 | Ayton PM Cleary ML | 2001 | Oncogene2001，20，40： | 1 |
| 10 | Predicting negative mood state and personal growth in African American and White long-term breast cancer survivors显示文摘 | Porter LS C|ayton MF Belyea M | 2006 | Ann Behav Med2006，31，3： | 1 |
| 11 | Differential expression of the topoisomerase Ⅱ α and 13 genes in human breast cancers 显示文摘 | Sandri MI Hochhauser D Ayton P | 1996 | Br J Cancer1996，73，： | 1 |
| 12 | Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease显示文摘 | Ayton S Lei P Duce JA | 2013 | Ann Neu- rol2013，73，4： | 1 |
| 13 | A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL显示文摘 | DiMartino J F Miller T Ayton P M | 2000 | Blood2000，96，2： | 1 |
| 14 | A delicate balance: Iron metabolism and diseases of the brain显示文摘 | Hare D Ayton S Bush A | 2013 | Front Aging Neu- rosci2013，5，8： | 1 |
| 15 | The Role of Intravenous Contrast Enhancement in Magnetic Resonance Imaging of Prostatic Carcinoma显示文摘 | Brown G Macvicar DA Ayton V | 1995 | Clin Radiol1995，50，9： | 1 |
| 16 | Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias显示文摘 | So C W Lin M Ayton P M | 2003 | Cancer Cell2003，4，2： | 1 |
| 17 | A delicate balance: Iron metabolism and diseases of the brain 显示文摘 | Hare D Ayton S Bush A | 2013 | Front Aging Neurosci2013，5，： | 1 |
| 18 | Optical coherence tomography-guided retinal prosthe- sis design: model of degenerated retinal curvature and thickness for patient-specific devices显示文摘 | Nicholas L Opie Lauren N Ayton Nicholas V Apollo | 2014 | Health science2014，38，6： | 1 |
| 19 | Differential expression of the topoisomerase 11αand β genes in human breast cancers 显示文摘 | Sandri MI Hochhauser D Ayton P | 1996 | Br J Cancer1996，73，： | 1 |
| 20 | Differential expression of the topoisomerase Ⅱα and β genes in human breast cancers 显示文摘 | Sandri MI Hochhauser D Ayton P | 1996 | Br J Cancer1996，73，： | 1 |
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