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| 1 | Solid pseudopapillary neoplasm of the pancreas显示文摘Solid pseudopapillary neoplasms are rare.This article reviews the clinical and pathologic features of solid pseudopapillary neoplasm of the pancreas,including the epidemiology,cytology,molecular pathology,differential diagnosis,treatment,and prognosis.Solid pseudopapillary neoplasms are low-grade malignant tumours of the pancreas characterized by poorly cohesive epithelial cells with solid and pseudopapillary patterns.Solid pseudopapillary neoplasms occur predominantly in young women.Although solid pseudopapillary neoplasms can occur throughout the pancreas,they arise slightly more frequently in the tail of the pancreas.The aetiology is unknown.Extremely rare cases have been reported in the setting of familial adenomatous polyposis.There are no symptoms unique to solid pseudopapillary neoplasms,however,the most common symptom is abdominal pain or discomfort.The features of solid pseudopapillary neoplasms on computed tomography imaging are indicative of the pathologic changes within the tumour.Typically,well-demarcated masses with variably solid and cystic appearances.Microscopically,these tumours are composed of epithelial cells forming solid and pseudopapillary structures,frequently undergoing haemorrhagic cystic degeneration.Typically,these tumours express nuclear and/or cytoplasmicβ-catenin.Almost all solid pseudopapillary neoplasms harbour mutations in exon 3 of CTNNB1,the gene encodingβ-catenin.The overall prognosis is excellent,and most patients are cured by complete surgical resection. | Ayo O Omiyale | 2021 | World Journal of Hepatology2021，13，8： | 8 |
| 2 | Adult pancreatoblastoma: Current concepts in pathology显示文摘Adult pancreatoblastoma is an exceptionally rare malignant tumour of the pancreas that mimics other solid cellular neoplasms of the pancreas,which may pose diagnostic difficulties.Because of its rarity,little is known about its clinical and pathologic features.This article reviews the clinical and pathologic features of pancreatoblastoma in adults including differential diagnosis,treatment,and follow-up.Although pancreatoblastoma commonly occurs in childhood,there have now been more than 70 adult pancreatoblastomas described in the literature.There is a slight male predominance.There are no symptoms unique to pancreatoblastomas and adult patients are frequently symptomatic.The most common presenting symptom is abdominal pain.Grossly,the tumours are often large and well-circumscribed.Microscopically,pancreatoblastomas are composed of neoplastic cells with predominantly acinar differentiation and characteristic squamoid nests.These tumours are positive for trypsin,chymotrypsin,lipase,and BCL10.Loss of heterozygosity on chromosome 11p is the most common molecular alteration in pancreatoblastomas.Adult pancreatoblastomas are aggressive tumours with frequent local invasion,recurrence,and distant metastasis.Treatment consists of surgical resection.Chemotherapy and radiotherapy may have a role in the treatment of recurrent,residual,unresectable,and metastatic disease.It is important to distinguish pancreatoblastomas from morphological mimics such as acinar cell carcinomas,solid pseudopapillary neoplasms,and pancreatic neuroendocrine neoplasms. | Ayo O Omiyale | 2021 | World Journal of Gastroenterology2021，27，26： | 5 |
| 3 | Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats显示文摘Objective:To evaluate the alleviating effects of melatonin on oxidative changes in the testes and pituitary gland induced by subacute chlopyrifos(CPF) exposure in rats.Methods:Forty adult male Wistar rats divided into 4 groups of 10 animals were used for the study.Croup I received soya oil(2 mL/kg) while group II was administered with melatonin(0.5 mg/kg).Group III was administered CPF only(8.5 mg/kg l/10th of the LD50) while group Ⅳ was pretreated with melatonin(0.5 mg/kg) and then exposed to CPF(8.5 mg/kg),10 min later.The regimens were administered by gavage once daily for a period of 28 d.At the end of the exposure period, the rats were sacrificed and the testicular tissues and pituitary glands were evaluated for the malonaldehyde(MDA) concentration and activities of superoxide dismutase(SOD) and catalase(CAT).Results:CPF increased MDA concentrations and reduced the activities of SOD and CAT in the testes and pituitary gland.Melatonin pretreatment reduced the testicular and pituitary MDA concentrations and improves the SOD and CAT activities.Conclusions:the study showed that subacute CPF-induced oxidative stress in the testes and pituitary glands were alleviated by melatonin due to its antioxidant property. | Angela J Umosen Suleiman F Ambali Joseph O Ayo Bisala Mohammed Chidiebere Uchendu | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 5 |
| 4 | Towards the Tipping Point for FAIR Implementation显示文摘This article explores the global implementation of the FAIR Guiding Principles for scientific management and data stewardship,which provide that data should be findable,accessible,interoperable and reusable.The implementation of these principles is designed to lead to the stewardship of data as FAIR digital objects and the establishment of the Internet of FAIR Data and Services(IFDS).If implementation reaches a tipping point,IFDS has the potential to revolutionize how data is managed by making machine and human readable data discoverable for reuse.Accordingly,this article examines the expansion of the implementation of FAIR Guiding Principles,especially how and in which geographies(locations)and areas(topic domains)implementation is taking place.A literature review of academic articles published between 2016 and 2019 on the use of FAIR Guiding Principles is presented.The investigation also includes an analysis of the domains in the IFDS Implementation Networks(INs).Its uptake has been mainly in the Western hemisphere.The investigation found that implementation of FAIR Guiding Principles has taken firm hold in the domain of bio and natural sciences.To achieve a tipping point for FAIR implementation,it is now time to ensure the inclusion of non-European ascendants and of other scientific domains.Apart from equal opportunity and genuine global partnership issues,a permanent European bias poses challenges with regard to the representativeness and validity of data and could limit the potential of IFDS to reach across continental boundaries.The article concludes that,despite efforts to be inclusive,acceptance of the FAIR Guiding Principles and IFDS in different scientific communities is limited and there is a need to act now to prevent dampening of the momentum in the development and implementation of the IFDS.It is further concluded that policy entrepreneurs and the GO FAIR INs may contribute to making the FAIR Guiding Principles more flexible in including different research epistemologies,especially through its GO CHANGE pillar. | Mirjam van Reisen Mia Stokmans Mariam Basajja Antony Otieno Ong’ayo Christine Kirkpatrick Barend Mons | 2020 | Data Intelligence2020，2，1： | 3 |
| 5 | Primary vascular tumours of the kidney显示文摘Primary vascular tumours of the kidney are rare and may pose diagnostic difficulties because of their similar clinical,morphological,and immunohistochemical features.This article summarizes the clinical and pathological features of primary renal angiosarcoma and anastomosing haemangioma of the kidney including epidemiology,genetics,and prognosis.Renal anastomosing haemangiomas are benign neoplasms characterized by anastomosing capillary-sized vascular channels.These tumours are rare,with about 75 cases reported in the literature.Most anastomosing haemangiomas are found incidentally on ultrasound,computed tomography,or magnetic resonance imaging.Common symptoms include abdominal pain,haematuria,and abdominal mass.Renal anastomosing haemangiomas are characterized by recurrent mutations in GNAQ and GNA14 genes.The prognosis of anastomosing haemangioma is excellent.Primary renal angiosarcomas are malignant tumours showing endothelial differentiation.To date,76 cases have been described in the literature.Primary renal angiosarcomas are frequently symptomatic.The clinical features of renal angiosarcomas are similar to those of renal anastomosing haemangiomas,including abdominal pain,haematuria,and abdominal mass.Angiogenesis-related genes and vascular-specific receptor tyrosine kinases such as KDR,TIE1,SNRK,TEK,and FLT1 are upregulated in angiosarcomas.Primary renal angiosarcomas are highly aggressive neoplasms with a poor prognosis despite surgical treatment,chemotherapy,radiotherapy,or targeted therapy. | Ayo O Omiyale | 2021 | World Journal of Clinical Oncology2021，12，12： | 2 |
| 6 | FAIR Practices in Africa显示文摘This article investigates expansion of the Internet of FAIR Data and Services(IFDS)to Africa,through the three GO FAIR pillars:GO CHANGE,GO BUILD and GO TRAIN.Introduction of the IFDS in Africa has a focus on digital health.Two examples of introducing FAIR are compared:a regional initiative for digital health by governments in the East Africa Community(EAC)and an initiative by a local health provider(Solidarmed)in collaboration with Great Zimbabwe University in Zimbabwe.The obstacles to introducing FAIR are identified as underrepresentation of data from Africa in IFDS at this moment,the lack of explicit recognition of situational context of research in FAIR at present and the lack of acceptability of FAIR as a foreign and European invention which affects acceptance.It is envisaged that FAIR has an important contribution to solve fragmentation in digital health in Africa,and that any obstacles concerning African participation,context relevance and acceptance of IFDS need to be removed.This will require involvement of African researchers and ICT-developers so that it is driven by local ownership.Assessment of ecological validity in FAIR principles would ensure that the context specificity of research is reflected in the FAIR principles.This will help enhance the acceptance of the FAIR Guidelines in Africa and will help strengthen digital health research and services. | Mirjam van Reisen Mia Stokmans Munyaradzi Mawere Mariam Basajja Antony Otieno Ong’ayo Primrose Nakazibwe Christine Kirkpatrick Kudakwashe Chindoza | 2020 | Data Intelligence2020，2，1： | 2 |
| 7 | High glucose causes an increase in extracellular matrix proteins in cultured mesangial cells 显示文摘 | Ayo S H Radnik R A Garoni J A | 1990 | Am J Pathol1990，136，6： | 1 |
| 8 | Does dexmedetomidine reduce the injection pain due to propofol and rocuronium显示文摘 | Ayo?lu H Altunkaya H Ozer Y | | 0，，6： | 1 |
| 9 | High glucose increase diacylglycerol mass and activates protein kinase C in mesangial cell culture显示文摘 | Ayo SH Radpik R Caroni JA | 1991 | AMJ Physiol1991，261，： | 1 |
| 10 | Assessment of thermal load on trans- ported goats administered with ascorbic acid during the hot- dry eonditions显示文摘 | Minka N S Ayo G O | 2012 | International Journal of Biometeorol2012，56，2： | 1 |
| 11 | High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures显示文摘 | Ayo SH Radnik R Garoni JA | 1991 | Am J Physiol1991，261，42： | 1 |
| 12 | Microbial transglutaminase and caseinate as cold set binders: Influence of meat species and chilling storage显示文摘 | Carballo J Ayo J Colmenero F J | 2006 | LWT-Food Science and Technology2006，39，6： | 1 |
| 13 | The glomerula rmesangium in diabetesmellitus显示文摘 | Kreisberg JI Ayo SH | 1993 | Kidney Int1993，43，1： | 1 |
| 14 | Taxol inhibits progression of congen-ital polycystic kidney disease显示文摘 | Woo D D L Miao S Y P Pel ayo J C | 1994 | Nature1994，368，： | 1 |
| 15 | Characteristics of meat batters with added native and preheated defatted walnut 显示文摘 | S Cofrades A Serrano J Ayo | 2008 | Food Chemistry2008，107，： | 1 |
| 16 | Comparison of rates of flagellate bacterivory and bacterial production in a marine coastal system显示文摘 | BARCONA I AYO B UNANUE M | 1992 | Appl Environ Microbiol1992，58，12： | 1 |
| 17 | Fusion of face and speech data for person identity verification 显示文摘 | BEN-YACOUB S A BDELJAOUED Y M AYO RAN E | 1999 | IEEE Trans on Neural Networks1999，10，5： | 1 |
| 18 | Prevalence and risk factors for sexually transmitted infections in a high-risk occupational group:the case of fishermen along Lake Victoria in Kisumu,Kenya显示文摘 | Kwena ZA Bukusi EA Ng'ayo MO | 2010 | Int J STD AIDS2010，21，10： | 1 |
| 19 | High glucose causes an increase in extraeellular matrix proteins in cultured mesangial cells显示文摘 | Ayo S Radnik R Garoni J | 1990 | Am J Pathol1990，136，： | 1 |
| 20 | Increased extracellular matrix synthesisand mRNA in mesangial cells grown in high glucose medium显示文摘 | Ayo SH Rednik RA Class WF II | 1990 | Am JPhysiol1990，260，： | 1 |
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