|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment显示文摘In patients with inflammatory bowel disease(IBD), chronic inflammation is a major risk factor for the development of gastrointestinal malignancies. The pathogenesis of colitis-associated cancer is distinct from sporadic colorectal carcinoma and the critical molecular mechanisms underlying this process have yet to be elucidated. Patients with IBD have also been shown to be at increased risk of developing extra-intestinal malignancies. Medical therapies that diminish the mucosal inflammatory response represent the foundation of treatment in IBD, and recent evidence supports their introduction earlier in the disease course. However, therapies that alter the immune system, often used for long durations, may also promote carcinogenesis. As the population of patients with IBD grows older, with longer duration of chronic inflammation and longer exposure to immunosuppression, there is an increasing risk of cancer development. Many of these patients will require cancer treatment, including chemotherapy, radiation, hormonal therapy, and surgery. Many patients will require further treatment for their IBD. This review seeks to explore the characteristics and risks of cancer in patients with IBD, and to evaluate the limited data on patients with IBD and cancer, including management of IBD after a diagnosis of cancer, the effects of cancer treatment on IBD, and the effect of IBD and medications for IBD on cancer outcomes. | Jordan E Axelrad Simon Lichtiger Vijay Yajnik | 2016 | World Journal of Gastroenterology2016，22，20： | 33 |
| 2 | Thiopurines and inflammatory bowel disease: Current evidence and a historical perspective显示文摘The use of thiopurines in inflammatory bowel disease(IBD) has been examined in numerous prospective, controlled trials, with a majority demonstrating a clinical benefit. We conducted this review to describe the historical and current evidence in the use of thiopurines in IBD. A systematic search was performed on MEDLINE between 1965 and 2016 to identify studies on thiopurines in IBD. The most robust evidence for thiopurines in IBD includes induction of remission in combination with anti-tumor necrosis factor(antiTNF) agents, and maintenance of remission and postoperative maintenance in Crohn's disease. Less evidence exists for thiopurine monotherapy in induction of remission, maintenance of ulcerative colitis, chemoprevention of colorectal cancer, and in preventing immunogenicity to anti-TNF. Evidence was often limited by trial design. Overall, thiopurines have demonstrated efficacy in a broad range of presentations of IBD. With more efficacious novel therapeutic agents, the positioning of thiopurines in the management of IBD will change and future studies will analyze the benefit of thiopurines alone and in conjunction with these new medications. | Jordan E Axelrad Abhik Roy Garrett Lawlor Burton Korelitz Simon Lichtiger | 2016 | World Journal of Gastroenterology2016，22，46： | 3 |
| 3 | Application of interference cancel lation to the GPS near-far problem 显示文摘 | P Madhani P Axelrad | 2003 | IEEE Transactions on Aerospace and Electronic Systems2003，39，2： | 1 |
| 4 | Electrical inhibition of Purkinje cells in the cerebellum of the rat显示文摘 | Korn H Axelrad H | | 0，，： | 1 |
| 5 | Assessing sex assignmentconcordance with genotype and phenotype 显示文摘 | Suresh D Crawford J Axelrad ME | 2013 | Int J Pediatr En-docrinol2013，2013，1： | 1 |
| 6 | Adaptive SNR -based carrier phase muhipath mitigation technique显示文摘 | Comp C J Axelrad P | 1998 | Trans Aerosp Electron Syst1998，34，26： | 1 |
| 7 | Autonomous GPS integrity monitoring using the pseudorange residual显示文摘 | PARKINSON B W AXELRAD P | 1988 | NAVIGATION Journal of the Institute of Navigation1988，35，1： | 1 |
| 8 | Spacecraft Attitude Estima- tion Using the Global Positioning System: Method- ology and Results for RADCAL显示文摘 | Axelrad P Ward L M | 1996 | Journal of Guidance Control and Dynamics1996，19，： | 1 |
| 9 | Treatment of the Stress Positive Ligamentous SE4 Ankle Fracture: Incidence of Syndesmotic Injury and Clinical Decision Making显示文摘 | Paul Tornetta Thomas W. Axelrad Tarek A. Sibai William R. Creevy | 2012 | Journal of Orthopaedic Trauma2012，，： | 1 |
| 10 | Use of clinical assessment tools in the evaluation of fracture healing显示文摘 | Axelrad TW Einhorn TA | 2011 | Injury2011，42，3： | 1 |
| 11 | Mercury Monitoring 显示文摘 | Atkeson T Axelrad D | 2004 | Research and Environmental Assessment2004，37，9： | 1 |
| 12 | Restoring an Acoustic Source from Pressure Data Using Wiener Filtering显示文摘 | Fleischer H Axelrad U | 1986 | Acoustical Society of America1986，60，2： | 1 |
| 13 | An Adaptive SNR-based Carrier Phase Multipath Mitigation Technique显示文摘 | Comp C J Axelrad P | 1998 | Trans on Aerospace and Electronic Systems1998，34，1： | 1 |
| 14 | Initial results of land-reflected GPS bistatic radar measurements in SMEX02显示文摘 | MASTERS D AXELRAD P KATZBERG S | 2004 | Remote Sensing of Environment2004，，92： | 1 |
| 15 | Improving the Pecision of High-rate GPS显示文摘 | LARSON K M BILICH A AXELRAD P | 2007 | Journal of Geophysical Research:Solid Earth(1978-2012)2007，112，05422： | 1 |
| 16 | New technologies for the onhaneement of skeletal repair显示文摘 | Kakar S Einhom TA | 2007 | Injury2007，，： | 1 |
| 17 | Autonomous GPS Integrity Monitoring Using the Pseudorange Residual 显示文摘 | Bradford W Parkinson Penina Axelrad | 1988 | Journal of the Institute of Navigation1988，35，2： | 1 |
| 18 | Initial resuhs of land-reflected GPS biostatic radar measurements in SMEX02 显示文摘 | Masters D Axelrad P Katzberg S | 2004 | Remote Sensingof Environment2004，92，4： | 1 |
| 19 | Heterotopic ossifica-tion after the use of commercially available recombinant humanbone morphogenetic proteins in four patients显示文摘 | Axelrad TW Steen B Lowenberg DW | 2008 | J Bone Joint SurgBr2008，90，12： | 1 |
| 20 | SNR BasedMultipath Error Correction for GPS Differential Phase显示文摘 | AXELRAD P COMP C J MACDORAN P F | 1996 | IEEE Transaction on Aerospace&Electronic Sys-tems1996，32，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员