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| 1 | Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice显示文摘Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization.Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone. | Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas | 2017 | Bone Research2017，5，2： | 3 |
| 2 | Studies on inducing mutations in bougainvillea显示文摘 | Abd EI-Mageid y A Awad A E | 2009 | Zagazig Journal of Agricultural Research2009，，： | 1 |
| 3 | Optimal control of the genital herpes epidemic显示文摘 | | 2001 | Chaos Solitons and Fractals2001，12，： | 1 |
| 4 | Optimal control and synchronization of Lotka-volterra model显示文摘 | YASSEN M T | 2001 | Chaos Solitons and Fractals2001，12，： | 1 |
| 5 | Echinococcosis (zoonotic hydatidosis) in street dogs in urban and rural areas,Dakahlia Governorate, Egypt显示文摘 | Elshazly A M Awad S E Abdel Tawab A H | 2007 | J Egypt Soc Parasitol2007，37，1： | 1 |
| 6 | Exponential Control of a Rotational Motion of a Rigid Body Using Quaternions显示文摘 | Awad E L G Elazab E R | 2003 | Applied Mathematics and Computation2003，137，2： | 1 |
| 7 | Effect of light on flavonoid and chloragenic acid level in the skin of Jonagold apples 显示文摘 | Awad M A Wagenmakers P S Jager A D E | 2001 | Sci Hort2001，88，4： | 1 |
| 8 | Deltame- thrin-induced oxidative damage and biochemical alterations in rat and its attenuation by Vitamin E 显示文摘 | Yousef M I Awad T I Mohameda E H | 2006 | Toxicology2006，227，： | 1 |
| 9 | De- termining the coping strategies of individuals with epilepsy 显示文摘 | Bautista R E Rundle-Gonzalez V Awad R G | 2013 | Epilepsy Behav2013，27，2： | 1 |
| 10 | Chaos and adaptive control in two preys, one predator system with nonlinear feedback 显示文摘 | Awad E G Alruzaiza A S | 2007 | Chaos Solitons and Fraetals (S0960-0779)2007，34，2： | 1 |
| 11 | Biology of vascular malformations of the brain显示文摘 | Leblanc GG Golanov E Awad IA | 2009 | Stroke2009，40，12： | 1 |
| 12 | In vitro inacti- vation of two Egyptian A/H5 N1 viruses by four commercial chem- ical disinfectants显示文摘 | Marzouk E Abd E1-Hamid HS Awad AM et at | 2014 | Avian Dis2014，58，3： | 1 |
| 13 | Preliminary studies of a newly developed subunit vaccine for channel cat- fish virus disease 显示文摘 | AWAD M A NUSBAUM K E BRADY Y J | 1989 | Journal of Aquatic Animal Health1989，1，7： | 1 |
| 14 | Peroxisomal enzymes and 8-hydroxydeoxyguanosine in rat liver treated with perfluorooctanoic acid显示文摘 | Abdellatif A Al-Tonsy A H Awad M E | | 0，，01： | 1 |
| 15 | Influence of self-healing, mixing method and adding silica fume on mechanical properties of recycled aggregates concrete 显示文摘 | Elhakam A A Mohamed A E Awad E | 2012 | Construction and Building Materials2012，，： | 1 |
| 16 | Hypoxia and interleukin-1 beta stimulate vascular endothelial growth factor production in human proximal tubular cells显示文摘 | EL AWAD B KREFT B WOLBER E M | 2000 | Kidney Int2000，58，1： | 1 |
| 17 | CD34+ blood cells accelerate vascularization and healing of diabetic mouse skin wounds显示文摘 | Sivan Loukianova E Awad OA Stepanovic V | 2003 | J Vase Res2003，40，： | 1 |
| 18 | Comparing the ef- ficacy of mandibular implant-retained over dentures and conventional dentures among middle-aged edentulous pa- tients: satisfaction and functional assessment 显示文摘 | Awad MA Lurid JP Dufresne E | 2003 | Int J Prosthodont2003，16，2： | 1 |
| 19 | Effect of addition of a probiotic microorganism to'broiler diets contaminated with deoxynivalenol on performance and histological alterations of in- testinal villi of broiler chickens显示文摘 | Awad W A Bohm J Razzazi-Fazeli E | 2006 | Poultry Science2006，85，6： | 1 |
| 20 | DSG2 mutations contribute to arrhythmogenic fight ventricular dysplasia/cardiomyopathy 显示文摘 | Awad MM Dalal D Cho E | 2006 | Am J Hum Genet2006，79，1： | 1 |
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