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| 1 | 血管瘤联盟:脑海绵状血管畸形临床管理指南2017显示文摘2017年5月,血管瘤联盟科学顾问委员会临床专家小组(Angioma Alliance Scientific Advisory Board Clinical Experts Panel)在Neurosurgery杂志上发布了《脑海绵状血管畸形临床管理指南》,现在摘录如下。1基因测定和咨询首次脑海绵状血管畸形(cerebral cavernous malformations,CCM)时, | 杨中华 AKERS A AL-SHAHI SALMAN R A AWAD I | 2017 | 中国卒中杂志2017，12，8： | 28 |
| 2 | Neurogenic bowel dysfunction in patients with spinal cord injury, myelomeningocele, multiple sclerosis and Parkinson’s disease显示文摘Exciting new features have been described concerning neurogenic bowel dysfunction,including interactions between the central nervous system,the enteric nervous system,axonal injury,neuronal loss,neurotransmission of noxious and non-noxious stimuli,and the fields of gastroenterology and neurology.Patients with spinal cord injury,myelomeningocele,multiple sclerosis and Parkinson's disease present with serious upper and lower bowel dysfunctions characterized by constipation,incontinence,gastrointestinal motor dysfunction and altered visceral sensitivity.Spinal cord injury is associated with severe autonomic dysfunction,and bowel dysfunction is a major physical and psychological burden for these patients.An adult myelomeningocele patient commonly has multiple problems reflecting the multisystemic nature of the disease.Multiple sclerosis is a neurodegenerative disorder in which axonal injury,neuronal loss,and atrophy of the central nervous system can lead to permanent neurological damage and clinical disability.Parkinson's disease is a multisystem disorder involving dopaminergic,noradrenergic,serotoninergic and cholinergic systems,characterizedby motor and non-motor symptoms.Parkinson's disease affects several neuronal structures outside the substantia nigra,among which is the enteric nervous system.Recent reports have shown that the lesions in the enteric nervous system occur in very early stages of the disease,even before the involvement of the central nervous system.This has led to the postulation that the enteric nervous system could be critical in the pathophysiology of Parkinson's disease,as it could represent the point of entry for a putative environmental factor to initiate the pathological process.This review covers the data related to the etiology,epidemiology,clinical expression,pathophysiology,genetic aspects,gastrointestinal motor dysfunction,visceral sensitivity,management,prevention and prognosis of neurogenic bowel dysfunction patients with these neurological diseases.Embryological,morphological and experimental studies on animal models and humans are also taken into account. | Richard A Awad | 2011 | World Journal of Gastroenterology2011，17，46： | 20 |
| 3 | Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice显示文摘Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization.Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone. | Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas | 2017 | Bone Research2017，5，2： | 3 |
| 4 | Rectal tone and compliance affected in patients with fecal incontinence after fistulotomy显示文摘AIM: To investigate the anal sphincter and rectal factors that may be involved in fecal incontinence that develops following fistulotomy(FIAF).METHODS: Eleven patients with FIAF were compared with 11 patients with idiopathic fecal incontinence and with 11 asymptomatic healthy subjects(HS). All of the study participants underwent anorectal manometry and a barostat study(rectal sensitivity, tone, compliance and capacity). The mean time since surgery was 28 ± 26 mo. The postoperative continence score was 14 ± 2.5(95%CI: 12.4-15.5, St Mark's fecal incontinence grading system).RESULTS: Compared with the HS, the FIAF patients showed increased rectal tone(42.63 ± 27.69 vs 103.5 ± 51.13, P = 0.002) and less rectal compliance(4.95 ± 3.43 vs 11.77 ± 6.9, P = 0.009). No significant differences were found between the FIAF patients and the HS with respect to the rectal capacity; thresholds for the non-noxious stimuli of first sensation, gas sensation and urge-to-defecate sensation or the noxious stimulus of pain; anal resting pressure or squeeze pressure; or the frequency or percentage of relaxation of the rectoanal inhibitory reflex. No significant differences were found between the FIAF patients and the patients with idiopathic fecal incontinence.CONCLUSION: In patients with FIAF, normal motor anal sphincter function and rectal sensitivity are preserved, but rectal tone and compliance are impaired. The results suggest that FIAF is not due to alterations in rectal sensitivity and that the rectum is more involved than the anal sphincters in the genesis of FIAF. | Richard Alexander Awad Santiago Camacho Francisco Flores Evelyn Altamirano Mario Antonio García | 2015 | World Journal of Gastroenterology2015，21，13： | 3 |
| 5 | In vitro and in vivo effects of ferulic acid on gastrointestinal motility:Inhibition of cisplatin-induced delay in gastric emptying in rats显示文摘AIM: To study the effects of ferulic acid on gastrointe-stinal motility both in vitro and in vivo.METHODS: Ferulic acid induced concentration-dependent stimulation of the basal tone of isolated guinea pig ileum (2-20 μmol/L) and isolated rat fundus (0.05-0.4 mmol/L). RESULTS: Ferulic acid significantly accelerated the gastrointestinal transit and gastric emptying in rats in a dose-dependent manner (50-200 mg/kg, po). Cisplatin (2.5-20 mg/kg, ip) induced a dose-dependent delay in gastric emptying in rats. Pretreatment with ferulic acid dose-dependently, significantly reversed the cisplatin-induced delay in gastric emptying. CONCLUSION: The endogenous prostaglandins (PGs) are involved in mediating the stimulant effects of ferulic acid. This effect of dietary ferulic acid may help improve other accompanying gastrointestinal symptoms such as abdominal discomfort and also may protect against emesis induced by cytotoxic drugs. | Osama A Badary Azza S Awad Mohey A Sherief Farid MA Hamada | 2006 | World Journal of Gastroenterology2006，12，33： | 2 |
| 6 | On egg fractionation: applications of liquid chromatography to the isolation and the purification of hen egg white and egg yolk proteins显示文摘 | AWADE A C | 1996 | Zeitschrift fUr Lebensmitteluntersuchung und Forschung A1996，202，1： | 1 |
| 7 | On the Voltage Mirrors and the Current Mirrors显示文摘 | Awad I A Soliman A M | 2002 | Analog Integrated Circuits and Signal Processing2002，32，： | 1 |
| 8 | New CMOS realization of the CCII- 显示文摘 | I A Awad A M Soliman | 1999 | IEEE transaction on circuits and systems-Ⅱ: Analog and digital signal processing1999，46，4： | 1 |
| 9 | Relationships between fruit nutrients and concentration of flavonoids and chlorogenic acid in Elstar apple skin显示文摘 | AWAD M A de JAGER A | 2002 | Sci Hortic2002，92，34： | 1 |
| 10 | Effect of β-sitosterol, a plant sterol, on growth, protein phosphatase 2A and phospholipida D in LNCaP cells显示文摘 | Awad A B Gan Y Fink C S | 2000 | Nutr Cancer2000，36，： | 1 |
| 11 | Vascular endothelial growth factor level in chronic liver diseases 显示文摘 | Makhlouf MM Awad A Zakhari MM | 2002 | J Egypt Soc Parasitol2002，32，： | 1 |
| 12 | Control strategies for Campylobacter infection in poultry production 显示文摘 | Ghareeb K Awad W A Mohnl M | 2013 | World''s Poultry Science Journal2013，69，1： | 1 |
| 13 | Validation of the comprehensive international classification of functioning,disability and health core set for diabetes mellitus:Physical therapists'perspectives显示文摘 | Awad H Alghadir A | 2013 | American Journal of Physical Medicine and Rehabilitation2013，92，11： | 1 |
| 14 | Effects of Transportation on Stress and Fear Responses of Growing Broilers Supplemented with Prebiotic or Probiotic显示文摘 | Ghareeb K Awad W A Nitsch S | 2008 | Poult Sci2008，7，7： | 1 |
| 15 | Genotoxic effects of deoxynivalenol in broiler chickens fed with low protein diets 显示文摘 | Awad W A Ghareeb K Dadak A etal | 2012 | Poult Sci2012，91，： | 1 |
| 16 | Flavonoid and chlorogenic acid levels in apple fruit: charactererisation of variation显示文摘 | AWAD M A JAGER A D WESTIN L M | 2000 | Sci Hort2000，83，： | 1 |
| 17 | Multicomponent image segmentation: a comparative analysis between a hybrid genetic algorithm and self-organizing maps 显示文摘 | AWAD M M CHEHDI K NASRI A | 2009 | Int J Remote Sens2009，30，3： | 1 |
| 18 | Changes in B-type natriuretic peptide levels in hemodialysis and the effect of depressed left ventricular function显示文摘 | Safley DM Awad A Sullivan RA | 2005 | Adv Chronic Kidney Dis2005，12，： | 1 |
| 19 | A novel sine-wave generator using a single operational amplifier显示文摘 | SOLIMAN A M AWAD S S | 1978 | Proceedings of the IEEE1978，66，2： | 1 |
| 20 | Studies on inducing mutations in bougainvillea显示文摘 | Abd EI-Mageid y A Awad A E | 2009 | Zagazig Journal of Agricultural Research2009，，： | 1 |
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