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| 1 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 2 | Osteopontin as a means to cope with environmental insults:regulation of inflammation, tissue remodeling, and cell survival 显示文摘 | Denhardt DT Noda M O'Regan AW | 2001 | J Clin Invest2001，107，9： | 3 |
| 3 | Glucagon-like peptide-1 receptor imaging with [Lys 40 (Ahx-HYNIC- 99m Tc/EDDA)NH 2 ]-exendin-4 for the detection of insulinoma显示文摘 | Anna Sowa-Staszczak Dorota Pach Renata Miko?ajczak Helmut M?cke Agata Jabrocka-Hybel Agnieszka Stefańska Monika Tomaszuk Barbara Janota Aleksandra Gilis-Januszewska Maciej Ma?ecki Grzegorz Kamiński Aldona Kowalska Jan Kulig Andrzej Matyja Czes?aw Osuch Al | 2013 | European Journal of Nuclear Medicine and Molecular Imaging2013，，4： | 2 |
| 4 | Synergy between angiostatin and endostatin: inhibition of ovarian cancer growth显示文摘 | Yokoyama Y Dhanabal M Griffioen AW | 2000 | Cancer Res2000，60，8： | 2 |
| 5 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 6 | NOS- 2 mediates the protective anti - inflammatory and antifibrotic effects of the Th1 - inducing adjuvant,IL- 12,in a Th2 model of granulomatous disease显示文摘 | Cheever AW Jankovic D | 2000 | Am J Pathol2000，157，3： | 1 |
| 7 | Direct adenoviral transfer of bone morphogenetic protein-2 c- DNA enhances fracture healing in osteoporotic sheep显示文摘 | Egermann M Baltzer AW Adamaszek S | 2006 | Hum Gene Ther2006，17，5： | 1 |
| 8 | Mechanisms of stenosis afler arterial injury显示文摘 | Clowes AW Reidy M Clowes MM | 1983 | Lab Invest1983，49，： | 1 |
| 9 | Diagnostic accuracy of D-dimer test for exclusion of venous thromboembolism:a systematic review显示文摘 | Di Nisio M Squizzato A Rutjes AW | 2007 | J Thromb Haemost2007，5，2： | 1 |
| 10 | Use of music to decrease aggressive behavior in people with Dementia显示文摘 | Clark ME Lipe AW Bilbrey M | 1998 | J of Gerontological Nursing1998，24，7： | 1 |
| 11 | Intra-abdominal complications after surgical repair of Small bowel injuries, an international review显示文摘 | Kirkpatrick AW Mongardini M Schillaci F | 2003 | J Trauma2003，55，3： | 1 |
| 12 | A comparison of teriparatide and calcitonin therapy in postmenopausal Asian women with osteoporosis: a 6-month study 显示文摘 | Kung AW Pasion EG Sofiyan M | 2006 | Curr Med Res Opin2006，22，5： | 1 |
| 13 | Microsatellite analysis of microdissected tumor cells and 6p high density microsatellite analysis in head and neck squamous cell carcinomas with down-regulated human leukocyte antigen class Ⅰ expression 显示文摘 | Feenstra M Verdaasdonk M van der Zwan AW | 2000 | Lab Invest2000，80，： | 1 |
| 14 | PhaseI pharma- cokinetie and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand recep- tor显示文摘 | Tolcher AW Mita M Meropol NJ etal | 2007 | J Clin Oncol2007，25，： | 1 |
| 15 | Flav onoid andchlorogenic acid levels inapple fruit: char acterisation of variation显示文摘 | AW AD M A JAGER A D van WESTING L M | 2000 | Scientia Horticulturae2000，83，34： | 1 |
| 16 | Hetero- duplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations 显示文摘 | Langerak AW Szczepafiski T van der Burg M | 1997 | Leuke- mia1997，11，12： | 1 |
| 17 | Diagnostic accuracy of D - dimer test for exclusion of venous thromboembolism: a sys-tematic review 显示文摘 | Di Nisio M Squizzato A Rutjes AW | 2007 | J Thromb Haemost2007，5，2： | 1 |
| 18 | Iatrogenic nerve injury with the Russell-Taylor humeral nail显示文摘 | Blyth M J Macleod CM Asante DK Kinninmonth AW | 2003 | Injury2003，34，： | 1 |
| 19 | Endothelial cell ex- pression of haemoglobin alpha regulates nitric oxide signalling 显示文摘 | Straub AC Lohman AW Billaud M | 2012 | Nature2012，491，7424： | 1 |
| 20 | Advances in epilep- sy surgery 显示文摘 | Nowell M Miserocchi A McEvoy AW | 2014 | J Neurol Neurosurg Psychiatry2014，85，11： | 1 |
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