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16篇 您的检索式：作者名="Avner JR"

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		题名	作者	年代	出处	被引量
	1	Src inhibition ameliorates polycystie kidney disease显示文摘	Sweeney W E Jr von Vigier R O Frost P Avner E D	2008	J Am Soe Nephrol2008，19，：	1
	2	Practice patterns of pediatric versus general emergency physicians for pain management of fractures in pediatric patients显示文摘	Cimpello LB Khine H Avner JR	2004	Pediatr Emerg Care2004，20，：	1
	3	New insights into the molecular pathophysiology of polycystic kidney disease显示文摘	Murcia NS Sweeney WE Jr Avner ED	1999	Kidney Int1999，55，4：	1
	4	Pattern of pain management during lumbar puncture in children显示文摘	Fein D Avner JR Khine H	2010	Pediatr Emerg Care2010，26，5：	1
	5	Failure of infant observation scales in detecting serious illness in febrile, 4-to 8-week-old infants 显示文摘	Baker MD Avner JR Bell LM	1990	Pediatrics1990，85，6：	1
	6	Unique interstitial miRNA signature drives fibrosis in a murine model of autosomal dominant polycystic kidney disease显示文摘AIM To delineate changes in miRNA expression localized to the peri-cystic local microenvironment(PLM) in an orthologous mouse model of autosomal dominant polycystic kidney disease(ADPKD)(mcwPkd1^(nl/nl)).METHODS We profiled miRNA expression in the whole kidney and laser captured microdissection(LCM) samples from PLM in mcwPkd1^(nl/nl)kidneys with Qiagen miScript 384 HC miRNA PCR arrays. The three times points used are:(1) post-natal(PN) day 21, before the development of trichrome-positive areas;(2) PN28, the earliest sign of trichrome staining; and(3) PN42 following the development of progressive fibrosis. PN21 served as appropriate controls and as the reference time point for comparison of miRNA expression profiles.RESULTS LCM samples revealed three temporally upregulated miRNAs [2 to 2.75-fold at PN28 and 2.5 to 4-fold(P ≤ 0.05) at PN42] and four temporally downregulated miRNAs [2 to 2.75 fold at PN28 and 2.75 to 5-fold(P ≤ 0.05) at PN42]. Expression of twenty-six miRNAs showed no change until PN42 [six decreased(2.25 to 3.5-fold)(P ≤ 0.05) and 20 increased(2 to 4-fold)(P ≤ 0.05)]. Many critical miRNA changes seen in the LCM samples from PLM were not seen in the contralateral whole kidney.CONCLUSION Precise sampling with LCM identifies miRNA changes that occur with the initiation and progression of renal interstitial fibrosis(RIF). Identification of the target proteins regulated by these miRNAs will provide new insight into the process of fibrosis and identify unique therapeutic targets to prevent or slow the development and progression of RIF in ADPKD.	Ameya Patil William E Sweeney Jr Cynthia G Pan Ellis D Avner	2018	World Journal of Nephrology2018，7，5：	1
	7	Outpatient management without antibiotics of fever in selected infants显示文摘	Baker MD Bell LM Avner JR	1993	N Engl J M ed1993，329，20：	1
	8	New insights into the molecular pathophysiology of polycystic kidney disease显示文摘	Sweeney WE Jr Avner ED	1999	Kidney Int1999，55，：	1
	9	Failure of infant observation scales in detecting serious illness in febrile, 4-to 8-week-old infants显示文摘	Baker MD Avner JR Bell LM	1990	Pediatrics1990，85，：	1
	10	Outpatient management without antibiotics of fever in selected infants显示文摘	Baker MD Bell LM Avner JR	1993	N Engl J Med1993，329，：	1
	11	Src inhibition ameliorates polycystic kidney disease 显示文摘	Sweeney W E Jr yon Vigier R O Frost P Avner E D	2008	J Am Soc Nephrol2008，19，7：	1
	12	The heart of the mat-ter:an atypical presentation of Takayasu arteritis in the Pediatric Emergency Department显示文摘	Fein DM Janow G Avner JR	2011	Pediatr Emerg Care2011，27，9：	1
	13	Nebulizer and spacerdevice maintenance in children with asthma显示文摘	Tay ET Needleman JP Avner JR	2009	J Asthma2009，46，2：	1
	14	The heart of the matter:an atypical pres- entation of Takayasu arteritis in the Pediatric Emergency Department显示文摘	Fein DM Ginger J Avner JR	2011	Pediatr Emerg Care2011，27，9：	1
	15	Diagnosis and management ofchildhood polycystic kidney disease显示文摘	Sweeney WE Jr Avner ED	2011	Pediatr Nephrol2011，26，5：	1
	16	New insights into the molecular pathophysiology of polycystic kidney disease显示文摘	Murcia NS Sweeney WE Jr Avner ED	1999	Kidney Int1999，55，4：	1

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