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14篇 您的检索式：作者名="Atkinson RE"

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		题名	作者	年代	出处	被引量
	1	Quorum sensing in Yersinia enterocolitica controls swimming and swarming motility显示文摘	Atkinson S Chang CY Sockett RE	2006	J Bacteriol2006，188，4：	1
	2	Silicon synovitis of the wrist显示文摘	Smith RJ Atkinson RE Juptier JB	1985	J Hand Surg1985，10，：	1
	3	Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems显示文摘	Deuchars SA Atkinson L Brooke RE	2001	J Neurosci2001，21，18：	1
	4	The early critical phase of severe head injury:importance of apnea and dysfunctional respiration显示文摘	Andeson RE Murray MJ	1998	J Trauma1998，45，：	1
	5	The early critical phase of severe head injury:importance of apnea and dysfunction al respiration显示文摘	Atkinson JL Anderson RE Murray M J	1998	JT rauma1998，，05：	1
	6	The Prader-Willi syndrome: a study of 40 patients and a review of the literature 显示文摘	Bray GA Dahms WT Swerdloff RS Fiser RH Atkinson RL Carrel RE	1983	Medicine (Baltimore)1983，62，2：	1
	7	Supracondylar process syndrome: ease report and literature review 显示文摘	Opanova MI Atkinson RE	2014	J Hand Surg Am2014，39，6：	1
	8	Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems显示文摘	Deuchars SA Atkinson L Brooke RE	2001	J Neurosci2001，21，18：	1
	9	The early critical phase of severe head injury : importance of apnea and dysfunctional respiration 显示文摘	Atkinson JL Andemon RE Murray MJ	1998	J Trauma1998，45，5：	1
	10	Surgical evaluation and management of lumbar synovial cysts: the Mayo Clinic expe- rience显示文摘	Lyons MK Atkinson JL Wharen RE	2000	J Neurosurg2000，93，1：	1
	11	显示文摘	Shaoeb MD Watson BN Atkinson RE bleeding complication with enoxaparin for deep venous thrombosis prophylaxis	1999	J Arthroplasty1999，14，4：	1
	12	The early critical phase of severe head injury:importance of apnea and dysfunctional respiration显示文摘	Atkinson JL Anderson RE Murray MJ	1998	J Trauma1998，45，5：	1
	13	Structural and Functional Analysis of E6 Oncoprotein: Insights in the Molecular Pathways of Human Papillomavirus-Mediated Pathogenesis显示文摘	Yves Nominé Murielle Masson Sebastian Charbonnier Katia Zanier Tutik Ristriani Fran?ois Deryckère Annie-Paule Sibler Dominique Desplancq Robert Andrew Atkinson Etienne Weiss Georges Orfanoudakis Bruno Kieffer Gilles Travé	2006	Molecular Cell2006，，5：	1
	14	Genomic profile concordance between pancreatic cyst fluid and neoplastic tissue显示文摘BACKGROUND DNA mutational analysis of pancreatic cystic fluid (CF) is a useful adjunct to the evaluation of pancreatic cysts. KRAS/GNAS or RAF/PTPRD/CTNNB1/RNF43 mutations are highly specific to precancerous or advanced neoplasia. Several studies recently demonstrated the ability of next-generation sequencing (NGS)analysis to detect DNA mutations in pancreatic CF, but few studies have performed a systematic comparative analysis between pancreatic CF and neoplastic surgical tissue (NT). The value of CF-NGS analysis indicators for determining surgical resection necessitates evaluation. AIM To confirm whether CF genomic profiles are a reliable malignancy predictor by comparing NGS mutational analyses of CF and NT. METHODS Patients requiring surgery for high-risk pancreatic cysts were included in a multicenter prospective pilot study. DNA from CF (collected by endoscopic ultrasound-guided fine needle aspiration (known as EUS-FNA)) and NT (collected by surgery) were analyzed by NGS. The primary objective was to compare the mutation profiles of paired DNA samples. The secondary objective was to correlate the presence of specific mutations (KRAS/GNAS, RAF/ PTPRD/CTNNB1/RNF43/POLD1/TP53) with a final cancer diagnosis. Sensitivity and specificity were also evaluated. RESULTS Between December 2016 and October 2017, 20 patients were included in this pilot study. Surgery was delayed for 3 patients. Concordant CF-NT genotypes were found in 15/17 paired DNA, with a higher proportion of mutated alleles in CF than in NT. NGS was possible for all pancreatic CF collected by EUS-FNA. In 2 cases, the presence of a KRAS/GNAS mutation was discordant between CF and NT. No mutations were found in 3 patients with NT or pancreatic cysts with high-grade dysplasia. The sensitivity and specificity of KRAS/GNAS mutations in CF to predict an appropriate indication for surgical resection were 0.78 and 0.62, respectively. The sensitivity and specificity of RAF/PTPRD/CTNNB1 /RNF43/POLD1/TP53 mutations in CF were 0.55 and 1.0, respectively. CONCLUSION Mutational analyses of CF and NT were highly concordant, confirming the value of NGS analysis of CF in the preoperative malignancy assessment. However, these results need to be confirmed on a larger scale.	Arthur Laquière Arnaud Lagarde Bertrand Napoléon Raphael Bourdariat Alexandre Atkinson Gianfranco Donatelli Bernard Pol Laurence Lecomte Laurence Curel Romina Urena-Campos Thierry Helbert Vincent Valantin Francois Mithieux Jean Pascal Buono Philippe Grandval Sylviane Olschwang	2019	World Journal of Gastroenterology2019，25，36：	0

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