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| 1 | Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome显示文摘Diffuse intestinal ganglioneuromatosis is a hamartomatous polyposis characterized by a disseminated, intramural or transmural proliferation of neural elements involving the enteric plexuses. It has been associated with MEN Ⅱ, neurofibromatosis type 1 and hamartomatous polyposis associated with phosphatase and tensin homolog mutation. We report the case of a female patient with a history of a breast and endometrial tumor who presented in a colonoscopy performed for rectal bleeding diffuse ganglioneuromatosis, which oriented the search for other characteristic findings of Cowden syndrome given the personal history of the patient. The presence of an esophagogastric polyposis was also noted. Cowden syndrome is characterized by skin lesions, but it is rarely diagnosed by these lesions, because they are usually overlooked. Intestinal polyposis is not a major diagnostic criterion but it is very useful for early diagnosis. The combination of colonic polyposis and glucogenic acanthosis should orient the diagnosis to Cowden syndrome. | Maria Teresa Herranz Bachiller Jesus Barrio Andrés Fernando Pons Noelia Alcaide Suárez Rafael Ruiz-Zorrilla Lorena Sancho del Val Sara Lorenzo Pelayo Carlos De La Serna Higuera Ramon Atienza Sánchez Manuel Perez Miranda | 2013 | World Journal of Gastrointestinal Oncology2013，5，2： | 5 |
| 2 | Lower serum expression of miR-181c-5p is associated with increased plasma levels of amyloid-beta 1-40 and cerebral vulnerability in normal aging显示文摘Background:Previous studies have shown that expression levels of miR-181c are downregulated by amyloid-β(Aβ)deposition and chronic cerebral hypoperfusion,both factors largely associated with the development of AD.Moreover,reduced 2-[18F]fluoro-2-deoxy-D-glucose(FDG)-PET brain metabolism and volume loss of regions of the medial temporal lobe have been generally recognized as hallmarks of AD.Based on this evidence,we have here investigated potential associations between serum levels of miR-181c-5p and these AD signatures in asymptomatic elderly subjects.Methods:Ninety-five normal elderly subjects underwent clinical,cognitive,structural MRI,and FDG-PET explorations.Serum expression levels of miR-181c-5p and plasma Aβ concentrations were further analyzed in this cohort.Regression analyses were performed to assess associations between serum miR-181c-5p levels and cognitive functioning,plasma Aβ,structural and metabolic brain changes.Results:Decreased serum expression of miR-181c-5p was associated with increased plasma levels of Aβ1–40,deficits in cortical glucose metabolism,and volume reduction of the entorhinal cortex.No significant associations were found between lower miR-181c-5p levels and cognitive deficits or cortical thinning.Conclusions:These findings suggest that deregulation of serum miR-181c-5p may indicate cerebral vulnerability in late life. | Marta Manzano-Crespo Mercedes Atienza Jose L.Cantero | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 3 | A probabilistic model of cardiac electrical activity based on a cellular automata system显示文摘 | ATIENZA F A CARRIóN J R ALBEROLA A G | 2005 | Rev Esp Cardiol2005，58，1： | 1 |
| 4 | Acute and long-term outcome of transvenous cryoablation of midseptal and parahissian accessory pathways in patients at high risk of atrioventricular block during radiofrequency ablation显示文摘 | Atienza F Arenal A Torrecilla EG | 2004 | Am J Cardiol2004，93，10： | 1 |
| 5 | Decay time of the auditory sensory memory trace during wakefulness and REM sleep 显示文摘 | Atienza M Cantero JL Gomez C | 2000 | Psyehophysiology2000，37，： | 1 |
| 6 | Influence of clarification, yeast type, and fermentation temperature on the organic acid and higher alcohols of Malaise and Muscatel wines显示文摘 | ARAGON P ATIENZA J CLIMENT M D | 1998 | American Journal of Enology and Viticulture1998，，49： | 1 |
| 7 | Peripheral T-cell lymphoma with follicular T-cell markers显示文摘 | Rodriguez-Pinilla SM Atienza L Murillo C | 2008 | Am J Surg Pathol2008，32，12： | 1 |
| 8 | Dynamic monitoring of cell adhesion and spreading on microelectronic sensor arrays显示文摘 | ATIENZA J M ZHU J WANG X B | 2005 | Journal of Biomolecular Screening2005，10，8： | 1 |
| 9 | Compressed sensing for real-time energy-efficient ECG compression on wireless body sensor nodes显示文摘 | Mamaghanian H Khaled N Atienza D | | 0，，09： | 1 |
| 10 | Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury显示文摘 | Moodley Y Atienza D Manuelpil ai U | | 0，，01： | 1 |
| 11 | Reduction of basal forebrain cholinergic system parallels cognitive impairment in patients at high risk of developing Alzheimer's disease 显示文摘 | Grothe M Zaborszky L Atienza M | 2010 | Cereb Cortex2010，20，7： | 1 |
| 12 | Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells显示文摘 | Cowan C A Atienza J Melton D A | 2005 | Science2005，309，5739： | 1 |
| 13 | Muhieenter ran - domized trial of a comprehensive hospital discharge and outpatient heart failure management program 显示文摘 | Atienza'F Anguita M Martinez - Alzamora N | 2004 | Eur J Heart Fail2004，6，5： | 1 |
| 14 | Nuclear reprogramming of somatic cells after fusion with human embryonic stem cell显示文摘 | Cowan CA Atienza J Melton DA | 2005 | Science2005，309，： | 1 |
| 15 | Design and exploration of low-power analog to information conversion based on compressed sensing显示文摘 | MAMAGHANIAN H KHALED N ATIENZA D | 2012 | IEEE Journal on Emerging and Selected Topics in Circuits and Systems2012，2，3： | 1 |
| 16 | The time course of neural changes underlying auditory perceptual learning显示文摘 | Atienza M Cantero JL Dominguez--Marin E | 2002 | Learn Mem2002，9，： | 1 |
| 17 | Measuring directional coupling between EEG sources显示文摘 | Gomez-Herrero G Atienza M Egiazarian K | 2008 | Neuroimage2008，43，3： | 1 |
| 18 | Compressed Sensingfor iieal-Tinie Energy-Efficient ECG Compression on WirelessBody Sensor No(ies 显示文摘 | Mamaghanian H Khaled N Atienza D et ai | | IEEE Transactions on Biomedical Engi-neering0，58，9： | 1 |
| 19 | Precise timing accounts for posttraining sleep--dependent enhancements of the auditory mismatch negativity显示文摘 | Atienza M Cantero JL Quian Quiroga R | 2005 | Neuroimage2005，26，： | 1 |
| 20 | Intervention - re-lated cognitive versus social mediators of exercise adherence inthe elderly显示文摘 | Brassington GS Atienza AA Perczek RE ei al | 2002 | Am J Prevent Med2002，23，1： | 1 |
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