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| 1 | Child-Pugh-Turcott versus Meld score for predicting survival in a retrospective cohort of black African cirrhotic patients显示文摘AIM: To compare the performance of the Child-Pugh-Turcott (CPT) score to that of the model for end-stage liver disease (MELD) score in predicting survival of a retrospective cohort of 172 Black African patients with cirrhosis on a short and mid-term basis.METHODS: Univariate and multivariate (Cox model) analyses were used to identify factors related to mortality. Relationship between the two scores was appreciated by calculating the correlation coefficient. The Kaplan Meier method and the log rank test were used to elaborate and compare survival respectively. The Areas Under the Curves were used to compare the performance between scores at 3, 6 and 12 mo.RESULTS: The study population comprised 172 patients, of which 68.9% were male. The mean age of the patient was 47.5 ± 13 years. Hepatitis B virus infection was the cause of cirrhosis in 70% of the cases. The overall mortality was 31.4% over 11 years of follow up. Independent factors significantly associated with mortality were: CPT score (HR = 3.3, 95% CI [1.7-6.2]) (P < 0.001) (stage C vs stage A-B); Serum creatine (HR = 2.5, 95% CI [1.4-4.3]) (P = 0.001) (Serum creatine > 1.5 mg/dL versus serum creatine < 1.5 mg/dL); MELD score (HR = 2.9, 95% CI [1.63-5.21]) (P < 0.001) (MELD > 21 vs MELD < 21). The area under the curves (AUC) that predict survival was 0.72 and 0.75 at 3 mo (P = 0.68), 0.64 and 0.62 at 6 mo (P = 0.67), 0.69 and 0.64 at 12 mo (P = 0.38) respectively for the CPT score and the MELD score.CONCLUSION: The CPT score displays the sameprognostic significance as does the MELD score in black African patients with cirrhosis. Moreover, its handling appears less cumbersome in clinical practice as compared to the latter. | KA Attia KC Ackoundou-N'guessan AT N’dri-yoman AK Mahassadi E Messou YF Bathaix YH Kissi | 2008 | World Journal of Gastroenterology2008，14，2： | 5 |
| 2 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 3 | Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects显示文摘 | Owen, KR Groves, CJ Hanson, RL Knowler, WC Shuldiner, AR Elbein, SC Mitchell, BD Froguel,P Ng, MCY Chan, JC Jia, WP Deloukas, P Hitman, GA Walker, M Frayling, TM Hattersley, AT Zeggini, E McCarthy, MI | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 4 | Pyrolysis characteristics and kinetics of biomass residuals mixtures with lignite显示文摘 | Vamvuka D Kakaras E Kastanaki E et at | 2003 | Fuel2003，82，1517： | 1 |
| 5 | The shape and internal s tructure of the moon from the clementine mission 显示文摘 | D E Smith F G Lemoine at el | 1994 | Science1994，226，： | 1 |
| 6 | Revised classification scheme of phytoplasmas based on RFL panalyses of 16S rRNA and ribosomal protein gene sequences 显示文摘 | Lee I M Gundersen R D E Davis R E et at | 1998 | Int J Syst Acteriology1998，48，： | 1 |
| 7 | Effects of spatial variabilily and scale with implication to hydrologic modeling显示文摘 | Wood E F Sivapalan M Bern K J el at | 1988 | Journal of Hydrology1988，102，： | 1 |
| 8 | Uterine fibroid vascularization and clinical relevance to Uterine fibroid embolization 显示文摘 | Pelage JP Cazejust J Pluot E at al | 2005 | Radiographics2005，25，1： | 1 |
| 9 | A review of paired catchment studies for determining changes in water yield resulting from alterations in vegetation显示文摘 | Brown A E Zhang Lu McMahon T A et at | 2005 | Journal of hydrology2005，310，14： | 1 |
| 10 | The effect of perioperative infused dexmidetomidine on postoperative analgesic consumption in rnastoidectomy operations 显示文摘 | Si'dlei AT Ozyuvaci E Alkan Z | 2010 | J Turkish Soc Algol2010，22，3： | 1 |
| 11 | Interleukin (IL) -19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs 显示文摘 | Kunz S W olk K Witte E et at | 2006 | Exp Dennatol2006，5，12： | 1 |
| 12 | Detection of carotid adventitiaI vasa vasorum and plaque vascularization with ultrasound cadence contrast pulse sequencing technique and echo- contrast agent显示文摘 | Vicenzini E Giannoni M F Puccinelli F et at | 2007 | Stroke2007，38，10： | 1 |
| 13 | Cardiac safety of donepe- zil in elderly patients with Alzheimer disease显示文摘 | Isik AT Yildiz GB Bozoglu E | 2012 | Intern Med2012，51，6： | 1 |
| 14 | Evolution of local structure in geopolymer gels: An in situ neutron pair distribution function analysis 显示文摘 | WHITE C E PROVIS J L LLOBET A et at | 2011 | JAm Ceram Soc2011，94，10： | 1 |
| 15 | Effects of salicylic acid and cold on freezing tolerance in winter wheat leaves 显示文摘 | Ta?gín E Atící ? Nalbanto?lu B | 2003 | Plant Growth Regulation2003，41，3： | 1 |
| 16 | The risk of seizure recurrence after a first unprovoked afebrile seizure in childhood: an extended follow-up 显示文摘 | Shinnar S Berg AT Mosbe SL e~ al | 1996 | Pediatrics1996，98，21： | 1 |
| 17 | Biocompatibility of composites-literature review显示文摘 | LEDERMAN M SHARON E LIPOVEZKY-ADLER M et at | 2015 | Refuat Hapeh Vehashinayim2015，32，1： | 1 |
| 18 | Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors 显示文摘 | Springuel L Hornakova T Losdyck E et at | 2014 | Blood2014，124，26： | 1 |
| 19 | Late angiographic stent throm-bosis (LAST) events with drug - eluting stents 显示文摘 | Ong AT McFadden EP Regar E | 2005 | J Am Coll Cardiol2005，45，： | 1 |
| 20 | Diagnostic accuracy of varying discrminatory zones for the prediction of ectopic pregnancy in women with a pregnancy of unknown location 显示文摘 | Condous G Kirk E Lu C at al | 2005 | Ultrasound Obstet Gynecol2005，26，7： | 1 |
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