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| 1 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 2 | Effects of aminoguanidine on nitric oxide production induced by inflammatory cytokines and endotoxin in cultured rat hepatocytes显示文摘AIM To study the effects of aminoguanidine(AG) and two L-arginine analogues Nω-nitro-L-arginine methyl ester (L-NAME) and Nω-nitro-L-arginine (L-NNA) on nitric oxide (NO) productioninduced by cytokines (TNF-α, IL-11β, and IFN-γ)and bacterial lipopolysaccharide (LPS) mixture(CM) in the cultured rat hepatocytes, andexamine their mechanisms action.METHODS Rat hepatocytes were incubatedwith AG, L-NAME, L-NNA, Actinomycin D (ActD)and dexamethasene in a medium containing CM(LPS plus TNF-α, IL-1β, and IFN-γ) for 24 h. NOproduction in the cultured supernatant wasmeasured with the Griese reaction. IntracellularcGMP level was detected with radioimmunoasey.RESULTS NO production was markedlyblocked by AG and L-NAME in a dose-dependentmanner under inflammatory stimuli conditiontriggered by CM in vitro. The rate of themaximum inhibitory effects of L-NAME (38.9%)was less potent than that obtained with AG(53.7%, P<0.05). There was no significantdifference between the inhibitory effects of AGand two L-arginine analogues on intracellularcGMP accumulation in rat cultured hepatocytes.Non-specific NOS expression inhibitordexamethasone ( DEX ) and iNOS mRNAtranscriptional inhibitor ActD also significantlyinhibited CM-induced NO production. AG(0.1mmol.L-1) and ActD (0.2ng@Lt) wereequipotent in decreasing NO production inducedby inflammatory stimuli in vitro, and botheffects were more potent than that induced bynon-selectivity NOS activity inhibitor L-NAME(0. 1 mmol@ L- 1) under similar stimuli conditions(P | Guo Liang Zhang Ye Hong Wang Hui Ling Teng Zhi Bin Lin Department of Pharmacology,School of Basic Medical Sciences,Beijing University,Beijiog 100083,ChinaDr.Guo Liang Zhang graduated from Xinxiang Medical College in 1982,got Ph.D.at Nagoya City University Medical School,Japan in 1994,finished postdoctoral research at Beijing Medical Univcrsity in 1996,now an associate professor of pharmacology,specialized in hepatic pharmacology,having 15 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 20 |
| 3 | The Bedload Movement in the Changjiang Estuary显示文摘- Sandwaves in the Changjiang estuary were measured with a shallow sediment profiler and an echosounder from 1978 to 1988. The data, together with grain size and bedform of sediment indicates that the bedload movement by rolling and saltation is of great significance to sediment transport and is the principal factor responsible for sandwave and sandbody development in the estuary. The sandwaves were found well-developed, which is related to the tidal range and the velocity of ebb current. However, the further growth is restricted by strong flood current prevailing in the estuary. Because of the significant bedload, the sandbodies shift obviously and frequently, and sometimes the exchange of position occurs between the sandbodies and tidal channels. As a result, ships are regularly forced to change their navigation course. | Li Jiufa, Shi Weirong, Shen Huanting Xu Haigen and Doeke Eisma Associate Professor, Institute of Estuarine & Coastal Research (1ECR), East China Normal University, Shanghai200062 Professor, IECR, East China Normal University, Shanghai 200062 Professor, Netherlands Institute for Sea Research, P. O. Box 59 1790 AB, Den Burg, Texel, The Netherlands | 1993 | China Ocean Engineering1993，8，4： | 15 |
| 4 | Housing Wealth, Financial Wealth and Consumption in China显示文摘纸在城市的中国在财产财富和家庭消费的趋势运动调查在变化之间的关系。用向量错误修正 cointegration 模型,我们证明在城市的中国在家庭消费,可处理的收入,金融财富和住房财富之间有一种唯一的长期间 cointegrating 关系。当 cointegrated 系统被外部震动扰乱时,我们发现住房财富是恢复长期间平衡关系的唯一的因素。另外,我们的永久临时的变化分解分析都显示那在消费的运动的变化是永久的,支持消费行为的古典随机的散步假设。然而,在住房财富的短期的运动的变化的一个大比例被发现临时。 | Jie Chen Feng Guo Aiyong Zhu Associate Professor,School of Management,Fudan University,Shanghai,China. Senior Research Economist and Economics Lecturer,Haile/US Bank College of Business,Northern Kentucky University,Highland Heights,USA. Master Student,School of Economics,Fudan University,Shanghai,China. | 2009 | China & World Economy2009，17，3： | 10 |
| 5 | Recent Progress in Image Coding显示文摘RecentProgresinImageCodingFanChangxinLuZhaoyang(XidianUniversity,Xi’an710071)AbstractTheworksonimagecodinginrecenttwoye... | Fan ChangxinFan Changxin is with Xidian University, Professor,FCIC,FCIE,FIEE,FIEEE Lu ZhaoyangLu Zhaoyang is with Xidian University, Ph.D.,Associate Researcher (Xidian University, Xi’an 710071) | 1998 | 通信学报1998，19，5： | 5 |
| 6 | “Color Revolutions” and Beyond显示文摘“Color revolutions” (or “orange revolutions”) broke out in some of the Commonwealth of Independent States in the past couple of years, reminiscent of the drama of disintegration of the former Soviet bloc at the turn of the 1990s. Why those upheavals came hot on the heels of the Soviet collapses merely a dozen or so years ago? Are we expecting more domino effects down the road? What geographical repercussions will they spark? A panel discussion was held on the topic and their views published in the journal. | Dr. Ji Zhiye is Research Professor and Assistant President of China Institutes of Contemporary International Relations (CICIR), and Director of the Institute of Russian Studies concurrently. He is editor and coauthor of many books including Russian Think-Tanks on Foreign Affairs and The Shanghai Cooperation Organization——New Security and New Mechanism. Dr. Xu Tao is Research Professor and Deputy Director of the Institute of Russan Studies, CICIR. Jiang Li is Associate Research Professor of the Institute of Russian Studies, CICIR. Da Wei is Assistant Director of the Institute of American Studies, CICIR. Dr. Chen Xiangyang is Deputy Director of the Center for Strategic Studies, CICIR. Ding Xiaoxing is Assistant Research Professor of the Institute of Russian Studies, CICIR. | 2005 | Contemporary International Relations2005，15，6： | 3 |
| 7 | Local Practices on Transfer of Development Rights in China: Background, Mode, Challenge and Breakthrough | WANG Hui, PhD, Part-time Researcher, Peking University-Lincoln Institute Center Associate Professor,Zhejiang University, Hangzhou, P. R. China. WANG Lanlan, PhD, Part-time Researcher, Peking University-Lincoln Institute Center Assistant Professor, Central University of Finance and Economics,Beijing, P. R. China. TAO Ran, PhD, Part-time Researcher, Peking University-Lincoln Institute Center Professor, RenminUniversity of China, Beijing, P. R. China. SHI Ke | 2012 | China City Planning Review2012，21，1： | 2 |
| 8 | VELOCITY PROFILE OF SEDIMENT-LADEN OPEN CHANNEL FLOW显示文摘A detailed literature survey of the existing models for vertical velocity profiles of open channel flow for both clear water and sediment-laden water is performed. It is found that flow resistance and suspended sediment particles affect velocity profiles significantly. The Karman constant K of the logarithmic law is equal to 0.41 near the channel bed but far from the bed the value will change due to flow resistance and sediment suspension. The exponent of the power law velocity profile is also affected by those two factors. A general logarithmic law and a general power law for the description of velocity profiles arc proposed herein and verified by the experiment data presented by several investigators. Satisfactory results were obtained. | LEE Hong Yuan and YU Wei Sheng Associate Professor, Dept. of Civil Engineering, National Taiwan University, Taipei, Taiwan, China Graduate Research Assistant, Dept. of Civil Engineering, National Taiwan University, Taipei, Taiwan, China | 1991 | International Journal of Sediment Research1991，6，1： | 2 |
| 9 | Evalution of Application of p-y Curve Method in Offshore Engineering Foundation显示文摘- Based on the Mohr-Coulomb failure principle and Rankine’s theory, the laterally loaded pile ultimate resistance formulas of sand and soft clay proposed by Reese and Matlock respectively are discussed in this paper. The authors put forward the modified ultimate resistance formulas on the basis of which the ultimate resistance formula is developed for horizontally loaded pile in multi-layer soil in consideration of the effect of the overburden soil pressure on the calculation of soil layer. It is significant to the correct application of the ultimate resistance formulas in API and ZCS Rules into offshore engineering. | Jin Weiliang, Zhu Yuming and Li Linpu Associate Professor, Dr. -Eng., Zhejiang University, Hangzhou Engineer, Metallurgical Building Design and Research Institute, Beijing Associate Professor, Dalian University of Technology, Dalian | 1993 | China Ocean Engineering1993，8，4： | 2 |
| 10 | A NEW TECHNIQUE—ELECTROMAGNETIC CENTRIFUGAL CASTING PROCESS显示文摘A new technique of centrifugal casting under electromagnetic field was firstly proposedand investigated.Taking a heat resisting alloy steel 25Cr20Ni and an Al-Cu alloyas examples,products,though their length,diameter and wall thickness are varied,re-vealed so superior macrostructures that the mechanical properties are much improved incomparison with conventional centrifugal casting. | GE Yunlong YANG Yuansheng JIAO Yuning HU Zhuangqi Institute of Metal Research,Academia Sinica,Shenyang,ChinaGAO Yunyan JIA Guanglin Northeast University of Technology,Shenyang,China associate professor,Institute of Low Energy Nuclear Physics,Beijing Normal University,Beijing,100875,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，11： | 2 |
| 11 | The Growth of China’s Private Sector: A Case Study of Zhejiang Province显示文摘Private capital is one of the main driving forces in China’s initiatives towards stimulating the market economy. The development of private economy in China has always been based on integrating industrial and corporate structures with product composition and market structures. This paper explores the development of the private economy and how it integrates different industries with specific markets by analyzing the leading private sector in Zhejiang province. It also examines the trends of industrial cluster, the formation of the agglomerative economy and their effects on private economy development. Finally, the paper explains why Zhejiang people have profited much from the Wenzhou model, and discusses some existing problems and future possibilities for development of the Wenzhou model. | Zhikai Wang*Associate Professor, Department of Economics ,College of Economics and Centre for Research in Private Enterprise, Zhejiang University, China. | 2006 | China & World Economy2006，14，3： | 2 |
| 12 | FIELD INVESTIGATION INTO DEBRIS FLOW MECHANISM显示文摘Debris flow carries huge amount of sediment, from clay finer than 10-3 mm to huge stonesof several meters in diameter. Clay, sand, gravels and boulders move in different mechanisms.Field investigations performed by the authors reveal that there are two kinds of debris flowswith different mechanismst viscous debris now and two-phase debris flow. viscous debrisflow consists of more fine material and exhibits intermittent flow, paving way process, dragreduction and high superelevation. Drag reduction is caused by the paving way process andaeration of the flowing mixture. Two-phase debris flow consists mainly of coarse materialand exhibits steep stone front, stone street, inverse grading and higher resistance.Investigation on the slope of debris flow gullies shows that the coarser the debris material thehigher the slope of the gullies. | ZhaoYin WANG1, Onyx W.H. WAI2 and Peng CUI3(1 Professor, International Research and Training Center on Erosion and Sedimentation, P.O.Box 366, Beijing100044. P.R. China.)(2 Associate Protbssor, Dept. of Civil and Structural Engineering, Hong Kong Poly-te | 1999 | International Journal of Sediment Research1999，14，4： | 2 |
| 13 | ANALYSIS OF DYNAMIC STABILITY OF SUBMERGED STRUCTURE显示文摘The submerged structure is basically a large three-dimensional structure of few statically redundant members. The structure is subjected to vertical dead and live loads in addition to the wave forces. An analysis of dynamic stability of the submerged structure without damping has been made by J. Thomas and Abbas (1980). In this paper the analyses of dynamic stability of the sumberged structure with damping are conducted. The case structure with damping is more complicated ’than the case without it. According to the principle of perturbation, a new model for dynamic stability calculation in consideration of damping effect is developed. In this paper, the formulas are deduced, the computational program is compiled, the practical examples are analysed, and this problem is solved very satisfactorily. The computational results show that the shape and value of the regions of dynamic instability can be changed significantly by damping. So only by considering damping can the property of dynamic stability of the submerged structure be reflected correctly. | Qu Naisi , Yang Chunqiu and Tao Zhengguo Associate Professor, Dalian University of Technology, Dalian, Engineer, Wuxi 706 Research Institute, Wuxi | 1990 | China Ocean Engineering1990，5，2： | 2 |
| 14 | Housing Reform: The Impact on China's Macroeconomy显示文摘MajorinstitutionalbreakthroughsinChina'surbanhousingsectorhavebeenproposedbythenewcentraladministrationsinceearly1998.Somemeasuresarenowineffect.ThispaperwishestoassesstheimpactoftheurbanhousingreformonChina'smacroeconomicmovement.Partonebriefsthegen... | He Liping Ph.D(Associate Professor,China Institute of Banking, and Senior Fellow,the National Economic Research Institute,China Reform Foundation) | 2000 | World Economy & China2000，8，Z1： | 2 |
| 15 | BED FORMS AND RESISTANCE PROPERTIES OF LIGHT-WEIGHT BED MATERIAL显示文摘Based on experimental results from a large tilting flume, the characteristics and de- veloping processes of bed forms of plastic particles during scouring and deposition are systematically studied. The relationships of the occurence, development and disappearence of sand waves with the flow conditions are presented. Various statistical characteristics of sand waves with different sizes and the corresponding resistance properties of different bed forms of plastic particles are obtained. These results have filled in the gaps in bed forms and resistance properties of light sediment particles. It also serves as useful reference in the design of river model tests. | WANG Guixian ,WANG Xingkui,GUO Jiachao Professor, Sediment Research Laboratory, Dept. of Hydraulic Engineering, Tsinghua University, Beijing 100084, China. Associate Professor, Dept. of Hydraulic Engineering, Tsinghua University. Assistant, Dept. of Hydraulic Engineering, Tsinghua University. | 1993 | International Journal of Sediment Research1993，8，3： | 2 |
| 16 | Experimental Wave Power Plant at the Pearl River Estuary显示文摘The first Chinese experimental wave power plant, i. e., the shoremountcd experimental wave power plant at the Pearl River Estuary was successful in trial power generation on February 15, 1990. The plant is on the south shore of the Dawanshan Island in the Pearl River Estuary, facing the vast waving South China Sea. With a designed wave condition of H1/10= 1.5 m and T= 6.5 s, the planned installed capacity is 8 kW comprising the first unit of 3 kW brushless clawpole generator which delivers 110 V DC current and the second unit of 5 kW brushless single phase synchro AC generator which delivers 220 V AC current. At present, the first unit has been put into trial operation. | Liang Xianguang, Gao Xiangfan, Zheng Wenjie Yu Zhi, Jiang Niandong, Hou Xiangqin and You Yage 1. Associate Professor, Guangzhou Institute of Energy Conversion, the Chinese Academy of Sciences, Guangzhou2. Senior Engineer, Guangzhou Institute of Energy Conversion, the Chinese Academy of Sciences, Guangzhou3. Assistant Researcher, Guangzhou Institute of Energy Conversion, the Chinese Academy of Sciences, Guangzhou4. Engineer, Guangzhou Institute of Energy Conversion, the Chinese Academy of Sciences, Guangzhou | 1991 | China Ocean Engineering1991，6，4： | 1 |
| 17 | Inner Regulations Determine General Trend显示文摘The orientation of bilateral relations in the two countries’ external strategy plays a decisive role in the general trend of bilateral relations. Demand plays the major decisive role in the strategic orientation of external relations. Only when demand is needed, there is a driving force in developing relations. Thus importance will be attached to | Hu Jiping is an Associate Research Professor and Deputy Director at the Division for Northeast Asian Studies, China Institute of Contemporary International Relations. | 2003 | Contemporary International Relations2003，13，11： | 1 |
| 18 | MICROSTRUCTURAL STUDIES OF ULTRAFINE IRON PARTICLES显示文摘The constitution,structure and surface state of the ultrafine iron particles prepared by gasevaporation technique have been investigated by means of X-ray analysis,high-reasolutionelectron microscopy(HREM)and electron spectroscopy for chemical analysis(ESCA).Theresults showed that the fine particles are spherical ones of~20 nm in diameter with α-Fecores and covered by Fe3O4 fine crystalline layers of~4 nm thickness. | WANG Shuhe CAI Yuling AN Gang WEN Lishi ZHUANG Yuzhi Institute of Metal Research,Academia Sinica,Shenyang,China WANG Shuhe,Associate Professor,Institute of Metal Research,Academia Sinica,Shenyang 110015,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，8： | 1 |
| 19 | International Geostrategic Situation and China's Choices显示文摘I ntense volatility marked the international geopolitical situation in the first year of the new century. Especially promoted by the war in Afghanistan, the post-Cold War readjustment in world geopolitical structure has speeded up, and | Lin Limin Associate Research professor Deputy Director at Division for World Politics Studies, China Institute: of Contemporary International Relations. | 2002 | Contemporary International Relations2002，12，4： | 1 |
| 20 | Afghanistan Reconstruction显示文摘The post-war reconstruction in Afghanistan is going on smoothly within the framework of the Bonn Agreement, and the country has come back to normal as far as the appearance goes. However, with foreign involvement, economic recovery has lagged behind the political reconstruction. Worse still, the Afghan government is now facing a series of challenges including worse situation, revival of warlords, drug economy, poverty and political corruption, etc. Besides, the negative impacts of over-dependence on the United States are now gradually revealing themselves, and uncertainties lie ahead. | Fu Xiaoqiang is an Associate Professor of the Institutes of Asian and African Studies, and Deputy Director of the Center for Crisis Management, CICIR. He has research interests in South Asian and regional security. He has published a large number of academic articles such as “The Emergence of India and South Asian Security,” “Development of Pakistan’s Policy toward China and Its Trend,” “An Analysis of the Historical Roots of Kashimir Issue,” etc. He is also the author of Ethnic and Religious Issues in China’s Neighboring Countries (2002). | 2006 | Contemporary International Relations2006，16，6： | 1 |
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