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| 1 | Association between thrombotic risk factors and extent of fibrosis in patients with non-alcoholic fatty liver diseases显示文摘AIM: To evaluate the prevalence of genetic and acquired prothrombotic risk factors and their association with the extent of fibrosis and fatty infiltration in patients with non-alcoholic fatty liver disease (NAFLD).METHODS: Forty-four patients with chronic hepatitis (28 men and 16 women, with mean age of 45±11 and 49±12 years, respectively) constituted the patient population of this study. The groups were divided as follows: 15 patients with fatty liver (FL); 15 with non-alcoholic steatohepatitis (NASH); 14 with chronic viral hepatitis (CH) diagnosed by histology and liver technetium scan or ultrasound; and 10 healthy individuals. Thrombophilic, coagulation factors and genetic mutations were diagnosed by standard hemostatic and molecular coagulation assays.RESULTS: Activated protein C (APC) resistance and protein S were the most prevalent thrombotic risk factors (6% and 10% in NAFLD vs 21% and 14% in CH; P<0.01 and P<0.05, respectively). One thrombotic risk factor was identified in 41% of patients (23% mild fibrosis, 18% severe fibrosis) and two thrombotic risk factors in 6% of patients with NAFLD and severe fibrosis. While no differences in APC ratio, lupus anticoagulant, fibrinogen, factor V Leiden,prothrombin, and MTHFR mutation were found. Protein S levels were significantly lower in NASH patients than in patients with FL alone (92±19 vs106±2, P<0.01). Protein C levels were markedly higher in patients with NAFLD and mild or severe fibrosis as compared to the patients with CH, respectively (128±40 vs96±14, P<0.001 or 129±36 vs 88±13, P<0.01).CONCLUSION: Up to 46% of patients with NAFLD may have thrombotic risk factors, and the presence of thrombotic risk factors is correlated with the extent of hepatic fibrosis,suggesting a crucial role of the coagulation system in the pathogenesis of hepatic fibrosis. | N Assy I Bekirov Y Mejritsky L Solomon S Szvalb O Hussein | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 2 | A Real Options Approach to Ship Investment Appraisal 显示文摘 | PIRES F C M ASSIS L F FIHO M R | 2012 | African Journal of Business Management2012，6，25： | 1 |
| 3 | Antioxidant activity, ascorbic acid and total phenol of exotic fruits occurring in Brazil显示文摘 | Aparecida de Assis S Vellosa J C R Brunetti I L | 2008 | International journal of food sciences and nutrition2008，60，5： | 1 |
| 4 | Optimisation of COREX process 显示文摘 | ASSIS P S GUO L FANG J | 2008 | Ironmaking and Steelmaking2008，35，4： | 1 |
| 5 | Helicobacter pylori induces mi R-155 in T cells in a c AMP-Foxp3-dependent manner显示文摘 | F assi Fehri L Koch M Belogolova E | 2010 | Plo S One2010，5，3： | 1 |
| 6 | First-line treatment with capecitabine combined with irinotecan in patients with advanced colorectal carcinoma:a phase II study显示文摘 | Assy N Basher W Chetver L | 2012 | J Clin Gastroenterol2012，46，4： | 1 |
| 7 | Corrosion characterization of titanium alloys by electrochemical techniques显示文摘 | Assis S L D Wolynec S Costa I | | 0，，： | 1 |
| 8 | Betulinic acid: isolation from TriphyophyUum peltatum and Ancistrocladus heyneanus, antimalarial activity, and crystal structure of the benzyl ester 显示文摘 | BRINGMANN G SAEB W ASSI L A | 1997 | Planta Med1997，63，： | 1 |
| 9 | Effect of platelet-activating factor antagonists(BN-52021,WEB-2170,and BB-882)on bacterial translocation in acute pancreatitis显示文摘 | de Souza L J Sampietre S N Assis R S | 2001 | J Gastrointest Surg2001，5，4： | 1 |
| 10 | Acquistion of Tomato spotted wilt virus by Adults of Two Thrips Species 显示文摘 | de ASSIS FILHO F M DEOM C M SHERWOOD J L | 2004 | Phytopathology2004，94，4： | 1 |
| 11 | Effect of the composition and sintering process on the electrical properties in Pb(Mg1/3 Nb2/3) O3-PbTiO3 ceramics显示文摘 | Zanin A L Assis S B | 2004 | Journal of the European Ceramic Society2004，24，6： | 1 |
| 12 | Development and analytical validation of a simple multivariate calibration method using digital scanner images for sunset yellowdetermination in soft beverages显示文摘 | Botelho B G Assis L P Sena M M | 2014 | Food Chemistry2014，，159： | 1 |
| 13 | Fluorapatite solubilization by Aspergillus Niger in vinasse medium 显示文摘 | Nahas E Banzatto D A Assis L C | 1990 | Soil Biology and Biochemistry1990，22，8： | 1 |
| 14 | Evaluation of a micro-tomography system with an X-ray microfocus tube 显示文摘 | Lopes R T Rodrigues J L De Assis J T | 1997 | Appl Radiat Isot1997，48，1012： | 1 |
| 15 | Synthesis by sol-gel process,characterization and catalytic activity of vanadia-silica mixed oxides显示文摘 | Figueiredo M A Faria A L D Assis M D D | 2005 | Journal of Non-Crystalline Solids2005，351，4648： | 1 |
| 16 | First evidences of the occurrence of polycyclic synthetic musk fragrances in surface water systems in Italy: Spatial and temporal trends in the Molgora River (Lombardia Region, Northern Italy) 显示文摘 | Villa S Assi L Ippolito A | 2012 | Science of the Total Environment2012，416，： | 1 |
| 17 | Soil carbon stocks after forest conversion to tree plantations in lowland Amazonia, Brazil 显示文摘 | Smith C K de Assis Oliveira F Gholz H L | 2002 | Forest Ecology and Management2002，164，123： | 1 |
| 18 | Analysis of coffee harvesting process by vibration 显示文摘 | Queiroz D M Santos F L Assis F | 2007 | American Society of Agricultural and Biological Engineers2007，76，14： | 1 |
| 19 | Insecticide activity of surfactins and iturins from a biopesticide Bacillus subtilis Cohn (S499 strain)显示文摘 | Assie L K Deleu M Arnaud L | 2002 | Mededelingen2002，67，3： | 1 |
| 20 | Insecticide activity of surfactins and iturins from a biopesticide Bacillus subtilis Cohn (S499 strain)显示文摘 | Assie L K Deleu M Amaud L | 2002 | MededRijksuniv Gent Fak Landbouwkd Toegep Biol Wet2002，67，3： | 1 |
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