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| 1 | Reliability in endoscopic diagnosis of portal hypertensive gastropathy显示文摘AIM: To analyze reliability among endoscopists in diagnosing portal hypertensive gastropathy (PHG) and to determine which criteria from the most utilized classifications are the most suitable. METHODS: From January to July 2009, in an academic quaternary referral center at Santa Casa of S o Paulo Endoscopy Service, Brazil, we performed this singlecenter prospective study. In this period, we included 100 patients, including 50 sequential patients who had portal hypertension of various etiologies; who were previously diagnosed based on clinical, laboratory and imaging exams; and who presented with esophageal varices. In addition, our study included 50 sequentialpatients who had dyspeptic symptoms and were referred for upper digestive endoscopy without portal hypertension. All subjects underwent upper digestive endoscopy, and the images of the exam were digitally recorded. Five endoscopists with more than 15 years of experience answered an electronic questionnaire, which included endoscopic criteria from the 3 most commonly used Portal Hypertensive Gastropathy classifications (McCormack, NIEC and Baveno) and the presence of elevated or flat antral erosive gastritis. All five endosco- pists were blinded to the patients' clinical information, and all images of varices were deliberately excluded for the analysis. RESULTS: The three most common etiologies of portal hypertension were schistosomiasis (36%), alcoholic cirrhosis (20%) and viral cirrhosis (14%). Of the 50 patients with portal hypertension, 84% were Child A, 12% were Child B, 4% were Child C, 64% exhibited previous variceal bleeding and 66% were previously endoscopic treated. The endoscopic parameters, presence or absence of mosaic-like pattern, red point lesions and cherry-red spots were associated with high inter-observer reliability and high specificity for diagnosing Portal Hypertensive Gastropathy. Sensitivity, specificity and reliability for the diagnosis of PHG (%) were as follows: mosaic-like pattern (100; 92.21; High); fine pink speckling (56; 76.62; Unsatisfactory); superficial reddening (69.57; 66.23; Unsatisfactory); red-point lesions (47.83; 90.91; High); cherry-red spots (39.13; 96.10; High); isolated red marks (43.48; 88.31; High); and confluent red marks (21.74; 100; Unsatisfactory). Antral elevated erosive gastritis exhibited high reliability and high specificity with respect to the presence of portal hypertension (92%) and the diagnosis of portal hypertensive gastropathy (88.31%). CONCLUSION: The most suitable endoscopic criteria for the diagnosis of PHG were mosaic-like pattern, redpoint lesions and cherry-red spots with no subdivisions,which were associated with a high rate of inter-observer reliability. | George Fred Soares de Macedo Fabio Gon alves Ferreira Maurício Alves Ribeiro Luiz Arnaldo Szutan Mauricio Saab Assef Lucio Giovanni Battista Rossini | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 9 |
| 2 | Acute pancreatitis complicated with splenic rupture: A case report显示文摘Atraumatic splenic rupture is an uncommon complication of acute pancreatitis. This report describes the case of a 30-year-old man with acute pancreatitis and splenic vein thrombosis complicated by splenic rupture. The patient was admitted to the emergency department with pain in the upper abdomen that had been present for six hours and was associated with vomiting and sweating. He was diagnosed with acute pancreatitis of alcoholic etiology. Upon computed tomography(CT) of the abdomen, the pancreatitis was scored as Balthazar C grade, and a suspicious area of necrosis affecting 30% of the pancreas with splenic vein thrombosis was revealed. Seventytwo hours after admission, the patient had significant improvement in symptoms. However, he showed clinical worsening on the sixth day of hospitalization, with increasing abdominal distension and reduced hemoglobin levels. A CT angiography showed a large amount of free fluid in the abdominal cavity, along with a large splenic hematoma and contrast extravasation along the spleen artery. The patient subsequently underwent laparotomy, which showed hemoperitoneum due to rupture of the splenic parenchyma. A splenectomy was then performed, followed by ultrasound-guided percutaneous drainage. | Bruno L Hernani Pedro C Silva Ricardo T Nishio Henrique C Mateus José C Assef Tercio De Campos | 2015 | World Journal of Gastrointestinal Surgery2015，7，9： | 2 |
| 3 | Imatinib resistance in multidrug-resistant K562 human leukemic cells显示文摘 | Assef Y Rubio F Colo G | 2009 | Leuk Res2009，33，5： | 1 |
| 4 | Improvement of atherosclerotic markers in non-diabetic patients after bariatric surgery显示文摘 | Saleh MH Bertolami MC Assef JE | 2012 | Obes Surg2012，22，11： | 1 |
| 5 | Relevance of endoscopic ultra-sound in the management of esophagus cancer therapy显示文摘 | Assef M Rossini L Rossini L | 2014 | Endosc Ultrasound2014，3，1： | 1 |
| 6 | Imatinib resistance in multidrug-resistant K562 human leukemic cells显示文摘 | Yanina Assef Fernanda Rubio Georgina Coló Silvana del Mónaco Mónica A. Costas Basilio A. Kotsias | 2008 | Leukemia Research2008，，5： | 1 |
| 7 | lmatinib resistance in multidrugresistant K562 human leukemic cells显示文摘 | Assef Y Rubio F Colo G | 2009 | Leukemia Res2009，33，5： | 1 |
| 8 | Percut aneous closure of atrial septal defect:The role of transesophageal echocardiography 显示文摘 | Pedra SR Pedra CA Assef JE | 1999 | ArqBras Cardiol1999，72，1： | 1 |
| 9 | Topical anti - inflammatory effect of hypocholesterolaemic drugs 显示文摘 | Bracht L Caparroz - Assef SM Magon TFS | 2011 | J Pharm Pharmacol2011，63，7： | 1 |
| 10 | A progrmnmable FPGA-based 8-channel arbitrary waveform generator for medical ultrasound research activities 显示文摘 | ASSEF A A MAIA J M SCHNEIDER F K | 2012 | Annual In- ternational Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)2012，，： | 1 |
| 11 | Effect of esophagogastric devascularization with splenectomy on schistossomal portal hypertension patients' immunity显示文摘 | Ferreira FG Forte WC Assef JC | 2007 | Arq Castroenterol2007，44，1： | 1 |
| 12 | Percutaneous closure of atrial septal de fect: the role of transesophageal echocardiography显示文摘 | Pedra SR Pedra CA Assef JE | 1999 | Ara Bras Cardiol1999，72，1： | 1 |
| 13 | Mechanical dyssynchrony is similar in different patterns of left bundle-branch block 显示文摘 | Barretto RB Piegas LS Assef JE | 2013 | Arq Bras Cardiol2013，101，5： | 1 |
| 14 | Imatinib resistance in multidrug-resistant K562 human leukemic cells显示文摘 | Assef Y Rubio F Colo G | 2009 | Leuk Res2009，33，5： | 1 |
| 15 | Improvement of atherosclerotic markers in non-diabetic patients after bariatric surgery显示文摘 | Saleh MH Bertolami MC Assef JE | 2012 | Obes Surg2012，22，11： | 1 |
| 16 | Classification of severity of acute pancreatitis 显示文摘 | De Campos T Parreira JG Assef JC | 2013 | Rev Col Bras Cir2013，40，2： | 1 |
| 17 | Characterization of the epithelial sodium channel in human pre-eclampsia syncytiotrophoblast显示文摘 | del Monaco S Assef Y Damiano A etal | 2006 | Medicina (B Aires)2006，66，1： | 1 |
| 18 | Epithelial sodium channel in a human trephoblast cell line (bewo) 显示文摘 | Del Mrnaco S Assef Y Kotsias BA | 2008 | J Membrane Biol2008，223，3： | 1 |
| 19 | Artificial neuralnetworks for single phase fault detection in resonantgrounded power distribution systems显示文摘 | ASSEF Y BASTAAD P MEUNIE M | 1996 | IEEE PES Trans-mission and Distribution Conference1996，，： | 1 |
| 20 | Characterization of the epithelial sodium channel in human pre-eclampsia syncytiotrophoblast 显示文摘 | Del Mrnaco S Assef Y Damiano A | 2006 | Medicina (B Aires)2006，66，1： | 1 |
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