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| 1 | A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease显示文摘AIM:To compare the efficacy of the proton-pump inhibitor,rabeprazole,with that of the H 2-receptor antagonist,ranitidine,as on-demand therapy for relieving symptoms associated with non-erosive reflux disease(NERD).METHODS:This is a single center,prospective,randomized,open-label trial of on-demand therapy with rabeprazole(group A) vs ranitidine(group B) for 4 wk.Eighty-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease(GERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the study.Patients in group A(n = 44) were allowed a maximum rabeprazole dose of 20 mg twice daily,while those in group B(n = 39) were allowed a maximum ranitidine dose of 300 mg twice daily.Efficacy was assessed by patient evaluation of global symptom relief,scores of the SF-36 quality of life(QoL) questionnaires,total number of pills used,and number of medication-free days.RESULTS:Among the 83 patients who were enrolled in the study,76 patients(40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk trial.Baseline characteristics were comparable between both groups.After 4 wk,there was no significant difference in the subjective global symptom relief between the rabeprazole and the ranitidine groups(71.4% vs 65.4%,respectively;P = 0.9).There were no statistically significant differences between mean cumulative scores of the SF-36 QoL questionnaire for the two study groups(rabeprazole 22.40 ± 27.53 vs ranitidine 17.28 ± 37.06;P = 0.582).There was no significant difference in the mean number of pills used(rabeprazole 35.70 ± 29.75 vs ranitidine 32.86 ± 26.98;P = 0.66).There was also no statistically significant difference in the mean number of medication-free days between both groups.CONCLUSION:Rabeprazole has a comparable efficacy compared to ranitidine when given on-demand for the treatment of NERD.Both medications were associated with improved quality of life. | Abdallah A Kobeissy Jana G Hashash Faek R Jamali Assaad M Skoury Reham Haddad Sarah El-Samad Rami Ladki Rola Aswad Assaad M Soweid | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 2 | Posterior lingual lidocaine: A novel method to improve tolerance in upper gastrointestinal endoscopy显示文摘AIM: To evaluate the effect of posterior lingual lidocaine swab on patient tolerance to esophagogastro-duodenoscopy, the ease of performance of the procedure, and to determine if such use will reduce the need for intravenous sedation. METHODS: Eighty patients undergoing diagnostic esophagogastroduodenoscopy in a tertiary care medical center were randomized to either lidocaine swab or spray. Intravenous meperidine and midazolam were given as needed during the procedure. RESULTS: Patients in the lidocaine swab group (SWG) tolerated the procedure better than those in the spray group (SPG) with a median tolerability score of 2 (1, 4) compared to 4 (2, 5) (P < 0.01). The endoscopists encountered less diffi culty performing the proceduresin the SWG with lower median difficulty scores of 1 (1, 5) compared to 4 (1, 5) in the SPG (P < 0.01). In addition, the need for intravenous sedation was also lower in the SWG compared to the SPG with fewer patients requiring intravenous sedation (13/40 patients vs 38/40 patients, respectively, P < 0.01). The patients in the SWG were more satisfi ed with the mode of local anesthesia they received as compared to the SPG. In addition, the endoscopists were happier with the use of lidocaine swab. CONCLUSION: The use of a posterior lingual lidocaine swab in esophagogastroduodenoscopy improves patient comfort and tolerance and endoscopist satisfaction and decreases the need for intravenous sedation. | Assaad M Soweid Shadi R Yaghi Faek R Jamali Abdallah A Kobeissy Michella E Mallat Rola Hussein Chakib M Ayoub | 2011 | World Journal of Gastroenterology2011，17，47： | 2 |
| 3 | Use of anti tumor necrosis factor-alpha monoclonal antibody for ulcerative jejunoileitis显示文摘Ulcerative jejunoileitis is an uncommon clinical syndrome consisting of abdominal pain,weight loss associated with diarrhea,and multiple inflammatory ulcerations and strictures of the small bowel.Ulcerative jejunoileitis can complicate established celiac disease or develop in patients de novo.Increased levels of tumor necrosis factor-alpha(TNF-α) in the small intestine of patients with untreated celiac disease are associated with a role in the immune pathogenesis of this disorder.No specific therapy has been shown to change the course of ulcerative jejunoileitis.We report a case of severe ulcerative jejunoileitis previously unresponsive to traditional therapies,including high dose corticosteroids and cyclosporine.The patient had a dramatic resolution of symptoms and a complete normalization of endoscopic findings after anti-TNF-α monoclonal antibody,infliximab(Remicade). | Gulseren Seven Adel Assaad Thomas Biehl Richard A Kozarek | 2012 | World Journal of Gastroenterology2012，18，36： | 2 |
| 4 | Risk of pneumonitis in breast cancer patients treated with radiation therapy and combination chemotherapy with paclitaxel 显示文摘 | Taghian AG Assaad SI Niemierko A | 2001 | J Natl Cancer Inst2001，93，23： | 1 |
| 5 | Experimental study of the A0 and SO lamb waves interactionwith symmetrical notches 显示文摘 | Benmeddour F B Grondel S Assaad J A | 2009 | Ultrasonics2009，49，2： | 1 |
| 6 | Risk of pneumonitis in breast cancer padents treated with radiation therapy and combination chemotherapy with paclitaxel显示文摘 | Taghian AG Assaad SI Niemierko A | 2001 | J Nail Cancer Inst2001，93，23： | 1 |
| 7 | Closely related receptor complexes differ in their ABA selectivity and sensitivity 显示文摘 | Szostkiewicz I Richter K Kepka M Demmel S Na Y Korte A Assaad F F Christmann A Grill E | 2010 | Plant Journal2010，61，1： | 1 |
| 8 | Fluid management in thoracic surgery显示文摘 | Assaad S Popescu W Perrino A | 2013 | Curr Opin Anaesthesiol2013，26，1： | 1 |
| 9 | Work group report:oral food challenge testing显示文摘 | Nowak-Wegrzyn A Assaad HA Bahna LS | 2009 | J Allergy Clin Immunol2009，123，6： | 1 |
| 10 | Nox4 Nadph oxidase mediates peroxynitrite-dependent uncoupling of endothelial Nitric-oxide synthase and fibronectin expression in response to angiotensin II: ROLE of mitochondrial reactive oxygen species显示文摘 | Doug YL Fabien W Assaad A | 2013 | J Biol Chem2013，288，28： | 1 |
| 11 | Effect of clinker grinding aids on flow of cement-based materials 显示文摘 | Joseph J Assaad Camille A Issa | 2014 | Cement and Concrete Research2014，9，63： | 1 |
| 12 | Forenaic analysis of 1095: Modeling and verifieation 显示文摘 | MOHAMED S ALI R A ASSAAD S | 2009 | Knowledge -Based Systems2009，20，7： | 1 |
| 13 | Effect of superoxide dismutase on a rabbit model of chronic allergic asthma显示文摘 | ASSAAD A H BRALLARD E T SEBASTIAN K D | 1998 | Ann Allergy Asthma Immunol1998，80，2： | 1 |
| 14 | Risk of pneumonitis in breast cancer patients treated with radiation therapy and combination chemotherapy with paclitaxel显示文摘 | Taghian AG Assaad SI Niemierko A | 2001 | J Natl Cancer Inst2001，93，： | 1 |
| 15 | Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel显示文摘 | Boyce JA Assaad A Burks AW | 2010 | J Allergy Clin Immunol2010，126，6： | 1 |
| 16 | Real-time three-dimensional fetal echocardiography using matrix probe显示文摘 | Philippe A Yves D Assaad T | 2005 | Prenat Diagn2005，25，2： | 1 |
| 17 | Metal removalthrough synergic coagulation-flocculation using an optimizedchitosan-montmorillonite system显示文摘 | ASSAAD E AZZOUZ A NISTOR D | 2007 | Applied Clay Science2007，37，34： | 1 |
| 18 | Fluid management in thoracic surgery显示文摘 | Assaad S l:'opesca W IYn'ino A | 2013 | Cull' Opin Anaesthesiol2013，26，1： | 1 |
| 19 | Branchial cleftlike cysts of the thyroid显示文摘 | Ko AB Assaad A Carty SE | 2006 | Am J Otolaryngol2006，27，2： | 1 |
| 20 | The profile of acinie cell carcinoma after recognition of mammary analog secretory carcinoma 显示文摘 | Chiosea S I Griffith C Assaad A | 2012 | AmJSurgPathol2012，36，3： | 1 |
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