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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 血流介导的血管舒张,硝酸甘油诱导的血管舒张,基线肱动脉直径,充血剪切应力与心血管病危险因素之间的相关性显示文摘血流介导的血管舒张功能(flow-mediated vasodilation,FMD)已被用于评估内皮功能。充血性剪切应力(hyperemic shear stress,HSS,一种FMD的刺激因素)、硝酸甘油诱导的血管舒张(nitroglycerine-induced vasodilation,NID,非内皮依赖性血管舒张指数)以及基线肱动脉直径(brachial artery diameter,BAD)也参与血管舒张反应。 | 刘青 叶鹏 Maruhashi T Iwamoto Y Kajikawa M Oda N Kishimoto S Matsui S Hashimoto H Aibara Y Yusoff FM Hidaka T Kihara Y Chayama K Noma K Nakashima A Goto C Hida E Higashi Y | 2018 | 中华高血压杂志2018，26，1： | 5 |
| 3 | Endothelin-1 and nitric oxide synthase in short rebound reaction to short exposure to inhaled nitric oxide显示文摘 | Chen LN He H Enrigue FM | 2001 | Am J Physiol Heart Circ Physiol2001，281，1： | 1 |
| 4 | Provider assessment of adherence to HIV antiretroviral therapy显示文摘 | Bangsberg DR Hecht FM Clague H | 2001 | J Acquir Immune Defic Syndr2001，26，： | 1 |
| 5 | The wide field multifocal electroretinogram reveals retinal dysfunction in early retinitis pigmentosa显示文摘 | Dolan FM Parks S Hammer H Keating D | 2002 | Br J Ophthalmol2002，86，4： | 1 |
| 6 | The up-regulation of type I plasminogen activator inhibitor in human gingival fibroblasts stimulated with cyclosporin A 显示文摘 | Lin H J Tsai CH Huang FM | 2007 | J Periodontal Res2007，42，1： | 1 |
| 7 | Higher prevalence of periodic limb movements of sleep in patients with history of stroke 显示文摘 | Coelho FM Georgsson H Narayansingh M | 2010 | J Clin Sleep Med2010，6，5： | 1 |
| 8 | Dicer-de pendent microRNAs control maturation, function, and ma intenance of Langerhans cells in vivo 显示文摘 | Kuipers H Schnorfeil FM Fehling HJ etal | 2010 | J Immunol2010，185，1： | 1 |
| 9 | Carotid atherosclerosis and cardiovascular risk factors in hemodialysis and peritoneal dialysis patients显示文摘 | Yilmaz FM Akay H Duranay M | 2007 | Clin Biochem2007，40，18： | 1 |
| 10 | Course of platelet aetivationand platelet leukoeyte interaetionin ce-rebrovaseular isehemia显示文摘 | Patrik H Suzanne FM | 2006 | Stroke2006，37，9： | 1 |
| 11 | Coltiviruses and Seadomaviatses in North American, Europe, and Asia显示文摘 | Attoui H Mohd Jaafar FM de Micco P | 2005 | Emerg In- fect Dis2005，1，11： | 1 |
| 12 | Ghrelin and the hyposomatotropism of obesity 显示文摘 | Lindeman JH Pijl H Van Dielen FM | 2002 | Obes Res2002，10，11： | 1 |
| 13 | Tumor necrosis factor (TNF) receptor type 2 mediates thymocyte proliferation inde pendently of TNF receptor type 1显示文摘 | Grell M Becke FM Wajant H | 1998 | European Journal of Immu nology1998，28，1： | 1 |
| 14 | Liaoning virus, a new Chinese seadornavirus that replicates in transformed and embryon- ic mammalian cells 显示文摘 | Attoui H Jaafar FM Belhouchet M | 2006 | J Gen Virol2006，，： | 1 |
| 15 | Fouling characterization in membrane bioreactors显示文摘 | Bouhabila E H A'fm R B Buisson H 2001 | 2001 | Separation and Purification Technology2001，2223，： | 1 |
| 16 | Delayed graft function: predictive factors and impact on outcome in living-related kidney transplantations显示文摘 | Seael FM Karakatali H Moray G | 1998 | Ren Fail1998，20，4： | 1 |
| 17 | IGF2 imprinting: a potential marker of colorectal cancer risk显示文摘 | Cui H Cruz-Correa M Giardiello FM | 2003 | Science2003，299，5613： | 1 |
| 18 | Loss of imprinting of insulin growth factor II gene: A potential heritable bio-marker for colon neoplasia predisposition显示文摘 | Cruz-Correa M Cui H Giardiello FM | 2004 | Gastroenterology2004，126，： | 1 |
| 19 | Metastases but not cardiovascular mortality reduces life expectancy following surgical resection of apparently benign pheochromocytoma显示文摘 | Timmers H J Brouwers FM Hermus AR | 2008 | Endocr Relat Cancer2008，15，4： | 1 |
| 20 | Identification of metalloprotease/disintegrins in Xenopus laevis testis with a potential role in fertilization显示文摘 | Kratzschmar J Cai H | 1997 | Dev Biol1997，186，2： | 1 |
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