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| 1 | Rare localization of extrarenal nephroblastoma in 1-month-old female infant显示文摘 | Armanda V Culic S Pogorelic Z | 2012 | JOURNAL OF PEDIATRIC UROLOGY2012，，04： | 1 |
| 2 | Rare localization of extrarenal nephroblastoma in 1 -month-old female infant 显示文摘 | Armanda V Culic S Pogorelic Z | 2012 | J Pediatr Urol2012，8，4： | 1 |
| 3 | Rare localization of extrarenal nephroblastoma in 1-month old female infant显示文摘 | Armanda V Culi S Pogorelic Z | | J Pediatr Urol0，8，4： | 1 |
| 4 | Role of (myo)fibroblasts in the development of vascular and connective tissue structure of the C38 colorectal cancer in mice显示文摘Background:It remains unclear if the vascular and connective tissue structures of primary and metastatic tumors are intrinsically determined or whether these characteristics are defined by the host tissue.Therefore we examined the microanatomical steps of vasculature and connective tissue development of C38 colon carcinoma in different tissues.Methods:Tumors produced in mice at five different locations(the cecal wall,skin,liver,lung,and brain)were ana-lyzed using fluorescent immunohistochemistry,electron microscopy and quantitative real-time polymerase chain reaction.Results:We found that in the cecal wall,skin,liver,and lung,resident fibroblasts differentiate into collagenous matrix-producing myofibroblasts at the tumor periphery.These activated fibroblasts together with the produced matrix were incorporated by the tumor.The connective tissue development culminated in the appearance of intratumoral tissue columns(centrally located single microvessels embedded in connective tissue and smooth muscle actin-expressing myofibroblasts surrounded by basement membrane).Conversely,in the brain(which lacks fibroblasts),C38 metasta-ses only induced the development of vascularized desmoplastic tissue columns when the growing tumor reached the fibroblast-containing meninges.Conclusions:Our data suggest that the desmoplastic host tissue response is induced by tumor-derived fibrogenic molecules acting on host tissue fibroblasts.We concluded that not only the host tissue characteristics but also the tumor-derived fibrogenic signals determine the vascular and connective tissue structure of tumors. | Edina Bugyik Vanessza Szabó Katalin Dezső András Rókusz Armanda Szücs Péter Nagy József Tóvári Viktória László Balázs Döme Sándor Paku | 2018 | Cancer Communications2018，38，1： | 1 |
| 5 | AntiCD20 monoclonal antibody (Rituximab) for therapy of mediastinal CD20-positive large Bcell non-Hodgkin lymphoma with a local tumor extension into the lung of a 10-year-old girl 显示文摘 | Culic S Culic V Armanda V | 2003 | Pediatr HematolOncol2003，20，4： | 1 |
| 6 | (肌)成纤维细胞在C38结直肠癌小鼠模型血管和结缔组织结构发展中的作用显示文摘背景与目的关于原发和转移性肿瘤的血管和结缔组织结构是由本身决定还是由宿主组织决定,目前尚不清楚。因此,我们研究了不同组织中C38结直肠癌血管和结缔组织发展的显微解剖过程。方法采用免疫荧光染色、电镜和实时定量聚合酶链反应等方法对小鼠盲肠壁、皮肤、肝脏、肺和大脑5个不同部位生成的肿瘤进行分析。结果我们发现在盲肠壁、皮肤、肝脏和肺的成纤维细胞分化成胶原蛋白基质,在肿瘤周围产生肌成纤维细胞。这些活化的成纤维细胞和生成的基质被肿瘤吸收利用。结缔组织的发展最终引起瘤内组织柱的出现(位于中心位置的单个微血管包埋在结缔组织和表达平滑肌肌动蛋白的肌成纤维细胞中,最外围由基底膜包围)。相反,在缺乏成纤维细胞的大脑中,仅当增生的肿瘤接触到含有成纤维细胞的脑膜时,C38转移才能诱导血管生成的促结缔组织增生性纤维柱的形成。结论我们的数据表明,作用于宿主组织成纤维细胞的肿瘤源性纤维生成分子诱导了促结缔组织增生的宿主组织反应。我们认为宿主组织特征和肿瘤来源的纤维生成信号共同决定了肿瘤的血管和结缔组织的结构。 | Edina Bugyik Vanessza Szabó Katalin Dezso András Rókusz Armanda Szücs Péter Nagy József Tóvári Viktória László Balázs Dome Sándor Paku | 2019 | 癌症2019，38，3： | 0 |
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