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| 1 | Imaging of liver cancer显示文摘Improvements in imaging technology allow exploitation of the dual blood supply of the liver to aid in the identif ication and characterisation of both malignant and benign liver lesions. Imaging techniques available include contrast enhanced ultrasound, computed tomography and magnetic resonance imaging. This review discusses the application of several imaging techniques in the diagnosis and staging of both hepatocellular carcinoma and cholangiocarcinoma and outlines certain characteristics of benign liver lesions. The advantages of each imaging technique are highlighted, while underscoring the potential pitfalls and limitations of each imaging modality. | Ben Ariff Claire R Lloyd Sameer Khan Mohamed Shariff Andrew V Thillainayagam Devinder S Bansi Shahid A Khan Simon D Taylor-Robinson Adrian KP Lim | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 2 | Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance显示文摘Objective: Lack of effective therapies remains a problem in the treatment of oral squamous cell carcinoma(OSCC), especially in patients with advanced tumors. OSCC development is driven by multiple aberrancies within the cell cycle pathway, including amplification of cyclin D1 and loss of p16. Hence, cell cycle inhibitors of the CDK4/6-cyclin D axis are appealing targets for OSCC treatment. Here, we determined the potency of palbociclib and identified genetic features that are associated with the response of palbociclib in OSCC.Methods: The effect of palbociclib was evaluated in a panel of well-characterized OSCC cell lines by cell proliferation assays and further confirmed by in vivo evaluation in xenograft models. PIK3CA-mutant isogenic cell lines were used to investigate the effect of PIK3CA mutation towards palbociclib response.Results: We demonstrated that 80% of OSCC cell lines are sensitive to palbociclib at sub-micromolar concentrations.Consistently, palbociclib was effective in controlling tumor growth in mice. We identified that palbociclib-resistant cells harbored mutations in PIK3CA. Using isogenic cell lines, we showed that PIK3CA mutant cells are less responsive to palbociclib as compared to wild-type cells with concurrent upregulation of CDK2 and cyclin E1 protein levels. We further demonstrated that the combination of a PI3 K/mTOR inhibitor(PF-04691502) and palbociclib completely controlled tumor growth in mice.Conclusions: This study demonstrated the potency of palbociclib in OSCC models and provides a rationale for the inclusion of PIK3CA testing in the clinical evaluation of CDK4/6 inhibitors and suggests combination approaches for further clinical studies. | Nur Syafinaz Zainal Bernard Kok Bang Lee Zheng Wei Wong Iuan Sheau Chin Pei San Yee Chai Phei Gan Kein Seong Mun Zainal Ariff Abdul Rahman J. Silvio Gutkind Vyomesh Patel Sok Ching Cheong | 2019 | Cancer Biology & Medicine2019，16，2： | 3 |
| 3 | Direct fermentation of gelatinized sago starch to acetone-butanol-ethanol by Clostridium acetobutylicum显示文摘 | Madihah M Ariff A Sahaid K | 2001 | World Journal of Microbiology and Biotechnology2001，17，6： | 1 |
| 4 | A study of hysteria among youth in a secondary school in Malaysia 显示文摘 | Sham FM Hamjah SH Ariff MI | 2012 | Advances in Natural and Applied Sciences2012，6，4： | 1 |
| 5 | Is there a role for free breathing non-contrast steady-state free precession renal MRA imaging for assessing live donors? A preliminary study显示文摘 | Laurence I Ariff B Quest RA | 2012 | Br J Radiol2012，85，1016： | 1 |
| 6 | Production of cellulase by a wild strain of Chaetomium globosum using delignified oil palm empty-friut-bunch fiber as substrate显示文摘 | Umikalsom M S Ariff A B Shamsuddin Z H | 1997 | Appl Microbiol1997，47，： | 1 |
| 7 | Assessment of severe reperfusion injury with T2 * cardiac MRI in patients with acute myocardial infarction 显示文摘 | O'Regan DP Ariff B Neuwirth C | 2010 | Heart2010，96，23： | 1 |
| 8 | Optimization of enzymaticsynthesis of palm based kojic acid ester using re sponse surfacemethodology显示文摘 | ASHAN S E MIGANAD T ARIFF A | 2009 | J Oleo Sci2009，58，10： | 1 |
| 9 | Cell viability ofmi- croencapsulated Bifidobacterium aninalis subsp, lactis under freeze-dry- ing, storage and gastrointestinal tract simulation conditions显示文摘 | SHAMEKHI F SHUHAIMI M ARIFF A | 2013 | Folia microbiologica2013，58，2： | 1 |
| 10 | Differential geomet- ric guidance based on the involute of the target ~s trajectory 显示文摘 | Ariff O Zbikowski R Tsourdos A | 2005 | Journal of Guidance Control and Dynamics2005，28，5： | 1 |
| 11 | Cost and Profit Efficiency of Chinese Banks: A Non-parametric Analysis 显示文摘 | Ariff M Can L | 2008 | China Economic Review2008，19，2： | 1 |
| 12 | Analysis of complex flow and the relationship between blood pressure, wall 显示文摘 | Augst A D Ariff B McG Thorn S A | 2007 | Physiol Heart Circ Physiol2007，293，2： | 1 |
| 13 | Establishment of human endometriual cell cultures 显示文摘 | Ariff B Bain G Ngphd L | 1998 | Human Reprod1998，3，6： | 1 |
| 14 | Effect of foaming temperature and rubber grades on properties of nature rub- ber foams显示文摘 | Ariff Z M Zakaria Z Tay L H | 2008 | J Appl Polym Sci2008，107，4： | 1 |
| 15 | Improvements of GC and HPLC analyses in solvent(ccetone-butanol-ethanol) fermentation by Clostridium saccharobutylicum using a mixture of starch and glycerol as carbon source 显示文摘 | LIEW SHIAU TSUEY ARBAKARIYA BIN ARIFF ROSFARIZAN Mohamad | 2006 | Biotechnotogy and Bioprocess Engineering2006，11，4： | 1 |
| 16 | Correlation between the acoustic and dynamic mechanical properties of natural rubber foam: Effect of foaming temperature显示文摘 | Najib N N Ariff Z M Bakar A A | | 0，，： | 1 |
| 17 | Coherency identification in interconnected power system: An independent component analysis approach显示文摘 | Ariff M A M Pal B C | 2013 | IEEE Transaction on Power Systems2013，28，2： | 1 |
| 18 | Correlation be- tween the acoustic and dynamic mechanical properties of na- tural rubber foam: Effect of foaming temperature显示文摘 | Najib N N Ariff Z M Bakar A A | 2011 | Mater Des2011，32，2： | 1 |
| 19 | Gray-level co-occurrence matrix bone fracture detection 显示文摘 | CHAI H Y WEE L K SWEE T T SALLEH S H ARIFF A | 2011 | American Journal of Applied Sciences2011，8，： | 1 |
| 20 | The performance of a glass bead shaking technique for the disruption of Escherichia coli ee]ls 显示文摘 | RAMANAN R N LING T C ARIFF A B | 2008 | Bioteehno] Bioproe Eng2008，13，5： | 1 |
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