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| 1 | Hepatic encephalopathy: Ever closer to its big bang显示文摘Hepatic encephalopathy(HE) is a neuropsychiatric disorder that commonly complicates the course of patients with liver disease. Despite the fact that the syndrome was probably first recognized hundreds of years ago, the exact pathogenesis still remains unclear. Minimal hepatic encephalopathy(MHE) is the earliest form of HE and is estimated to affect more that 75% of patients with liver cirrhosis. It is characterized by cognitive impairment predominantly attention, reactiveness and integrative function with very subtle clinical manifestations. The development of MHE is associated with worsen in driving skills, daily activities and the increase of overall mortality. Skeletal muscle has the ability to shift from ammonia producer to ammonia detoxifying organ. Due to its large size, becomes the main ammonia detoxifying organ in case of chronic liver failure and muscular glutaminesynthase becomes important due to the failing liver and brain metabolic activity. Gut is the major glutamine consumer and ammonia producer organ in the body. Hepatocellular dysfunction due to liver disease, results in an impaired clearance of ammonium and in its interorgan trafficking. Intestinal bacteria, can also represent an extra source of ammonia production and in cirrhosis, small intestinal bacterial overgrowth and symbiosis can be observed. In the study of HE, to get close to MHE is to get closer to its big bang; and from here, to travel less transited roads such as skeletal muscle and intestine, is to go even closer. The aim of this editorial is to expose this road for further and deeper work. | Pablo A Souto Ariel R Marcotegui Lisandro Orbea Juan Skerl Juan Carlos Perazzo | 2016 | World Journal of Gastroenterology2016，22，42： | 6 |
| 2 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 3 | Pericytes synthesize renin显示文摘AIM: To investigate renin expression in pericytes during normal kidney development and after deletion of angiotensinogen, the precursor for all angiotensins.METHODS: We examined the distribution of renin expressing cells by immunoshistochemistry in the interstitial compartment of wild type(WT) and angiotensinogen deficient(AGT-/-) mice at different developmental stages from embryonic day 18(E18: WT, n = 4; AGT-/-, n = 5) and at day 1(P1: WT, n = 5; AGT-/-, n = 5), 5(P5: WT, n = 7; AGT-/-, n = 8), 10(P10: WT, n = 3; AGT-/-, n = 5), 21(P21: WT, n = 7; AGT-/-, n = 5), 45(P45: WT, n = 3; AGT-/-, n = 3), and 70(P70: WT, n = 2; AGT-/-, n = 2) of postnatal life. We quantified the number of pericytes positive for renin at all the developmental stages mentioned above and comparedthe results of AGT-/- mice to their WT counterparts.RESULTS: In WT mice, renal interstitial pericytes synthesize renin in early life supporting a lineage relationship with renin cells in the vasculature. The number of pericytes positive for renin per area of 0.32 mm2(density) in WT mice was maintained from fetal life till weaning age(E18 = 4.25 ± 0.63, P1 = 3.75 ± 0.48, P5 = 3.75 ± 0.48, P10 = 4 ± 0.71, P21 = 3.8 ± 0.58) and markedly decreased in adult life(P45 = 1.2 ± 0.37, P70 = 0.8 ± 0.20). On the other hand, in AGT-/- mice the density of pericytes expressing renin was not significantly different from WT mice at E18 and P1: E18 = 5.75 ± 0.50 vs 4.25 ± 0.63(P = 0.106), P1 = 9.25 ± 3.50 vs 3.75 ± 0.48(P = 0.175) but significantly increased from P5 till P70: P5 = 38.25 ± 5 vs 3.75 ± 0.48(P = 0.0004), P10 = 173 ± 7.50 vs 4 ± 0.70(P = 5.24567 × 10-7), P21 = 83 ± 6.70 vs 3.8 ± 0.58(P = 2.97358 × 10-6), P45 = 49 ± 3.50 vs 1.2 ± 0.37(P = 8.18274 x 10-7) and P70 = 17.8 ± 2.30 vs 0.8 ± 0.20(P = 3.51151 × 10-5). The AGT-/- mice showed a marked increase in the number of pericytes per field studied starting from P5, reaching its peak at P10, and then a gradually decreasing until P70. CONCLUSION: Interstitial pericytes synthesize renin during development and the number of renin-expressing pericytes increases in response to a homeostatic threat imposed early in life such as lack of angiotensinogen. | Alison C Berg Catalina Chernavvsky-Sequeira Jennifer Lindsey R Ariel Gomez Maria Luisa S Sequeira-Lopez | 2013 | World Journal of Nephrology2013，2，1： | 2 |
| 4 | Feedback links between economy-wide and farm-level policies : With application to irrigation water management in Morocco 显示文摘 | Terry R Ariel D Yacov T | 2005 | Journal of Policy Modeling2005，27，： | 1 |
| 5 | A monthly effect in stock returns显示文摘 | ARIEL R | 1987 | Journal of Financial Economics1987，，18： | 1 |
| 6 | Effect of heat treatment on strawberry fruit damage and oxidative metabolism during storage显示文摘 | Ariel R V Gustavo A M Alicia R C | 2006 | Postharvest Biolog'' and Teclmolo:v2006，40，： | 1 |
| 7 | Profound Development Dyscalculia: Evidence for a Cardinal/ordinal Skills Acquisition Device显示文摘 | Ta'ir J Brezner B Ariel R | 1997 | Brain and Cognition1997，35，2： | 1 |
| 8 | Long-term cognitive outcomes of a cohort of children with cryptogenic infantile spasms treated with high-dose adrenocor-ticotropic hormone显示文摘 | KIVITY S LERMAN P ARIEL R | 2004 | Epilepsia2004，45，3： | 1 |
| 9 | Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac per- formance, or the response to volume infusion in normal subjects显示文摘 | Kumar A Ariel R Bunnell E | 2004 | Grit Care Med2004，32，1： | 1 |
| 10 | EvMuating water institutions and water sector performance 显示文摘 | MARIA S R ARIEL D | 1999 | World Bank Technical Pa- pers1999，，447： | 1 |
| 11 | Frequent apoptosis in human kidneys after acute renal hypoperfusion 显示文摘 | Jaffe R Ariel I Beeri R | 1997 | Exp Nephrol1997，5，5： | 1 |
| 12 | A monthly effect in stock returns显示文摘 | Ariel R | 1987 | Journal of Financial Economics1987，18，： | 1 |
| 13 | Stearoyl-Co A desaturase is involved in the control of proliferation,anchorage-independent growth,and survival in human transformed cells显示文摘 | Natalia Scaglia Ariel Igal R | 2005 | J Biol Chem2005，280，25： | 1 |
| 14 | Reducing infections among women undergoing cesarean section in Colombia by means of continuous quality improvement methods 显示文摘 | Michelle W Jose MF Ariel I R | 2001 | Arch Intern Med2001，161，19： | 1 |
| 15 | A view of cloud computing显示文摘 | MICHAEL A ARMANDO F REAN Q ANTHONY D J RANDY K ANDY K GUNHO L DAVID P ARIEL R ION S MATEI Z | 2010 | Communications of the ACM2010，53，4： | 1 |
| 16 | Inhibitor design by wrapping packing defects in HIV-1 proteins显示文摘 | Ariel F Kristina R Ridgway S | 2004 | PNAS2004，101，11： | 1 |
| 17 | Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1显示文摘 | Rabinovich G A Ariel A Hershkoviz R | 1999 | Immunology1999，97，1： | 1 |
| 18 | Long - term cognitive out comes of a cohort of children with cryptogenic infantile spasms treated with high - dose adrennocorticotropic hormone显示文摘 | Kivity S Lerman P Ariel R | 2004 | Epilepsia2004，45，3： | 1 |
| 19 | UV-Ctreatments reduce decay, retain quality andalleviate chillinginjury in pepper 显示文摘 | Ariel R V Carlos P Laura L | 2005 | PostharvestBiology and technology2005，35，： | 1 |
| 20 | Long term cognitive outcomes of a cohort of children with cryptogenic infantile spasms treated with high-dose adrenocorticotropic hormone显示文摘 | Lerman P Ariel R | 2004 | Epilepsia2004，45，： | 1 |
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