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| 1 | Evidence to suggest adoption of water exchange deservesbroader consideration:Its pain alleviating impact occurs in90%of investigators显示文摘AIM: To determine variations in colonoscopy real-time insertion pain among investigators using three different insertion techniques.METHODS: From March 2013 through June 2014, 18-85-year-old diagnostic and 50-70-year-old screening patients were enrolled at each center to on-demand sedation colonoscopy with water exchange(WE), water immersion(WI) and insufflation with air or CO2 for insertion and withdrawal [air or carbon dioxide(AICD)]. Data were aggregated for analysis. Primary outcome: Variations in real-time maximum insertion pain(0 = none, 1-2 = discomfort, 10 = worst).RESULTS: One thousand and ninety-one cases analyzed: WE(n = 371); WI(n = 338); AICD(n = 382). Demographics and indications were comparable. The WE group had the lowest real-time maximum insertion pain score, mean(95%CI): WE 2.8(2.6-3.0), WI 3.8(3.5-4.1) and AICD 4.4(4.1-4.7), P < 0.0005. Ninety percent of the colonoscopists were able to use water exchange to significantly decrease maximum insertion pain scores. One investigator had high insertion pain in all groups, nonetheless WE achieved the lowest real-time maximum insertion pain score. WE had the highest proportions of patients with painless unsedated colonoscopy(vs WI, P = 0.013; vs AICD, P < 0.0005); unsedated colonoscopy with only minor discomfort(vs AICD, P < 0.0005), and completion without sedation(vs AICD, P < 0.0005).CONCLUSION: Aggregate data confirm superiority of WE in lowering colonoscopy real-time maximum insertion pain and need for sedation. Ninety percent of investigators were able to use water exchange to significantly decrease maximum insertion pain scores. Our results suggest that the technique deserves consideration in a broader scale. | Sergio Cadoni Mauro Liggi Premysl Falt Stefano Sanna Mariangela Argiolas Viviana Fanari Paolo Gallittu Donatella Mura Maria L Porcedda Vit Smajstrla Matteo Erriu Felix W Leung | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 2 | An ATG repeat in the 3'-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance显示文摘 | PIZZUTI A ARGIOLAS A DIPAOLA R | 2002 | J Chn Endocrinol Metab2002，87，： | 1 |
| 3 | Central control of penile erection: role of the paraventricular nucleus of the hypothalamus 显示文摘 | Argiolas A Melis MR | 2005 | Prog Neurobiol2005，76，1： | 1 |
| 4 | A potymorphism(k121Q) of the human ghycoprotein PC-1 gene coding region is strongly associated with insulin resistance显示文摘 | PIZZUTI A FRITFTTLA L ARGIOLAS A | 1999 | Diabetes1999，48，9： | 1 |
| 5 | A Polymorphism(K121Q)of the Human Glycooprotein PC-1 Gene Coding Region is Strongly Associated with Insulin Resistance显示文摘 | PIZZUTI A FRITTITTA L ARGIOLAS A | 1999 | Diabetes1999，48，9： | 1 |
| 6 | The pharmacology and clinical pharmacokinetics of apomorphine SL显示文摘 | Argiolas A Hedlund H | 2001 | BJU Int2001，88，3： | 1 |
| 7 | Pelvic floor failure: MR imaging evaluation of anatomic and functional abnormalities显示文摘 | BITTI G T ARGIOLAS G M BALLICU N | 2014 | Radiographics2014，34，2： | 1 |
| 8 | A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance显示文摘 | Pizzuti A Frittitta L Argiolas A | 1999 | Diabetes1999，48，： | 1 |
| 9 | Central control of penile erection:role of the paraventricular nucleus of the hypothalamus显示文摘 | Argiolas A Melis MR | 2005 | Prog Nerrobio2005，76，1： | 1 |
| 10 | A polymorphism(K121Q) of the human glycopmtein PC-1gene coding region is strongly associated with insulin resistance 显示文摘 | Pizzuti A Frittitta L Argiolas A | 1999 | Diabetes1999，48，： | 1 |
| 11 | A polymorphism(K121Q)of the human glycoprotein PC-1 gene coding region is strongly associanted with insulin resistance显示文摘 | Pizzuti A Frittitta L Argiolas A | 1999 | Diabetes1999，48，9： | 1 |
| 12 | A polymorphism(K121Q)of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance显示文摘 | Pizzuti A Frittitta L Argiolas A | 1999 | Diabetes1999，48，： | 1 |
| 13 | A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance显示文摘 | Pizzuti A Frittitta L Argiolas A | 1999 | Diabetes1999，48，9： | 1 |
| 14 | A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance 显示文摘 | Frittitta L Argiolas A | 1999 | Diabetes1999，48，9： | 1 |
| 15 | ACTH- and alpha-MSH-induced grooming, stretching, yawning and penileerection in male rats: site of action in the brain and role ofmelanocortin receptors 显示文摘 | Argiolas A Melis M R Murgia S | 2000 | Brain Research Bulletin2000，51，5： | 1 |
| 16 | Dopamine and sexual behavior 显示文摘 | Melis MR Argiolas A | 1995 | Neurosci Biobehav Rev1995，19，1： | 1 |
| 17 | Late Electrical and Mechanical Remodeling After Atrial Septal Defect Closure in Children: Surgical Versus Percutaneous Approach显示文摘 | Biagio Castaldi Vladimiro L. Vida Anna Argiolas Nicola Maschietto Alessia Cerutti Dario Gregori Giovanni Stellin Ornella Milanesi | 2015 | The Annals of Thoracic Surgery2015，，1： | 1 |
| 18 | PD-168077, a selective dopamine D4 receptor agonist, induces penile erection when injected into the paraventricular nucleus of male rats 显示文摘 | ARGIOLAS A MELIS M R | 2005 | Neurosci Lett2005，379，1： | 1 |
| 19 | Oxytocin-induced penile erection and yawning: site of action in the })rain 显示文摘 | MELIS M R ARGIOLAS A GESSA G L | 1986 | Brain Res1986，398，2： | 1 |
| 20 | A polymorphism (K121Q) of human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance显示文摘 | Pizzuti A Frittitta L Argiolas A | 1999 | Diabetes1999，48，： | 1 |
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