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| 1 | Blood pressure management in acute stroke显示文摘Blood pressure(BP)is elevated in 75%or more of patients with acute stroke and is associated with poor outcomes.Whether to modulate BP in acute stroke has long been debated.With the loss of normal cerebral autoregulation,theoretical concerns are twofold:high BP can lead to cerebral oedema,haematoma expansion or haemorrhagic transformation;and low BP can lead to increased cerebral infarction or perihaematomal ischaemia.Published evidence from multiple large,high-quality,randomised trials is increasing our understanding of this challenging area,such that BP lowering is recommended in acute intracerebral haemorrhage and is safe in ischaemic stroke.Here we review the evidence for BP modulation in acute stroke,discuss the issues raised and look to on-going and future research to identify patient subgroups who are most likely to benefit. | Jason P Appleton Nikola Sprigg Philip M Bath | 2016 | Stroke & Vascular Neurology2016，1，2： | 7 |
| 2 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 3 | Relation of Transmitral Flow Velocity Patterns to Left Ventrieular Diastolic Function: New Insights from a Combined Hemodynamic and Doppler Eehocardiographie Study显示文摘 | Appleton C P Hatle L K Popp R L | 1988 | J Am Coil Cardiol1988，12，2： | 1 |
| 4 | Demonstration of Restrictive Ventricular Physiology by Doppler Eehocardiography显示文摘 | Appleton C P Hatle L K Popp R L | 1988 | J Am Coll Cardiol1988，11，4： | 1 |
| 5 | 显示文摘 | APPLETON J M H TYSON J F MOUNCE R P | 1986 | Anal Chim Acta1986，179，： | 1 |
| 6 | Open microscopy environment and findspots: in- tegrating image informatics with quantitative muhidimen- sional image analysis 显示文摘 | SCHIFFMANN D A DIKOVSKAYA D APPLETON P L | 2006 | BioTechniques2006，41，2： | 1 |
| 7 | Uncalcified ureteral stent in situ for 13 years 显示文摘 | Wood S J Tansley P D T Appleton D S | 1997 | J Urol1997，157，： | 1 |
| 8 | Forwardosmosis treatment of drilling mud and fracturing wastewater from oil and gas operations显示文摘 | Appleton E W Beaudry E G Xu P | 2013 | Desalination2013，，312： | 1 |
| 9 | Potential involvement of NOS and arginase in age-related behavioural impairments 显示文摘 | Liu P Smith PF Appleton I | 2004 | Exp Gerontol2004，39，8： | 1 |
| 10 | Age-related changes in nitric oxide synthase and arginase in the rat prefrontal cortex 显示文摘 | Liu P Smith PF Appleton I | 2004 | Neurobiol Aging2004，25，4： | 1 |
| 11 | Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures:a comparative simultaneous Doppler-catheterization study显示文摘 | OMMEN S R NISHIMURA R A APPLETON C P | 2000 | Circulation2000，102，15： | 1 |
| 12 | The Gender Wage Gap in Three African Countries显示文摘 | APPLETON S HODDINOOT J KRISHNAN P | 1999 | Economic Development and Cultural Change1999，47，2： | 1 |
| 13 | Kinetics and yields for the formation of coloured and aromatie thermal degradation products of annatto in foods显示文摘 | Michae J Scotter Laurence Castle Graeme P Appleton | 2001 | Food Chemistry2001，74，： | 1 |
| 14 | Fixation of fractures around unstable hip implants显示文摘 | Antoci V Appleton P Rodriguez EK | 2013 | Techniques in Orthopaedics2013，28，3： | 1 |
| 15 | Guidelines forcounselling in infertility:outline version显示文摘 | Boivin J Appleton T C Baetens P | | 0，，06： | 1 |
| 16 | Long-acting beta2-agonists for chronic obstructive pulmonary disease patients with poorly reversi- ble airflow limitation显示文摘 | Appleton S Poole P Smith B | 2002 | Cochrane Database Syst Rev2002，，01： | 1 |
| 17 | Recommen-dations for the evaluation of left ventricular diastolic functionby echocardiography 显示文摘 | Nagueh S F Appleton C P Gillebert T C | 2009 | Am Soc Echocardiogr2009，22，2： | 1 |
| 18 | Recommenda- tions for the evaluation of left ventricular diastolic funetion by e- chocardiography显示文摘 | Nagueh S F Appleton C P Gilleben T C | 2009 | Eur J Echocardiogr2009，10，2： | 1 |
| 19 | The rapid deter- ruination of chemical oxygen demand in waste waters and effluents by flow injection analysis 显示文摘 | Appleton J M H Tyson J F Moouce R P | 1986 | Anal Chim Acta1986，179，： | 1 |
| 20 | Nitric oxide synthase and arginase in the rat hippocampus and the entorhinal,perirhinal,postrhinal,and temporal cortices:regional variations and age-related changes显示文摘 | LIU P SMITH P F APPLETON I | 2003 | Hippocampus2003，13，7： | 1 |
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