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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Relation of Transmitral Flow Velocity Patterns to Left Ventrieular Diastolic Function: New Insights from a Combined Hemodynamic and Doppler Eehocardiographie Study显示文摘 | Appleton C P Hatle L K Popp R L | 1988 | J Am Coil Cardiol1988，12，2： | 1 |
| 3 | Febrile seizures:an update显示文摘 | Waiuiru C Appleton R | 2004 | Arch Dis Child2004，89，8： | 1 |
| 4 | Demonstration of Restrictive Ventricular Physiology by Doppler Eehocardiography显示文摘 | Appleton C P Hatle L K Popp R L | 1988 | J Am Coll Cardiol1988，11，4： | 1 |
| 5 | The manufacture, characterisation andmicrowave properties of aligned M ferrite fibres显示文摘 | PULLAR R C APPLETON S G BHATTACHARYA A K | 1998 | J Magn Magn Mater1998，186，： | 1 |
| 6 | Effects of upper platen configuration in the rotary forging process and rotary forging into a contoured lower platen 显示文摘 | APPLETON E SLATER R A C | 1973 | International Journal of Machine Tool Design and Research1973，13，1： | 1 |
| 7 | Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures:a comparative simultaneous Doppler-catheterization study显示文摘 | OMMEN S R NISHIMURA R A APPLETON C P | 2000 | Circulation2000，102，15： | 1 |
| 8 | Mercury contamination associated with artisanal gold mining on the island of Mindanao,the Philippines显示文摘 | APPLETON J D WILLIAMS T M BREWARD N APOSTOL A MIGUEL J MIRANDA C | 1999 | The Science of the Total Environment1999，228，： | 1 |
| 9 | Effect of seedling characteristics at plantingon browsing of Eucalyptus globulus by rabbits显示文摘 | McArthur C Appleton R | 2004 | Austrilian Forestry2004，67，1： | 1 |
| 10 | Canadian consensus recommendations for the measurement and reporting of diastolic dysfunction by echocardiography from the investigations of con sensus on diatolic dysfunction显示文摘 | Rakowski H Appleton C Chan KL | 1996 | J Am Soc Echocardiogr1996，9，5： | 1 |
| 11 | Guidelines forcounselling in infertility:outline version显示文摘 | Boivin J Appleton T C Baetens P | | 0，，06： | 1 |
| 12 | Recommen-dations for the evaluation of left ventricular diastolic functionby echocardiography 显示文摘 | Nagueh S F Appleton C P Gillebert T C | 2009 | Am Soc Echocardiogr2009，22，2： | 1 |
| 13 | Recommenda- tions for the evaluation of left ventricular diastolic funetion by e- chocardiography显示文摘 | Nagueh S F Appleton C P Gilleben T C | 2009 | Eur J Echocardiogr2009，10，2： | 1 |
| 14 | Febrile seizures: An update 显示文摘 | Waruiru C Appleton R | 2004 | Arch Dis Child2004，89，8： | 1 |
| 15 | Canadian consensus recommendation for the measurement and reporting of diastolic dysfunction by echocardiography: from the Investigators of Consensus on Diastolic Dysfunction by Echocardiography 显示文摘 | Rakowski H Appleton C Chan KL | 1996 | J Am Soc Echocardiogr1996，9，： | 1 |
| 16 | A preliminary parasitological analysis of fe-cal samples from a wild population of Costa Rican squirrel-monkeys(Saimiri oerstedi)显示文摘 | APPLETON C C BOINSKI S | 1991 | Journal of Medical Primatology1991，20，： | 1 |
| 17 | Trisodium citrate 4% : an alternative to heparin capping of haemodialysis catheters 显示文摘 | Lok C E Appleton D Bhola C | 2007 | Nephrol Dial Transplant2007，22，2： | 1 |
| 18 | Independent association of HbA( 1 c)and incident cardiovascular disease in people without diabetes 显示文摘 | ADAMS R J APPLETON S L HILL C L | 2009 | Obesity2009，17，3： | 1 |
| 19 | The manufacture, characterization and microwave properties of aligned M ferrite fibres显示文摘 | Pullar R C Appleton S G Bhattacharya A K | 1998 | J Magn Magn Mater1998，186，： | 1 |
| 20 | Recommendations for the evaluation of left ventricular diastolicfunction by echocardiography 显示文摘 | NAGUEH S F APPLETON C P GILLEBEHT T C | 2009 | J Am Soc Echocardiogr2009，22，2： | 1 |
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