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| 1 | 北京居民对2008奥运会影响的态度和看法显示文摘通过对1165名北京居民的电话调查分析其对2008奥运会影响的态度和看法,本文验证发展出4个方面的(社会心理、社会生活、城市发展、经济发展)20条具体盛事影响的条目。另外,依照对奥运影响的看法,居民被分为两个组群:积极派和中间派。一些影响居民组群归属的固定变量得以确认。调查结果建议在奥运规划准备过程中更多了解当地居民的意见将有助于取得奥运会的全面成功。 | 周勇 John Ap | 2008 | 旅游学刊2008，23，7： | 27 |
| 2 | Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer显示文摘Early screening for colorectal cancer(CRC) holds the key to combat and control the increasing global burden of CRC morbidity and mortality. However, the current available screening modalities are severely inadequate because of their high cost and cumbersome preparatory procedures that ultimately lead to a low participation rate. People simply do not like to have colonoscopies. It would be ideal, therefore, to develop an alternative modality based on blood biomarkers as the first line screening test. This will allow for the differentiation of the general population from high risk individuals. Colonoscopy would then become the secondary test, to further screen the high risk segment of the population. This will encourage participation and therefore help to reach the goal of early detection and thereby reduce the anticipated increasing global CRC incidence rate. A blood-based screening test is anappealing alternative as it is non-invasive and poses minimal risk to patients. It is easy to perform, can be repeated at shorter intervals, and therefore would likely lead to a much higher participation rate. This review surveys various blood-based test strategies currently under investigation, discusses the potency of what is available, and assesses how new technology may contribute to future test design. | Ganepola AP Ganepola Joel Nizin John R Rutledge David H Chang | 2014 | World Journal of Gastrointestinal Oncology2014，6，4： | 11 |
| 3 | Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer显示文摘AIM:To develop a panel of blood-based diagnostic biomarkers consisting of circulating microRNAs for the detection of pancreatic cancer at an early stage.METHODS:Blood-based circulating microRNAs were profiled by high throughput screening using microarray analysis,comparing differential expression between early stage pancreatic cancer patients(n = 8) and healthy controls(n = 11).A panel of candidate microRNAs was generated based on the microarray signature profiling,including unsupervised clustering and statistical analysis of differential expression levels,and findings from the published literature.The selected candidate microRNAs were then confirmed using TaqMan real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR) to further narrow down to a three-microRNA diagnostic panel.The three-microRNA diagnostic panel was validated with independent experimental proce-dures and instrumentation of RT-qPCR at an independent venue with a new cohort of cancer patients(n = 11),healthy controls(n = 11),and a group of high risk controls(n = 11).Receiver operating characteristic curve analysis was performed to assess the diagnostic capability of the three-microRNA panel.RESULTS:In the initial high throughput screening,1220 known human microRNAs were screened for differential expression in pancreatic cancer patients versus controls.A subset of 42 microRNAs was then generated based on this data analysis and current published literature.Eight microRNAs were selected from the list of 42 targets for confirmation study,and three-microRNAs,miR-642b,miR-885-5p,and miR-22,were confirmed to show consistent expression between microarray and RT-qPCR.These three microRNAs were then validated and evaluated as a diagnostic panel with a new cohort of patients and controls and found to yield high sensitivity(91%) and specificity(91%) with an area under the curve of 0.97(P < 0.001).Compared to the CA19-9 marker at 73%,the three-microRNA panel has higher sensitivity although CA19-9 has higher specificity of 100%.CONCLUSION:The identified panel of three microRNA biomarkers can potentially be used as a diagnostic tool for early stage pancreatic cancer. | Ganepola AP Ganepola John R Rutledge Paritosh Suman Anusak Yiengpruksawan David H Chang | 2014 | World Journal of Gastrointestinal Oncology2014，6，1： | 9 |
| 4 | Residenta'Perceptious on Tourism Impacts显示文摘 | | 1992 | Annals of Tourism Research1992，，19： | 1 |
| 5 | John L Crompton Developing and Testing a Tourism Impact Scale显示文摘 | John AP | | 0，，02： | 1 |
| 6 | Abnormal signal overaged electrocardiogram(ASECG) in obesity 显示文摘 | Lalani AP kanna B John J | 2000 | Obese Res2000，8，： | 1 |
| 7 | Impact of chronic lead exposure on selected biological markers显示文摘 | Jangid AP John PJ Yadav D | 2012 | Indian J Clin Biochem2012，27，1： | 1 |
| 8 | Residents' perceptions on tourism impacts显示文摘 | John Ap | 1992 | Annals of Tourism Research1992，19，4： | 1 |
| 9 | Residents' Research on the Social Impacts of Tourism 显示文摘 | John Ap | 1990 | Annals of Tourism Research1990，17，4： | 1 |
| 10 | Developing and Testing a Tourism Impact Scale显示文摘 | John Ap Crompton J L | 1998 | Journal of Travel Research1998，37，2： | 1 |
| 11 | A sensitive non-radioactive northern blot method to detect small RNAs显示文摘 | Kim SW Li Z Moore PS Monaghan AP Chang Y Nichols M John B | | 0，，07： | 1 |
| 12 | An Analysis of Tourism Policy Development in Modern China显示文摘 | Chong King Ap John | 1999 | Tourism Management1999，20，4： | 1 |
| 13 | Prevalence of metabolic syn- drome among Australians with severe mental illness 显示文摘 | John AP Koloth R Dragovic M | 2009 | Med J Aust2009，190，4： | 1 |
| 14 | 'Cooperation under Tourism : Trends, Development, and Marketing' 1997 Annual APTA Conference 显示文摘 | John Ap | 1997 | Asia Pacific Journal of Tourism Research1997，2，1： | 1 |
| 15 | IQ-Motif proteins influence intracellular free Ca^2+ in hippocampal neurons through their interactions with ealmodulin显示文摘 | Yoshihisa K John AP Harel ZS | 2008 | J Neurophysiol2008，99，1： | 1 |
| 16 | Xanthine oxidase inhibition ameliorates cardiovascular dysfunction in dogs with pacing-induced heart failure显示文摘 | Amado LC Saliaris AP Raju SV Lehrke S St John M Xie J | 2005 | J Mol Cell Cardiol2005，39，： | 1 |
| 17 | Neurogranin controls the spatiotemporal pattern of postsynaptic Ca^2+ /CaM signaling显示文摘 | Yoshihisa K John AP Waxhammn MN | 2007 | Biophys J2007，93，11： | 1 |
| 18 | Case study on tour guiding:professionalism, issues and problems 显示文摘 | Ap John Wong Kevin K F | 2001 | Tourism Management2001，，5： | 1 |
| 19 | How companies can preserve market dominance afterpatents expire显示文摘 | JOHN AP | 2006 | Long Range Planning2006，，39： | 1 |
| 20 | Case study on tour guiding: professional- ism, issues and problems 显示文摘 | John Ap Kevin K F Wong | 2001 | Tourism Management2001，22，5： | 1 |
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