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| 1 | Inflammation, oxidative stress and renin angiotensin system in atherosclerosis显示文摘Atherosclerosis is a chronic inflammatory disease associated with cardiovascular dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke and peripheral thromboses. It has been predicted that atherosclerosis will be the primary cause of death in the world by 2020. Atherogenesis is initiated by endothelial injury due to oxidative stress associated with cardiovascular risk factors including diabetes mellitus, hypertension, cigarette smoking, dyslipidemia, obesity, and metabolic syndrome. The impairment of the endothelium associated with cardiovascular risk factors creates an imbalance between vasodilating and vasoconstricting factors, in particular, an increase in angiotensin Ⅱ(Ang Ⅱ) and a decrease in nitric oxide. The renin-angiotensin system(RAS), and its primary mediator Ang Ⅱ, also have a direct influence on the progression of the atherosclerotic process via effects on endothelial function, inflammation, fibrinolytic balance, and plaque stability. Anti-inflammatory agents [statins, secretory phospholipase A2 inhibitor, lipoprotein-associated phospholipase A2 inhibitor, 5-lipoxygenase activating protein, chemokine motif ligand-2, C-C chemokine motif receptor 2 pathway inhibitors, methotrexate, IL-1 pathway inhibitor and RAS inhibitors(angiotensin-converting enzyme inhibitors)], Ang Ⅱ receptor blockers and ranin inhibitors may slow inflammatory processes and disease progression. Several studies in human using anti-inflammatory agents and RAS inhibitors revealed vascular benefits and reduced progression of coronary atherosclerosis in patients with stable angina pectoris; decreased vascular inflammatory markers, improved common carotid intima-media thickness and plaque volume in patients with diagnosed atherosclerosis. Recent preclinical studies have demonstrated therapeutic efficacy of vitamin D analogs paricalcitol in Apo E-deficient atherosclerotic mice. | Kazim Husain Wilfredo Hernandez Rais A Ansari Leon Ferder | 2015 | World Journal of Biological Chemistry2015，6，3： | 84 |
| 2 | Radiofrequency ablation or percutaneous ethanol injection for the treatment of liver tumors显示文摘The liver is a common location of both primary and secondary malignancies. For unresectable liver cancer, many local ablative therapies have been developed. These include e.g., percutaneous ethanol injection (PEI), percutaneous acetic acid injection, radiofrequency ablation (RFA), cryoablation, microwave ablation, laserinduced thermotherapy, and high-intensity focused ultrasound. RFA has recently gained interest and is the most widely applied thermoablative technique. RFA allows more effective tumor control in fewer treatment sessions compared with PEI, but with a higher rate of complications. However, there are certain circumstances where PEI therapy represents a better strategy to control liver tumors than RFA, especially in situations where RFA is difficult, for example when large vessels surround the tumor. In the context of hepatocellular carcinoma (HCC), both RFA and PEI are feasible and of benefit in non-operable patients. RFA seems superior to PEI in HCC > 2 cm, and the combination of interventions may be of benefit in selected patients. Liver resection is superior to RFA for patients with HCC meeting the Milan criteria, but RFA can be employed in tumors ≤ 3 cm and where there is an increased expected operative mortality. In addition, some lines of evidence indicate that RFA and PEI can be employed as a bridge to liver transplantation. The use of RFA in colorectal liver metastases is currently limited to unresectable disease and for patients unfit for surgery. The aim of this article is to summarize the current status of RFA in the management of liver tumors and compare it to the cheap and readily available technique of PEI. | Daniel Ansari Roland Andersson | 2012 | World Journal of Gastroenterology2012，18，10： | 39 |
| 3 | Tissue factor in predicted severe acute pancreatitis显示文摘AIM: To study tissue factor (TF) in acute pancreatitis and evaluate the role of TF as a predictive marker of severity. METHODS: Forty-nine consecutive patients admitted to Lund University Hospital, fulfilling the criteria of predicted severe acute pancreatitis (AP), were recruited prospectively between 2002 and 2004. Blood samples for TF analyses were drawn at inclusion in the study and 12 h, 1 d and 3 d later. RESULTS: Twenty-seven patients developed mild AP, and 22 patients severe AP. At inclusion in the study, the groups were comparable with respect to gender, aetiology, Acute Physiology and Chronic Health Evaluation Ⅱ score, and duration of pain. At inclusion in the study and at 12 h, TF was higher in the severe AP group (P = 0.035 and P = 0.049, respectively). After 1 and 3 d, no differences in TF levels were noted. Interleukin (IL)-6 was significantly higher in the severe AP group at all of the studied time points. C-reactive protein (CRP) was significantly higher in the AP group at 1 and 3 d. In receiver operating characteristic-curves, the area under the curve (AUC) for TF was 0.679 (P = 0.035) at inclusion in the study, and a cut off level for TF of 40 pg/mL showed a sensitivity of 71% and a specificity of 67%, whereas corresponding AUC for IL-6 was 0.775, P = 0.001, and for CRP was 0.653. IL-6 showed better AUC-values than TF at all time points studied. CONCLUSION: TF-levels are raised early in severe AP. TF as an early predictive marker of severe AP is superior to CRP, but inferior to IL-6. | Ellen Andersson Jakob Axelsson Gunilla Eckerwall Daniel Ansari Roland Andersson | 2010 | World Journal of Gastroenterology2010，16，48： | 26 |
| 4 | Update on the management of pancreatic cancer:Surgery is not enough显示文摘Pancreatic ductal adenocarcinoma(PDAC) represents the fourth cause of death in cancer and has a 5-year survival of < 5%.Only about 15% of the patients present with a resectable PDAC with potential to undergo 'curative' surgery.After surgery,local and systemic recurrence,is though very common.The median survival of resected patients with adjuvant chemotherapy after surgery is only 20-23 mo.This underscores the significant need to improve PDAC management strategies.Increased survival rate is dependent on new breakthroughs in our understanding of not at least tumor biology.The aim of this review is to update and comment on recent knowledge concerning PDAC biology and new diagnostics and treatment modalities.One fundamental approach to improve survival rates is by earlier and improved diagnosis of the disease.In recent years,novel blood-based biomarkers have emerged based on genetic,epigenetic and protein changes in PDAC with very promising results.For biomarkers to enter clinical practice they need to have been developed using adequate control groups and provide high sensitivity and specificity and by this identify patients at risk already in a pre-symptomatic stage.Another way to improve outcomes,is by employing neoadjuvant treatments thereby increasing the number of resectable cases.Novel systemic treatment regimes like FOLFIRINOX and nab-paclitaxel have demonstrated improvements in prolonging survival in advanced cases,but long-term survival is still scarce.The future improved understanding of PDAC biology will inevitably render new treatment options directed against both the cancer cells and the surrounding microenvironment. | Daniel Ansari Adam Gustafsson Roland Andersson | 2015 | World Journal of Gastroenterology2015，21，11： | 18 |
| 5 | Does gemcitabine-based combination therapy improve the prognosis of unresectable pancreatic cancer?显示文摘AIM:To assess whether gemcitabine-based combination therapy improves the prognosis of unresectable pancreatic cancer compared with gemcitabine treatment alone.METHODS:A quantitative up-to-date meta-analysis was undertaken to investigate the efficacy of gemcitabine-based combination treatment compared with gemcitabine monotherapy in locally advanced or metastatic pancreatic cancer.Inclusion was limited to highquality randomized clinical trials.RESULTS:Twenty-six studies were included in the present analysis,with a total of 8808 patients recruited.The studies were divided into four subgroups based on the different kinds of cytotoxic agents,including platinum,fluoropyrimidine,camptothecin and targeted agents.Patients treated with gemcitabine monotherapy had significantly lower objective response rate [risk ratio(RR),0.72;95% confidence interval(CI):0.63-0.83;P < 0.001],and lower 1-year overall survival(RR,0.90;95%CI:0.82-0.99;P = 0.04).Gemcitabine monotherapy caused fewer complications,including fewer grade 3-4 toxicities:including vomiting(RR,0.75;95%CI:0.62-0.89;P = 0.001),diarrhea(RR,0.66;95%CI:0.49-0.89;P = 0.006),neutropenia(RR,0.88;95%CI:0.72-1.06;P = 0.18),anemia(RR,0.96;95%CI:0.82-1.12;P = 0.60),and thrombocytopenia(RR,0.76;95%CI:0.60-0.97;P = 0.03) compared with gemcitabine combination therapies.CONCLUSION:Gemcitabine combination therapy provides a modest improvement of survival,but is associated with more toxicity compared with gemcitabine monotherapy. | Chen Sun Daniel Ansari Roland Andersson De-Quan Wu | 2012 | World Journal of Gastroenterology2012，18，35： | 15 |
| 6 | All-optical forward-viewing photoacoustic probe for high-resolution 3D endoscopy显示文摘A miniature forward-viewing endoscopic probe that provides high-resolution 3D photoacoustic images is demonstrated.The probe is of outer diameter 3.2mm and comprised of a transparent Fabry-Pérot(FP)polymer-film ultrasound sensor that is located at the distal end of a rigid optical fiber bundle.Excitation laser pulses are coupled simultaneously into all cores of the bundle and are transmitted through the FP sensor to provide wide-field tissue illumination at the distal end.The resulting photoacoustic waves are mapped in 2D by sequentially scanning the input end of the bundle with an interrogation laser beam in order to individually address different points on the FP sensor.In this way,the sensor acts as a high-density ultrasound array that is comprised of 50,000 individual elements,each of which is 12μm in diameter,within the 3.2mm diameter footprint of the probe.The fine spatial sampling that this affords,along with the wide bandwidth(f_(-3dB)=34 MHz)of the sensor,enables a high-resolution photoacoustic image to be reconstructed.The measured on-axis lateral resolution of the probe was depth-dependent and ranged from 45-170μm for depths between 1 and 7 mm,and the vertical resolution was 31μm over the same depth range.The system was evaluated by acquiring 3D images of absorbing phantoms and the microvascular anatomies of a duck embryo and mouse skin.Excellent image fidelity was demonstrated.It is anticipated that this type of probe could find application as a tool for guiding laparoscopic procedures,fetal surgery and other minimally invasive interventions that require a millimeter-scale forward-viewing 3D photoacoustic imaging probe. | Rehman Ansari Edward Z.Zhang Adrien E.Desjardins Paul C.Beard | 2018 | Light(Science & Applications)2018，7，1： | 11 |
| 7 | Role of magnetic resonance imaging in the detection and characterization of solid pancreatic nodules: An update显示文摘Pancreatic ductal adenocarcinoma is the most common malignant tumor of the pancreas. The remaining pancreatic tumors are a diverse group of pancreatic neoplasms that comprises cystic pancreatic neoplasms, endocrine tumors and other uncommon pancreatic tumors. Due to the excellent soft tissue contrast resolution, magnetic resonance imaging(MRI) is frequently able to readily separate cystic from noncystic tumors. Cystic tumors are often easy to diagnose with MRI; however, noncystic non-adenocarcinoma tumors may show a wide spectrum of imaging features, which can potentially mimic ductal adenocarcinoma. MRI is a reliable technique for the characterization of pancreatic lesions. The implementation of novel motionresistant pulse sequences and respiratory gating techniques, as well as the recognized benefits of MR cholangiopancreatography, make MRI a very accurate examination for the evaluation of pancreatic masses. MRI has the distinctive ability of non-invasive assessment of the pancreatic ducts, pancreatic parenchyma, neighbouring soft tissues, and vascular network in one examination. MRI can identify different characteristics of various solid pancreatic lesions, potentially allowing the differentiation of adenocarcinoma from other benign and malignant entities. In this review we describe the MRI protocols and MRI characteristics of various solid pancreatic lesions. Recognition of these characteristics may establish the right diagnosis or at least narrow the differential diagnosis, thus avoiding unnecessary tests or procedures and permitting better management. | Najwa Al Ansari Miguel Ramalho Richard C Semelka Valeria Buonocore Silvia Gigli Francesca Maccioni | 2015 | World Journal of Radiology2015，7，11： | 9 |
| 8 | Alcohol-induced hypertension: Mechanism and prevention显示文摘Epidemiological, preclinical and clinical studies es-tablished the association between high alcohol con-sumption and hypertension. However the mechanism through which alcohol raises blood pressure remains elusive. Several possible mechanisms have been pro-posed such as an imbalance of the central nervous system, impairment of the baroreceptors, enhanced sympathetic activity, stimulation of the renin-angio-tensin-aldosterone system, increased cortisol levels, increased vascular reactivity due to increase in intracel-lular calcium levels, stimulation of the endothelium to release vasoconstrictors and loss of relaxation due to inflammation and oxidative injury of the endothelium leading to inhibition of endothelium-dependent nitric oxide production. Loss of relaxation due to inflamma-tion and oxidative injury of the endothelium by angio-tensin II leading to inhibition of endothelium-dependent nitric oxide production is the major contributors of the alcohol-induced hypertension. For the prevention of alcohol-induced hypertension is to reduce the amount of alcohol intake. Physical conditioning/exercise trainingis one of the most important strategies to prevent/treat chronic alcohol-induced hypertension on physiological basis. The efficacious pharmacologic treatment includes the angiotensin-converting enzyme(ACE) inhibitors or angiotensin Ⅱ type 1 receptor blockers(ARBs) which have antioxidant activity and calcium channel blockers. The most effective prevention and treatment of alcohol-induced hypertension is physical exercise and the use of ACE inhibitors or ARBs in the | Kazim Husain Rais A Ansari Leon Ferder | 2014 | World Journal of Cardiology2014，6，5： | 8 |
| 9 | Intra-familial prevalence of hepatitis B virologic markers in HBsAg positive family members in Nahavand, Iran显示文摘AIM: To determine the prevalence of hepatitis B in Nahavand and evaluate the HBsAg positive prevalence in families with a member who was confirmed to have HBV infection.METHODS: This study was performed in two phases. In the first phase, 1 824 subjects in Nahavand city were selected. The interviewers visited the houses of chosen families to fill the questionnaire and take the blood samples.All subjects signed an informed consent before interviews and blood sampling. The samples were evaluated for HBV virologic markers. In the second phase, 115 HBsAg-positive cases were enrolled and evaluated for HBV virologic markers.RESULTS: The prevalence of positive HBsAg in Nahavand was 2.3%. The most frequent relatives of index cases were sons and daughters (32.2% and 23.5% respectively).Twelve (11%) of all family members were HBsAg positive.Fifty (56.2%) were isolated HBsAb positive and only one person (2.5%) was isolated HBcAb positive. The higher rates of HBsAg marker were detected in the brothers (1-25%) and fathers (1-12.5%). The infection rate in husbands and wives of index cases was 10%. Only two (16.7%) of all HBsAg-positive participants reported previous HBV vaccination.CONCLUSION: The prevalence of intra-familial HBV infection is lower in Nahavand of Iran compared to other studies.More attention should be paid to HBV vaccination and risk-lowering activities. | Amir Houshang Mohammad Alizadeh Mitra Ranjbar Shahin Ansari Seyed Moayed Alavian Hamid Mohaghegh Shalmani Leila Hekmat Mohammad Reza Zali | 2005 | World Journal of Gastroenterology2005，11，31： | 8 |
| 10 | Helicobacter pylori Bab A in adaptation for gastric colonization显示文摘Helicobacter pylori(H. pylori) as a causative agent of gastric complications, is well adapted for the colonization of gastric mucosa. Although the infectious process depends on several factors, the adhesion to the gastric mucosa is the first and important step. Among several outer membrane proteins, Bab A is one of the significant protein involving in many inflammatory processes in addition to its role in the attachment for the persistent colonization. We performed a Pub Med search using the key words: 'bab A ', 'pylori', 'gastric complications', 'homologous recombination', 'slipped strand mispairing'; a total of 249 articles were displayed. Of these we mainly focused on articles with the full text in English and published between 2005 and 2016. H. pylori Bab A is involved in binding with receptors; however, its synthesis is regulated by phase variation. In this review we confirm that H. pylori bab A can be modulated at the molecular and functional levels to adapt to the stress within the gastro-intestinal tract. | Shamshul Ansari Yoshio Yamaoka | 2017 | World Journal of Gastroenterology2017，23，23： | 8 |
| 11 | hENT1 expression is predictive of gemcitabine outcome in pancreatic cancer: A systematic review显示文摘High human equilibrative nucleoside transporter 1(hENT1)-expression has shown a survival benefit in pancreatic cancer patients treated with gemcitabine in several studies.The aim of this systematic review was to summarize the results and try to assess the predictive value of hENT1 for determining gemcitabine outcome in pancreatic cancer.Relevant articles were obtained from PubMed,Embase and Cochrane databases.Studies evaluating hENT1-expression in pancreatic tumor cells from patients treated with gemcitabine were selected.Outcome measures were overall survival,disease-free survival(DFS),toxicity and response rate.The database searches identified 10 studies that met the eligibility criteria,and a total of 855 patients were included.Nine of 10 studies showed a statistically significant longer overall survival in univariate analyses in patients with high hENT1-expression compared to those with low expression.In the 7 studies that reported DFS as an outcome measure,6 had statistically longer DFS in the high hENT1 groups.Both toxicity and response rate were reported in only 2 articles and it was therefore hard to draw any major conclusions.This review provides evidence that hENT1 is a predictive marker for pancreatic cancer patients treated with gemcitabine.Some limitations of the review have to be taken into consideration,the majority of the included studies had a retrospective design,and there was no standardized scoring protocol for hENT1-expression. | Stina Nordh Daniel Ansari Roland Andersson | 2014 | World Journal of Gastroenterology2014，20，26： | 7 |
| 12 | Re-evaluation of classical prognostic factors in resectable ductal adenocarcinoma of the pancreas显示文摘Pancreatic ductal adenocarcinoma carries a poor prognosis with annual deaths almost matching the reported incidence rates. Surgical resection offers the only potential cure. Yet, even among patients that undergo tumor resection, recurrence rates are high and long-term survival is scarce. Various tumorrelated factors have been identified as predictors of survival after potentially curative resection. These factors include tumor size, lymph node disease, tumor grade, vascular invasion, perineural invasion and surgical resection margin. This article will re-evaluate the importance of these factors based on recent publications on the topic, with potential implications for treatment and outcome in patients with pancreatic cancer. | Daniel Akerberg Daniel Ansari Roland Andersson | 2016 | World Journal of Gastroenterology2016，22，28： | 7 |
| 13 | 用埋入式光纤传感器探测建筑结构中的声发射(英文)显示文摘声发射技术已经应用于金属和混凝土结构中 ,作为探测内部裂缝的一种无损检测方法。目前用的技术都是由压电换能器来采集声发射信号。讨论了基于用光纤技术的声发射传感器的开发和测量方法。它是用埋入式光纤传感器来监测类似桥梁、高速公路、隧道和房屋建筑等混凝土结构中的开裂信号。 | 陈仲裕 Farhad Ansari | 2000 | 光学学报2000，20，8： | 6 |
| 14 | Potential use of durian fruit(Durio zibenthinus Linn) as an adjunct to treat infertility in polycystic ovarian syndrome显示文摘Infertility due to polycystic ovarian syndrome(PCOS)is a worldwide problem that is increasing at alarming rates.Insulin resistance,the prime factor of PCOS,induces comorbid metabolic syndrome as well.Durian(Durio zibenthinus Linn),a fruit of Southeast Asia,is used as a natural supplement in healthy diets.This paper is a short literature review that examines the fruit's effects against various components of metabolic syndrome and its fertility-enhancing properties in PCOS.Various published literature was reviewed to learn of the anti-infl ammatory,anti-oxidant,anti-obesity,anticholesterol,and antihypoglycaemic nature of the fruit.The literature search was done using PubM ed,Google Scholar and library databases.The keywords used were polycystic ovarian syndrome,infertility,metabolic syndrome and Durian zibenthinus Linn.Reviewed studies showed that the fruit is effective against various components of metabolic syndrome,but the mechanisms of action against anovulation and menstrual disturbances in PCOS have yet to be studied.The traditional use of durian as a fertility-enhancing agent needs to be validated scientifi cally by isolating its various components and ascertaining its fertility enhancing properties. | Reshma M. Ansari | 2016 | Journal of Integrative Medicine2016，14，1： | 6 |
| 15 | Influence of friction stir processing conditions on corrosion behavior of AZ31B magnesium alloy显示文摘The present study aims to investigate the effect of friction stir processing(FSP)conditions on the corrosion characteristic of AZ31B magnesium alloy.Specimens made of AZ31B alloy were friction stir processed under various processing conditions,and their microstructure and corrosion behavior were studied.The corrosion behavior was studied by potentiodynamic polarization,electrochemical impedance spectroscopy(EIS),and immersion test in 3.5%sodium chloride(NaCl)solution.The results showed a substantial improvement in the corrosion resistance of the friction stir processed AZ31B alloy.The improvement is likely a result of more stable corrosion products and microstructure refinement formed after friction sir processing. | Hamed Seifiyan Mahmoud Heydarzadeh Sohi Mohammad Ansari Donya Ahmadkhaniha Mohsen Saremi | 2019 | Journal of Magnesium and Alloys2019，7，4： | 6 |
| 16 | Esophageal tissue engineering:A new approach for esophageal replacement显示文摘A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed. | Giorgia Totonelli Panagiotis Maghsoudlou Jonathan M Fishman Giuseppe Orlando Tahera Ansari Paul Sibbons Martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi | 2012 | World Journal of Gastroenterology2012，18，47： | 5 |
| 17 | Multiplex qPCR for serodetection and serotyping of hepatitis viruses: A brief review显示文摘The present review describes the current status of multiplex quantitative real time polymerase chain reaction(q PCR) assays developed and used globally for detection and subtyping of hepatitis viruses in body fluids. Several studies have reported the use of multiplex q PCR for the detection of hepatitis viruses, including hepatitis A virus(HAV), hepatitis B virus(HBV), hepatitis C virus(HCV), hepatitis D virus(HDV), and hepatitis E virus(HEV). In addition, multiplex q PCR has also been developed for genotyping HBV, HCV, and HEV subtypes. Although a single step multiplex q PCR assay for all six hepatitis viruses, i.e., A to G viruses, is not yet reported, it may be available in the near future as the technologies continue to advance. All studies use a conserved region of the viral genome as the basis of amplification and hydrolysis probes as the preferred chemistries for improved detection. Based on a standard plot prepared using varying concentrations of template and the observed threshold cycle value, it is possible to determine the linear dynamic range and to calculate an exact copy number of virus in the specimen. Advantages of multiplex q PCR assay over singleplex or other molecular techniques in samples from patients with co-infection include fast results, low cost, and a single step investigation process. | Mohammad Irshad Priyanka Gupta Dhananjay Singh Mankotia Mohammad Ahmad Ansari | 2016 | World Journal of Gastroenterology2016，22，20： | 5 |
| 18 | INTERMOLECULAR INTERACTION OF A NEUTRAL POLYMERIC BONDING AGENT CONTAINING N-VINYLPYRROLIDONE UNITS WITH AMMONIUM PERCHLORATE AND KETO-RDX显示文摘The interaction of a new neutral polymeric bonding agent(NPBA) containing N-Vinylpyrrolidone units with two types of oxidizers(ammonium perchlorate and Keto-RDX) was investigated by X-ray photoelectron spectroscopy(XPS) and Fourier transform infrared spectroscopy(FTIR). NPBA forms a layer of film on the surface of oxidizers. The paper gives hypothetical mechanisms for improving significantly mechanical properties by addition of the neutral polymeric bonding agent(NPBA). | Forouzan Gholamian Mahdi Ansari Mohammad Abdullah Farideh Bataghva Sara Ghariban-Lavasani | 2013 | Chinese Journal of Polymer Science2013，31，10： | 4 |
| 19 | Pancreatic cancer:Translational research aspects and clinical implications显示文摘Despite improvements in surgical techniques and adjuvant chemotherapy,the overall mortality rates in pancreatic cancer have generally remained relatively unchanged and the 5-year survival rate is actually below 2%.This paper will address the importance of achieving an early diagnosis and identifying markers for prognosis and response to therapy such as genes,proteins,microRNAs or epigenetic modifications.However,there are still major hurdles when translating investigational biomarkers into routine clinical practice.Furthermore,novel ways of secondary screening in high-risk individuals,such as artificial neural networks and modern imaging,will be discussed.Drug resistance is ubiquitous in pancreatic cancer.Several mechanisms of drug resistance have already been revealed,including human equilibrative nucleoside transporter-1 status,multidrug resistance proteins,aberrant signaling pathways,microRNAs,stromal influence,epithelial-mesenchymal transition-type cells and recently the presence of cancer stem cells/cancer-initiating cells.These factors must be considered when developing more customized types of intervention('personalized medicine').In the future,multifunctional nanoparticles that combine a specific targeting agent,an imaging probe,a cell-penetrating agent,a biocompatible polymer and an anticancer drug may become valuable for the management of patients with pancreatic cancer. | Daniel Ansari Bi-Cheng Chen Lei Dong Meng-Tao Zhou Roland Andersson | 2012 | World Journal of Gastroenterology2012，18，13： | 4 |
| 20 | A controllable hydrothermal method to prepare La(OH)_3 nanorods using new precursors显示文摘Using the hydrothermal method, lanthanum hydroxide nanorods were synthesized by the reaction of La Cl3·7H2O, ethylenediamine, and hydrazine. According to SEM results, ethylenediamine and hydrazine with p H management could control the particle growth and played an important role in formation of lanthanum hydroxide nanorods. The morphology and microstructure of the obtained products were characterized by X-ray diffraction(XRD) spectra, energy-dispersive X-ray spectroscopy(EDX), Fourier transformed infrared(FTIR) spectrum, transmission electron microscopy(TEM), and scanning electron microscopy(SEM). Furthermore, the effects of the molar ratio of the precursors as well as the reaction temperature and time on the morphology and particle size of the products were investigated. | Mehdi Mousavi-Kamazani Sakineh Alizadeh Fateme Ansari Masoud Salavati-Niasari | 2015 | Journal of Rare Earths2015，33，4： | 4 |
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