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1篇 您的检索式:作者名="Anna Varlamicheva"
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1NS3 protease inhibitors for treatment of chronic hepatitis C: Efficacy and safety显示文摘A new treatment paradigm for hepatitis C is that the treatment must include an existing direct-acting antiviral agent, namely, a protease inhibitor(PI) combined with PEGylated interferon-a and ribavirin. The currently mar-keted PIs and PIs in clinical trials have different mecha-nisms of action. The development of new PIs aims for an improved safety profile and higher effectiveness. This article reviews NS3/4A protease inhibitors, focusing on major criteria such as their effectiveness and safety. Specific attention is paid to dosing regimens and adverse event profiles of PIs administered in clinical settings.Igor Bakulin Victor Pasechnikov Anna Varlamicheva Irina Sannikova 2014World Journal of Hepatology2014,6,5:2
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