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您的检索式：作者名="Anja Scheller"
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| 1 | Oligodendroglial GABAergic Signaling:More Than Inhibition!显示文摘GABA is the main inhibitory neurotransmitter in the CNS acting at two distinct types of receptor:ligand-gated ionotropic GABAA receptors and G protein-coupled metabotropic GABAB receptors,thus mediating fast and slow inhibition of excitability at central synapses.GABAergic signal transmission has been intensively studied in neurons in contrast to oligodendrocytes and their precursors(OPCs),although the latter express both types of GABA receptor.Recent studies focusing on interneuron myelination and interneuron-OPC synapses have shed light on the importance of GABA signaling in the oligodendrocyte lineage.In this review,we start with a short summary on GABA itself and neuronal GABAergic signaling.Then,we elaborate on the physiological role of GABA receptors within the oligodendrocyte lineage and conclude with a description of these receptors as putative targets in treatments of CNS diseases. | Xianshu Bai Frank Kirchhoff Anja Scheller | 2021 | Neuroscience Bulletin2021，37，7： | 4 |
| 2 | Progenies of NG2 glia: what do we learn from transgenic mouse models ?显示文摘In the mammalian central nervous system,nerve-glia antigen 2(NG2)glia are considered the fourth glial population in addition to astrocytes,oligodendrocytes and microglia.The fate of NG2 glia in vivo has been carefully studied in several transgenic mouse models using the Cre/loxP strategy.There is a clear agreement that NG2 glia mainly serve as progenitors for oligodendrocytes and a subpopulation of astrocytes mainly in the ventral forebrain,whereas the existence of a neurogenic potential of NG2 glia is lack of adequate evidence.This mini review summarizes the findings from recent studies regarding the fate of NG2 glia during development.We will highlight the age-and-region-dependent heterogeneity of the NG2 glia differentiation potential.We will also discuss putative reasons for inconsistent findings in various transgenic mouse lines of previous studies. | Qilin Guo Anja Scheller Wenhui Huang | 2021 | Neural Regeneration Research2021，16，1： | 1 |
| 3 | Pathology-induced NG2 proteoglycan expression in microglia显示文摘Oligodendrocyte precursor cells(OPCs)and microglia are two very fascinating cell types with a multitude of important but different functions.At a first glance,they appear not to share many cellular properties,nor are directly related to one another or derived from a common ancestor.Despite all differences,emerging data show that both cell types express the protein nerve/glial antigen 2(NG2)after pathological insults(Figure 1).For years,it remained controversial whether microglia really could express NG2 upon injury,with contradictory results reported among different disease models.Addressing this question,we could recently show by using triple transgenic knock-in mice and either an acute injury model(stab wound injury)or the middle cerebral artery occlusion combined with immunohistochemistry that a subset of microglia activates the cspg4 gene in a disease dependent manner leading to a bonafide microglia-specific NG2 protein expression besides OPCs and pericytes.Our data show that the cspg4 gene not only gets transcribed in microglia based on reporter expression after recombination,but also the protein itself is expressed(Huang et al.,2020). | Erika Meyer Anja Scheller | 2023 | Neural Regeneration Research2023，18，4： | 0 |
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